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Invitrogen
Frizzled-2 Polyclonal Antibody
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FIGURE: 1 / 4
Frizzled-2 Antibody (PA5-18884) in ICC/IF
Immunocytochemistry analysis of Frizzled-2 using Frizzled-2 Polyclonal Antibody (Product # PA5-18884) in paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing nuclear and cytoplasmic staining. Actin filaments were stained with phalloidin (red). Negative control: Unimmunized goat IgG (10 µg/mL) f... View More
Product Details
PA5-18884
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (RYATLEHPFHCPR) corresponding to the internal amino acids of FZD2 (aa 191-204).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10982648
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dfrizzled2; frizzled 2, seven transmembrane spanning receptor; frizzled family receptor 2; frizzled homolog 2; Frizzled-2; Fz-2; FzE2
Gene Aliases: fz-2; Fz2; FZD2; fzE2; hFz2
UniProt ID: (Human) Q14332
Entrez Gene ID: (Human) 2535
membranous septum morphogenesis
muscular septum morphogenesis
outflow tract morphogenesis
G-protein coupled receptor signaling pathway
Wnt signaling pathway, calcium modulating pathway
sensory perception of smell
neuron differentiation
positive regulation of cGMP metabolic process
epithelial cell differentiation
non-canonical Wnt signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
hard palate development
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
inner ear receptor cell development
cochlea morphogenesis
planar cell polarity pathway involved in neural tube closure
beta-catenin destruction complex disassembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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