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Invitrogen
Fibrinogen gamma Recombinant Rabbit Monoclonal Antibody (HL1395)
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FIGURE: 1 / 5
Fibrinogen gamma Antibody (MA5-47028) in ICC/IF
Immunofluorescent analysis of Fibrinogen gamma in HepG2 cells. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Fibrinogen gamma stained by Fibrinogen gamma monoclonal antibody (Product # MA5-47028) diluted at 1:50. Blue: Fluoroshield with DAPI. Scale bar= 10 µm.
Product Details
MA5-47028
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL1395
Immunogen
Recombinant protein encompassing a sequence within the center region of human Fibrinogen gamma. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2938100
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fibg; Fibrinogen gamma chain; fibrinogen gamma-chain; fibrinogen, gamma polypeptide; gamma-fibrinogen; testicular tissue protein Li 70
Gene Aliases: 3010002H13Rik; AI256424; FGG; PRO2061
UniProt ID: (Human) P02679, (Mouse) Q8VCM7, (Rat) P02680
Entrez Gene ID: (Human) 2266, (Mouse) 99571, (Rat) 24367
platelet degranulation
cell-matrix adhesion
signal transduction
blood coagulation
protein secretion
extracellular matrix organization
plasminogen activation
positive regulation of heterotypic cell-cell adhesion
fibrinolysis
cellular protein complex assembly
positive regulation of vasoconstriction
positive regulation of exocytosis
positive regulation of protein secretion
protein polymerization
response to calcium ion
positive regulation of ERK1 and ERK2 cascade
platelet aggregation
blood coagulation, fibrin clot formation
positive regulation of peptide hormone secretion
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of endothelial cell apoptotic process
immune system process
hemostasis
platelet activation
innate immune response
inflammatory response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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