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Fibrinogen gamma chain Polyclonal Antibody

Fibrinogen gamma chain Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Fibrinogen gamma chain Antibody (15841-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human hepatocirrhosis tissue slide using (Product # 15841-1-AP) (Fibrinogen gamma chain antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Fibrinogen gamma chain Antibody in Western Blot (WB)

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Product Details

15841-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Fibrinogen gamma chain Fusion Protein Ag8597 (90-437 aa encoded by BC007044)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: IQLTYNPDE SSKPNMIDAA TLKSRKMLEE IMKYEASILT HDSSIRYLQE IYNSNNQKIV NLKEKVAQLE AQCQEPCKDT VQIHDITGKD CQDIANKGAK QSGLYFIKPL KANQQFLVYC EIDGSGNGWT VFQKRLDGSV DFKKNWIQYK EGFGHLSPTG TTEFWLGNEK IHLISTQSAI PYALRVELED WNGRTSTADY AMFKVGPEAD KYRLTYAYFA GGDAGDAFDG FDFGDDPSDK FFTSHNGMQF STWDNDNDKF EGNCAEQDGS GWWMNKCHAG HLNGVYYQGG TYSKASTPNG YDNGIIWATW KTRWYSMKKT TMKIIPFNRL TIGEGQQHHL GGAKQAGDV (90-437 aa encoded by BC007044)

Target Information

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells.

Fluids and barriers of the CNS

Luo Y,Yao F,Shi Y,Zhu Z,Xiao Z,You X,Liu Y,Yu S,Tian D,Cheng L,Zheng M,Jing J

Mon Jan 09 00:00:00 UTC 2023

Myelin Debris Impairs Tight Junctions and Promotes the Migration of Microvascular Endothelial Cells in the Injured Spinal Cord.

Cellular and molecular neurobiology

Yao F,Luo Y,Chen Y,Li Y,Hu X,You X,Li Z,Yu S,Tian D,Zheng M,Cheng L,Jing J

Wed Mar 01 00:00:00 UTC 2023

M1 macrophages impair tight junctions between endothelial cells after spinal cord injury.

Brain research bulletin

Luo Y,Yao F,Hu X,Li Y,Chen Y,Li Z,Zhu Z,Yu S,Tian D,Cheng L,Zheng M,Jing J

Tue Mar 01 00:00:00 UTC 2022

Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury.

Inflammation and regeneration

Yao F,Luo Y,Liu YC,Chen YH,Li YT,Hu XY,You XY,Yu SS,Li ZY,Chen L,Tian DS,Zheng MG,Cheng L,Jing JH

Mon Sep 26 00:00:00 UTC 2022

Accelerated accumulation of fibrinogen peptide chains with Aβ deposition in Alzheimer's disease (AD) mice and human AD brains.

Brain research

Bian Z,Yamashita T,Shi X,Feng T,Yu H,Hu X,Hu X,Bian Y,Sun H,Tadokoro K,Takemoto M,Omote Y,Morihara R,Abe K

Wed Sep 15 00:00:00 UTC 2021

Integrated analysis reveals lung fibrinogen gamma chain as a biomarker for chronic obstructive pulmonary disease.

Annals of translational medicine

Zhang H,Li C,Song X,Cheng L,Liu Q,Zhang N,Wei L,Chung K,Adcock IM,Ling C,Li F

Wed Dec 01 00:00:00 UTC 2021

Integrated analysis reveals lung fibrinogen gamma chain as a biomarker for chronic obstructive pulmonary disease.

Annals of translational medicine

Zhang H,Li C,Song X,Cheng L,Liu Q,Zhang N,Wei L,Chung K,Adcock IM,Ling C,Li F

Wed Dec 01 00:00:00 UTC 2021

Tear dynamics testing and quantitative proteomics analysis in patients with chronic renal failure.

Journal of proteomics

Zong RR,Zhu FF,Han W,Wang YX,Wang GL,Wang YZ,Mao YB,Guan TJ,Liu ZG,Xue YH,Li C

Thu Sep 30 00:00:00 UTC 2021

C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1.

Scientific reports

Alberts A,Klingberg A,Wessig AK,Combes C,Witte T,Brand K,Pich A,Neumann K

Tue Apr 14 00:00:00 UTC 2020

FTY720 Attenuates Neuropathic Pain after Spinal Cord Injury by Decreasing Systemic and Local Inflammation in a Rat Spinal Cord Compression Model.

Journal of neurotrauma

Yamazaki K,Kawabori M,Seki T,Takamiya S,Tateno T,Konno K,Watanabe M,Houkin K

Sat Aug 01 00:00:00 UTC 2020

Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) crosslinking via tissue transglutaminase.

