Proteintech

G0S2 Polyclonal Antibody

G0S2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 2

G0S2 Antibody (12091-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver tissue slide using 12091-1-AP (G0S2 antibody) at dilution of 1:100 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Product Image Gallery

Product Details

12091-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

ChIP assay (ChIP)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

G0S2 Fusion Protein Ag2731 (1-103 aa encoded by BC009694)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: METVQELIP LAKEMMAQKR KGKMVKLYVL GSVLALFGVV LGLMETVCSP FTAARRLRDQ EAAVAELQAA LERQALQKQA LQEKGKQQDT VLGGRALSNR QHAS (1-103 aa encoded by BC009694)

Target Information

The G(0)-G(1) switch gene 2 (G0S2) codes for a mitochondrial protein that is important in apoptosis, lipolysis, and triacylglycerol hydrolysis. In adipocytes, G0S2 binds to adipose triglyceride lipase and decreases the breakdown of lipid droplets. In Crohn's colitis, the presence of G0S2 is increased in correlation to the amount of non-converted lipid in waste. In squamous lung cancer, mutations in the G0S2 gene are common. In breast cancer, epigenetic silencing of G0S2 occurs, and normal apoptotic regulation of aberrant cells is negatively impacted. However, when G0S2 is not epigenetically modified, it is the best mediator of the Bcl-2/Bax heterodimer, resulting in apoptosis of cancerous cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1α-dependent fat catabolism in immortalized human bronchial epithelial cells.

Toxicology mechanisms and methods

Ye F,Zeng Q,Dan G,Zhao Y,Yu W,Cheng J,Chen M,Wang B,Zhao J,Sai Y,Zou Z

Mon May 01 00:00:00 UTC 2023

G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells.

Translational oncology

Corbet AK,Bikorimana E,Boyd RI,Shokry D,Kries K,Gupta A,Paton A,Sun Z,Fazal Z,Freemantle SJ,Nelson ER,Spinella MJ,Singh R

Sat Jul 01 00:00:00 UTC 2023

Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer.

Cancer research

Sela Y,Li J,Maheswaran S,Norgard R,Yuan S,Hubbi M,Doepner M,Xu JP,Ho ES,Mesaros C,Sheehan C,Croley G,Muir A,Blair IA,Shalem O,Dang CV,Stanger BZ

Mon May 16 00:00:00 UTC 2022

Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages.

Cell death & disease

Ai K,Pan J,Zhang P,Li H,He Z,Zhang H,Li X,Li Y,Yi L,Kang Y,Wang Y,Xiang X,Chai X,Zhang D

Tue Feb 08 00:00:00 UTC 2022

Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages.

Cell death & disease

Ai K,Pan J,Zhang P,Li H,He Z,Zhang H,Li X,Li Y,Yi L,Kang Y,Wang Y,Xiang X,Chai X,Zhang D

Tue Feb 08 00:00:00 UTC 2022

MIN score predicts primary response to infliximab/adalimumab and vedolizumab therapy in patients with inflammatory bowel diseases.

Genomics

Shi Y,He W,Zhong M,Yu M

Thu Jul 01 00:00:00 UTC 2021

Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults.

The Journal of clinical endocrinology and metabolism

Ryan BJ,Schleh MW,Ahn C,Ludzki AC,Gillen JB,Varshney P,Van Pelt DW,Pitchford LM,Chenevert TL,Gioscia-Ryan RA,Howton SM,Rode T,Hummel SL,Burant CF,Little JP,Horowitz JF

Sat Aug 01 00:00:00 UTC 2020

Regulation of lipid metabolism in pancreatic beta cells by interferon gamma: A link to anti-viral function.

Cytokine

Truong NTT,Lydic TA,Bazil JN,Suryadevara A,Olson LK

Tue Sep 01 00:00:00 UTC 2020

Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds.

Nature communications

Guerrero-Juarez CF,Dedhia PH,Jin S,Ruiz-Vega R,Ma D,Liu Y,Yamaga K,Shestova O,Gay DL,Yang Z,Kessenbrock K,Nie Q,Pear WS,Cotsarelis G,Plikus MV

Fri Feb 08 00:00:00 UTC 2019

Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues.

Cell reports

Raajendiran A,Ooi G,Bayliss J,O'Brien PE,Schittenhelm RB,Clark AK,Taylor RA,Rodeheffer MS,Burton PR,Watt MJ

Tue Apr 30 00:00:00 UTC 2019

Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response.

Journal of experimental & clinical cancer research : CR

Wang Y,Hou Y,Zhang W,Alvarez AA,Bai Y,Hu B,Cheng SY,Yang K,Li Y,Feng H

Fri Apr 05 00:00:00 UTC 2019

G0/G1 Switch Gene 2 controls adipose triglyceride lipase activity and lipid metabolism in skeletal muscle.

Molecular metabolism

Laurens C,Badin PM,Louche K,Mairal A,Tavernier G,Marette A,Tremblay A,Weisnagel SJ,Joanisse DR,Langin D,Bourlier V,Moro C

Fri Jul 01 00:00:00 UTC 2016

G0/G1 Switch Gene 2 controls adipose triglyceride lipase activity and lipid metabolism in skeletal muscle.

Molecular metabolism

Laurens C,Badin PM,Louche K,Mairal A,Tavernier G,Marette A,Tremblay A,Weisnagel SJ,Joanisse DR,Langin D,Bourlier V,Moro C

Fri Jul 01 00:00:00 UTC 2016

Endurance exercise training up-regulates lipolytic proteins and reduces triglyceride content in skeletal muscle of obese subjects.

The Journal of clinical endocrinology and metabolism

Louche K,Badin PM,Montastier E,Laurens C,Bourlier V,de Glisezinski I,Thalamas C,Viguerie N,Langin D,Moro C

Sun Dec 01 00:00:00 UTC 2013

Endurance exercise training up-regulates lipolytic proteins and reduces triglyceride content in skeletal muscle of obese subjects.

The Journal of clinical endocrinology and metabolism

Louche K,Badin PM,Montastier E,Laurens C,Bourlier V,de Glisezinski I,Thalamas C,Viguerie N,Langin D,Moro C

Sun Dec 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: G0/G1 switch protein 2; G0/G1 switch regulatory protein 2; G0/G1switch 2; G0S2-like protein; Putative lymphocyte G0/G1 switch gene; putative lymphocyte G0/G1 switch protein 2; RP1-28O10.2

View more View less

Gene Aliases: AI255151; AV006465; G0S2

View more View less

UniProt ID: (Human) P27469, (Mouse) Q61585

View more View less

Entrez Gene ID: (Human) 50486, (Mouse) 14373

View more View less

Function(s)

molecular_function protein binding

Process(es)

extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway apoptotic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

G0S2 Polyclonal Antibody

G0S2 Antibody (12091-1-AP) in IHC (P)

Product Details

12091-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!