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Proteintech
Fibrinogen gamma chain Monoclonal Antibody (2B2B8)
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Product Details
66158-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
2B2B8
Immunogen
Fibrinogen gamma chain Fusion Protein Ag8817 (90-437 aa encoded by BC007044)
Conjugate
Form
Liquid
Concentration
1.2 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IQLTYNPDE SSKPNMIDAA TLKSRKMLEE IMKYEASILT HDSSIRYLQE IYNSNNQKIV NLKEKVAQLE AQCQEPCKDT VQIHDITGKD CQDIANKGAK QSGLYFIKPL KANQQFLVYC EIDGSGNGWT VFQKRLDGSV DFKKNWIQYK EGFGHLSPTG TTEFWLGNEK IHLISTQSAI PYALRVELED WNGRTSTADY AMFKVGPEAD KYRLTYAYFA GGDAGDAFDG FDFGDDPSDK FFTSHNGMQF STWDNDNDKF EGNCAEQDGS GWWMNKCHAG HLNGVYYQGG TYSKASTPNG YDNGIIWATW KTRWYSMKKT TMKIIPFNRL TIGEGQQHHL GGAKQAGDV (90-437 aa encoded by BC007044)
Target Information
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: fibg; Fibrinogen gamma chain; fibrinogen, gamma polypeptide; testicular tissue protein Li 70
Gene Aliases: FGG; PRO2061
UniProt ID: (Human) P02679
Entrez Gene ID: (Human) 2266
platelet degranulation
cell-matrix adhesion
signal transduction
blood coagulation
protein secretion
extracellular matrix organization
plasminogen activation
positive regulation of heterotypic cell-cell adhesion
fibrinolysis
cellular protein complex assembly
positive regulation of vasoconstriction
positive regulation of exocytosis
positive regulation of protein secretion
protein polymerization
response to calcium ion
positive regulation of ERK1 and ERK2 cascade
platelet aggregation
blood coagulation, fibrin clot formation
positive regulation of peptide hormone secretion
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of endothelial cell apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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