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Bioss
G1switch 2 Polyclonal Antibody
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FIGURE: 1 / 1
G1switch 2 Antibody (BS-8656R) in ICC/IF
Tissue/cell: U-87 mg cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Antibody incubation with G1switch 2 Polyclonal Antibody, Unconjugated (bs-8656R) at 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody (bs-0295G-FITC) at 37°C for 90 minutes, DAPI (5 µg/mL, blue) was used to stain the cell n... View More
Product Details
BS-8656R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Sheep,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human G0/G1 switch protein 2, amino acids 6-90.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The G(0)-G(1) switch gene 2 (G0S2) codes for a mitochondrial protein that is important in apoptosis, lipolysis, and triacylglycerol hydrolysis. In adipocytes, G0S2 binds to adipose triglyceride lipase and decreases the breakdown of lipid droplets. In Crohn's colitis, the presence of G0S2 is increased in correlation to the amount of non-converted lipid in waste. In squamous lung cancer, mutations in the G0S2 gene are common. In breast cancer, epigenetic silencing of G0S2 occurs, and normal apoptotic regulation of aberrant cells is negatively impacted. However, when G0S2 is not epigenetically modified, it is the best mediator of the Bcl-2/Bax heterodimer, resulting in apoptosis of cancerous cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G0/G1 switch gene 2; G0/G1 switch protein 2; G0/G1 switch regulatory protein 2; G0/G1switch 2; G0S2-like protein; putative lymphocyte G0/G1 switch; Putative lymphocyte G0/G1 switch gene; putative lymphocyte G0/G1 switch protein 2; RP1-28O10.2
Gene Aliases: AI255151; AV006465; G0S2
UniProt ID: (Human) P27469, (Rat) Q5M840, (Mouse) Q61585
Entrez Gene ID: (Human) 50486, (Sheep) 101121790, (Rat) 289388, (Mouse) 14373
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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