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Rockland
Fibrinogen Polyclonal Antibody
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FIGURE: 1 / 2
Fibrinogen Antibody (100-101-240) in IHC (P)
Immunohistochemistry of Goat Anti-Fibrinogen antibody. Tissue: human liver tissue. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: Fibrinogen antibody at 1:500 for 1 h at RT. Secondary antibody: Peroxidase goat secondary antibody at 1:10,000 for 45 min at RT. Localization: Fibrinogen is localized in plasma. Staining: Fibrinogen as precipitated red signal wit... View More
Product Details
100-101-240
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fibrinogen [Human Plasma]
Conjugate
Form
Lyophilized
Concentration
90 mg/mL
Storage buffer
0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-goat serum, purified and partially purified Fibrinogen [Human Plasma]. Cross reactivity against Fibrinogen from other sources is unknown.
Target Information
Fibrinogen, the precursor of fibrin, is the coagulable protein in the blood plasma of vertebrates. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Fibrinogen consists as a dimer of 3 pairs of non-identical chains FGA, FGB, and FGG that are cross-linked by disulfide bonds in their N-terminal segments. The molecule has 2 terminal D domains and one central E domain, all three domains are separated when fibrinogen is degradated by plasmin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, afibrinogenemia, and renal amyloidosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein Li 78p; fibg; Fibrinogen alpha chain; Fibrinogen beta chain; Fibrinogen gamma chain; fibrinogen, A alpha polypeptide; fibrinogen, B beta polypeptide; fibrinogen, gamma polypeptide; MGC119422; MGC119423; MGC119425; testicular tissue protein Li 70
Gene Aliases: FGA; FGB; FGG; Fib2; HEL-S-78p; PRO2061
UniProt ID: (Human) P02671, (Human) P02675, (Human) P02679
Entrez Gene ID: (Human) 2243, (Human) 2244, (Human) 2266
platelet degranulation
cell-matrix adhesion
signal transduction
blood coagulation
protein secretion
extracellular matrix organization
plasminogen activation
positive regulation of heterotypic cell-cell adhesion
fibrinolysis
cellular protein complex assembly
positive regulation of vasoconstriction
positive regulation of exocytosis
positive regulation of protein secretion
protein polymerization
response to calcium ion
positive regulation of ERK1 and ERK2 cascade
platelet aggregation
blood coagulation, fibrin clot formation
positive regulation of peptide hormone secretion
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of endothelial cell apoptotic process
adaptive immune response
induction of bacterial agglutination
cellular response to leptin stimulus
innate immune response
cellular response to interleukin-1
protein complex assembly
acute-phase response
response to estradiol
response to genistein
response to morphine
cellular protein metabolic process
response to cycloheximide
cellular response to interleukin-6
cellular response to organic cyclic compound
blood coagulation, common pathway
liver regeneration
cellular response to granulocyte colony-stimulating factor
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