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Invitrogen
Frizzled-2 Polyclonal Antibody
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Product Details
PA5-47119
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Frizzled-2 Gln29-Leu168
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2577150
Product Specific Information
In direct ELISAs, approximately 30% cross-reactivity with recombinant mouse (rm) Frizzled-1 is observed and less than 5% cross-reactivity with rmFrizzled-4, recombinant human Frizzled-5, rmFrizzled-6, and rmFrizzled-8 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.50 EU per 1 µg of the antibody by the LAL method.
Target Information
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dfrizzled2; Frizzled-10; Frizzled-2; Fz-10; Fz-2; mFz2
Gene Aliases: AL033370; AW456835; Fz10; Fzd10; Fzd2; Mfz10; Mfz10a
UniProt ID: (Mouse) Q9JIP6
Entrez Gene ID: (Mouse) 57265
membranous septum morphogenesis
muscular septum morphogenesis
outflow tract morphogenesis
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
Wnt signaling pathway, calcium modulating pathway
cell-cell signaling
multicellular organism development
sensory perception of smell
Wnt signaling pathway
positive regulation of cGMP metabolic process
epithelial cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
hard palate development
canonical Wnt signaling pathway
inner ear receptor cell development
ventricular septum morphogenesis
cochlea morphogenesis
planar cell polarity pathway involved in neural tube closure
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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