Journal of thrombosis and haemostasis : JTH

Poole LG,Pant A,Baker KS,Kopec AK,Cline-Fedewa HM,Iismaa SE,Flick MJ,Luyendyk JP

Tue Jan 01 00:00:00 UTC 2019

Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) crosslinking via tissue transglutaminase.

Journal of thrombosis and haemostasis : JTH

Poole LG,Pant A,Baker KS,Kopec AK,Cline-Fedewa HM,Iismaa SE,Flick MJ,Luyendyk JP

Tue Jan 01 00:00:00 UTC 2019

Quantitative iTRAQ-based proteomic analysis of piperine protected cerebral ischemia/reperfusion injury in rat brain.

Neurochemistry international

Zou Y,Gong P,Zhao W,Zhang J,Wu X,Xin C,Xiong Z,Li Z,Wu X,Wan Q,Li X,Chen J

Fri Mar 01 00:00:00 UTC 2019

Quantitative iTRAQ-based proteomic analysis of piperine protected cerebral ischemia/reperfusion injury in rat brain.

Neurochemistry international

Zou Y,Gong P,Zhao W,Zhang J,Wu X,Xin C,Xiong Z,Li Z,Wu X,Wan Q,Li X,Chen J

Fri Mar 01 00:00:00 UTC 2019

Fibrinogen Chains Intrinsic to the Brain.

Frontiers in neuroscience

Golanov EV,Sharpe MA,Regnier-Golanov AS,Del Zoppo GJ,Baskin DS,Britz GW

Thu Oct 01 00:00:00 UTC 2020

Fibrinogen Chains Intrinsic to the Brain.

Frontiers in neuroscience

Golanov EV,Sharpe MA,Regnier-Golanov AS,Del Zoppo GJ,Baskin DS,Britz GW

Thu Oct 01 00:00:00 UTC 2020

Fibrinogen Chains Intrinsic to the Brain.

Frontiers in neuroscience

Golanov EV,Sharpe MA,Regnier-Golanov AS,Del Zoppo GJ,Baskin DS,Britz GW

Thu Oct 01 00:00:00 UTC 2020

Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury.

Blood

Krishnamoorthy A,Ajay AK,Hoffmann D,Kim TM,Ramirez V,Campanholle G,Bobadilla NA,Waikar SS,Vaidya VS

Thu Aug 18 00:00:00 UTC 2011

Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury.

Blood

Krishnamoorthy A,Ajay AK,Hoffmann D,Kim TM,Ramirez V,Campanholle G,Bobadilla NA,Waikar SS,Vaidya VS

Thu Aug 18 00:00:00 UTC 2011

Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury.

Blood

Krishnamoorthy A,Ajay AK,Hoffmann D,Kim TM,Ramirez V,Campanholle G,Bobadilla NA,Waikar SS,Vaidya VS

Thu Aug 18 00:00:00 UTC 2011

Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury.

Blood

Krishnamoorthy A,Ajay AK,Hoffmann D,Kim TM,Ramirez V,Campanholle G,Bobadilla NA,Waikar SS,Vaidya VS

Thu Aug 18 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: fibg; Fibrinogen gamma chain; fibrinogen gamma-chain; fibrinogen, gamma polypeptide; gamma-fibrinogen; testicular tissue protein Li 70

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Gene Aliases: 3010002H13Rik; AI256424; FGG; PRO2061

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UniProt ID: (Human) P02679, (Mouse) Q8VCM7, (Rat) P02680

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Entrez Gene ID: (Human) 2266, (Mouse) 99571, (Rat) 24367

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Function(s)

receptor binding structural molecule activity protein binding protein binding, bridging metal ion binding cell adhesion molecule binding molecular_function

Process(es)

platelet degranulation cell-matrix adhesion signal transduction blood coagulation protein secretion extracellular matrix organization plasminogen activation positive regulation of heterotypic cell-cell adhesion fibrinolysis cellular protein complex assembly positive regulation of vasoconstriction positive regulation of exocytosis positive regulation of protein secretion protein polymerization response to calcium ion positive regulation of ERK1 and ERK2 cascade platelet aggregation blood coagulation, fibrin clot formation positive regulation of peptide hormone secretion positive regulation of substrate adhesion-dependent cell spreading negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of endothelial cell apoptotic process immune system process hemostasis platelet activation innate immune response inflammatory response

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Fibrinogen gamma chain Polyclonal Antibody

Fibrinogen gamma chain Antibody (15841-1-AP) in IHC (P)

Product Details

15841-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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