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Invitrogen
Folate Receptor alpha Recombinant Rabbit Monoclonal Antibody (6A8A10)
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FIGURE: 1 / 5
Folate Receptor alpha Antibody (MA5-51425) in ICC/IF
Immunocytochemistry (confocal imaging) analysis of Folate Receptor alpha in HeLa cells. Samples were incubated with Folate Receptor alpha Recombinant monoclonal antibody (Product # MA5-51425) using a dilution of 1:100 (Red). The cells were counterstained with Vimentin Rabbit mAb (Product # MA5-35320, dilution 1:100) (Green). DAPI was used for nuclear staining (blue). Objective: 60x.
Product Details
MA5-51425
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6A8A10
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Folate Binding Protein(FBP) / FOLR1 (NP_000793.1).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3093747
Product Specific Information
Immunogen sequence: MAQRMTTQLL LLLVWVAVVG EAQTRIAWAR TELLNVCMNA KHHKEKPGPE DKLHEQCRPW RKNACCSTNT SQEAHKDVSY LYRFNWNHCG EMAPACKRHF
Target Information
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adult folate-binding protein; FBP; folate binding protein; folate binding protein 1; Folate receptor 1; folate receptor 1 (adult); Folate receptor alpha; Folate receptor, adult; Folate-binding protein 1; FR-alpha; KB cells FBP; MOv18; Ovarian tumor-associated antigen MOv18
Gene Aliases: FBP; FBP1; Folbp-1; Folbp1; FOLR; FOLR1
UniProt ID: (Human) P15328, (Mouse) P35846
Entrez Gene ID: (Human) 2348, (Rat) 171049, (Mouse) 14275
folic acid transport
folic acid metabolic process
posttranslational protein targeting to membrane
transport
heart looping
neural crest cell migration involved in heart formation
cardiac neural crest cell migration involved in outflow tract morphogenesis
ER to Golgi vesicle-mediated transport
receptor-mediated endocytosis
regulation of transforming growth factor beta receptor signaling pathway
axon regeneration
COPII vesicle coating
regulation of canonical Wnt signaling pathway
pharyngeal arch artery morphogenesis
anterior neural tube closure
cellular response to folic acid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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