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Bioss
Frizzled 4/CD344 Polyclonal Antibody
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Product Details
BS-13217R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Frizzled 4/CD344, amino acids 151-250.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
FZD4 is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. Frizzled 4 is widely expressed, particularly in heart, skeletal muscle, ovary, and fetal kidney. Transcripts have also been identified in liver, kidney, pancreas, spleen, and fetal lung, and in smaller amounts in placenta, adult lung, prostate, testis, colon, and fetal brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD344; CD344 antigen; frizzled 4, seven transmembrane spanning receptor; frizzled family receptor 4; frizzled homolog 4; frizzled receptor 4; Frizzled-4; Fz-4; FzE4; mFz4; MGC34390; rFz4; WNT receptor frizzled-4
Gene Aliases: CD344; EVR1; FEVR; Fz-4; Fz4; FZD4; FZD4S; FzE4; GPCR; hFz4
UniProt ID: (Human) Q9ULV1, (Mouse) Q61088, (Rat) Q9QZH0
Entrez Gene ID: (Human) 8322, (Mouse) 14366, (Rat) 64558
G-protein coupled receptor activity
protein binding
Wnt-protein binding
cytokine binding
PDZ domain binding
ubiquitin protein ligase binding
protein homodimerization activity
Wnt-activated receptor activity
protein heterodimerization activity
signal transducer activity
transmembrane signaling receptor activity
luteinization
blood vessel development
vasculogenesis
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
Wnt signaling pathway, calcium modulating pathway
multicellular organism development
sensory perception of sound
negative regulation of cell-substrate adhesion
Wnt signaling pathway
regulation of vascular endothelial growth factor receptor signaling pathway
locomotion involved in locomotory behavior
substrate adhesion-dependent cell spreading
extracellular matrix-cell signaling
non-canonical Wnt signaling pathway
progesterone secretion
positive regulation of JUN kinase activity
positive regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
canonical Wnt signaling pathway
retina vasculature morphogenesis in camera-type eye
cerebellum vasculature morphogenesis
retinal blood vessel morphogenesis
neuron differentiation
Wnt signaling pathway, planar cell polarity pathway
cellular response to retinoic acid
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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