Proteintech

Frizzled 2 Polyclonal Antibody

Frizzled 2 Antibody in Western Blot (WB)

FIGURE: 1 / 4

Frizzled 2 Antibody (24272-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 24272-1-AP) (Frizzled 2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Product Details

24272-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Frizzled 2 Fusion Protein Ag18003 (138-217 aa encoded by BC113402)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: CEHFPRHGA EQICVGQNHS EDGAPALLTT APPPGLQPGA GGTPGGPGGG GAPPRYATLE HPFHCPRVLK VPSYLSYKFL G (138-217 aa encoded by BC113402)

Target Information

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling.

Acta pharmacologica Sinica

Wu H,Tang LX,Wang XM,Li LP,Chen XK,He YJ,Yang DZ,Shi Y,Shou JL,Zhang ZS,Wang L,Lu BJ,An SM,Zeng CY,Wang WE

Thu Jun 01 00:00:00 UTC 2023

Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/β-Catenin Signaling Pathway in Psoriasis Mouse Model.

Evidence-based complementary and alternative medicine : eCAM

Yang X,Luo G,Fu L,Huang H,Wang L,Yin L,Zhang X,Wang T,Ma X,Feng T,Ye J

Sat Jul 16 00:00:00 UTC 2022

Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer.

Cell death discovery

Xu H,Xia H,Zhou S,Tang Q,Bi F

Fri Feb 26 00:00:00 UTC 2021

Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway.

Genes & diseases

Liu Y,Deng H,Liang L,Zhang G,Xia J,Ding K,Tang N,Wang K

Mon Mar 01 00:00:00 UTC 2021

Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl₄/2-AAF.

Pharmaceutical biology

Xu Y,Xu W,Liu W,Chen G,Jiang S,Chen J,Jian X,Zhang H,Liu P,Mu Y

Wed Dec 01 00:00:00 UTC 2021

Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3β Complex in Hypophosphatasia.

Theranostics

Liu W,Zhang L,Xuan K,Hu C,Li L,Zhang Y,Jin F,Jin Y

Mon Sep 09 00:00:00 UTC 2019

Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3β Complex in Hypophosphatasia.

Theranostics

Liu W,Zhang L,Xuan K,Hu C,Li L,Zhang Y,Jin F,Jin Y

Mon Sep 09 00:00:00 UTC 2019

Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B.

Frontiers in microbiology

Schöttelndreier D,Seeger K,Grassl GA,Winny MR,Lindner R,Genth H

Thu Oct 01 00:00:00 UTC 2020

Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B.

Frontiers in microbiology

Schöttelndreier D,Seeger K,Grassl GA,Winny MR,Lindner R,Genth H

Thu Oct 01 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: Dfrizzled2; Drosophila polarity gene (frizzled) homologue; Drosophila polarity gene homolog 2; frizzled 2, seven transmembrane spanning receptor; frizzled family receptor 2; frizzled homolog 2; Frizzled-10; Frizzled-2; Fz-10; Fz-2; FzE2; mFz2; rFz2

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Gene Aliases: AL033370; AW456835; Fz-10; fz-2; Fz10; Fz2; Fzd10; FZD2; fzE2; hFz2; Mfz10; Mfz10a

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UniProt ID: (Human) Q14332, (Rat) Q08464, (Mouse) Q9JIP6

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Entrez Gene ID: (Human) 2535, (Rat) 64512, (Mouse) 57265

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Function(s)

G-protein coupled receptor activity protein binding Wnt-protein binding PDZ domain binding Wnt-activated receptor activity identical protein binding protein heterodimerization activity signal transducer activity transmembrane signaling receptor activity

Process(es)

membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis G-protein coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway sensory perception of smell neuron differentiation positive regulation of cGMP metabolic process epithelial cell differentiation non-canonical Wnt signaling pathway positive regulation of transcription, DNA-templated positive regulation of sequence-specific DNA binding transcription factor activity hard palate development canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway inner ear receptor cell development cochlea morphogenesis planar cell polarity pathway involved in neural tube closure beta-catenin destruction complex disassembly cell activation signal transduction G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger positive regulation of cytosolic calcium ion concentration cell-cell signaling multicellular organism development ventricular septum morphogenesis cellular response to vitamin D cellular response to growth factor stimulus cellular response to peptide hormone stimulus cell surface receptor signaling pathway Wnt signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Frizzled 2 Polyclonal Antibody

Frizzled 2 Antibody (24272-1-AP) in WB

Product Details

24272-1-AP

Western Blot (WB)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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