Bioss

Frizzled 5/8 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

BS-2930R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Frizzled 5.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The Frizzled 5 protein is believed to be the receptor for the Wnt5A ligand. Frizzled 5 has been reported to be expressed in fetal kidney, fetal and adult liver, fetal lung, and adult pancreas. ESTs have been isolated from bone, liver/spleen, placenta, and prostate libraries. Frizzled 5 was cloned from a retina cDNA library. Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: frizzled 5, seven transmembrane spanning receptor; frizzled 8, seven transmembrane spanning receptor; frizzled family receptor 5; frizzled family receptor 8; frizzled homolog 8; Frizzled-5; Frizzled-8; Fz-5; Fz-8; FzE5; seven-transmembrane receptor frizzled-5; Wnt receptor

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Gene Aliases: 5330434N09Rik; AI427138; C2orf31; Fz-5; FZ-8; Fz5; Fz8; FZD5; FZD8; HFZ5; hFZ8; mFz5

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UniProt ID: (Human) Q13467, (Human) Q9H461, (Mouse) Q9EQD0, (Rat) Q8CHL0, (Mouse) Q61091, (Rat) Q498S8

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Entrez Gene ID: (Human) 7855, (Human) 8325, (Mouse) 14367, (Rat) 317674, (Mouse) 14370, (Rat) 364754

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Function(s)
beta-amyloid binding G-protein coupled receptor activity protein binding Wnt-protein binding protein kinase binding ubiquitin protein ligase binding Wnt-activated receptor activity receptor binding PDZ domain binding signal transducer activity transmembrane signaling receptor activity molecular_function
Process(es)
embryonic axis specification angiogenesis positive regulation of T cell cytokine production G-protein coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway synapse assembly negative regulation of cell proliferation anterior/posterior axis specification, embryo neuron differentiation post-embryonic camera-type eye development positive regulation of interferon-gamma production T cell differentiation in thymus non-canonical Wnt signaling pathway positive regulation of JUN kinase activity Wnt signaling pathway involved in dorsal/ventral axis specification positive regulation of transcription from RNA polymerase II promoter cell maturation embryonic camera-type eye morphogenesis Spemann organizer formation canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway apoptotic process involved in morphogenesis branching involved in labyrinthine layer morphogenesis syncytiotrophoblast cell differentiation involved in labyrinthine layer development labyrinthine layer blood vessel development chorionic trophoblast cell differentiation regulation of canonical Wnt signaling pathway cellular response to molecule of bacterial origin regulation of chorionic trophoblast cell proliferation regulation of mitophagy positive regulation of protein targeting to mitochondrion beta-catenin destruction complex disassembly regulation of bicellular tight junction assembly vasculature development signal transduction cell surface receptor signaling pathway multicellular organism development Wnt signaling pathway cell differentiation embryonic camera-type eye development negative regulation of transcription from RNA polymerase II promoter positive regulation of protein phosphorylation biological_process
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