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Invitrogen
FosB Polyclonal Antibody
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FIGURE: 1 / 7
FosB Antibody (PA5-79280) in IHC (P)
Immunohistochemical analysis of FOSB in paraffin-embedded section of human renal cancer tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution).The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1μg/mL rabbit anti-FOSB antibody (Product # PA5-79280) overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as se... View More
Product Details
PA5-79280
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Fos B (264-291aa LPFQTSQDAPPNLTASLFTHSEVQVLGD).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746396
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat thymus tissue, mouse thymus tissue, mouse ovary tissue, mouse spleen tissue, mouse kidney tissue, mouse RAW2467 whole cell, human HL-60 whole cell, human THP-1 whole cell. IHC: human renal cancer tissue, human placenta tissue, mouse intestine tissue, rat intestine tissue. Flow: SiHa cell.
Target Information
c-FOS is a nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. It has a critical function in regulating the development of cells destined to form and maintain the skeleton, and is thought to have an important role in signal transduction, cell proliferation and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activator protein 1; DKFZp686C0818; FBJ murine osteosarcoma viral oncogene homolog B; FBJ osteosarcoma oncogene B; FBJ osteosarcoma viral oncogene isoform deltaFosb-2; fos b; FosB proto-oncogene, AP-1 trancription factor subunit; FosB proto-oncogene, AP-1 transcription factor subunit; G0/G1 switch regulatory protein 3; MGC42291; oncogene FOS-B; Protein FosB; Transcription factor AP-1 subunit FosB
Gene Aliases: AP-1; FOSB; fra-2; G0S3; GOS3; GOSB
UniProt ID: (Human) P53539, (Rat) D3ZLB7, (Mouse) P13346
Entrez Gene ID: (Human) 2354, (Rat) 100360880, (Mouse) 14282
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor binding
RNA polymerase II regulatory region sequence-specific DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
protein heterodimerization activity
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
female pregnancy
response to mechanical stimulus
response to progesterone
cellular response to hormone stimulus
response to drug
response to morphine
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
response to corticosterone
response to cAMP
cellular response to calcium ion
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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