Invitrogen

G3BP2 Polyclonal Antibody

G3BP2 Antibody in Immunohistochemistry (IHC)

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G3BP2 Antibody (PA5-53797) in IHC

Immunohistochemical staining of G3BP2 in human cerebellum, cerebral cortex, skin and testis using G3BP2 Polyclonal Antibody (Product # PA5-53797) (A) shows similar protein distribution across tissues to an independent G3BP2 Polyclonal Antibody (B).

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G3BP2 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of G3BP2 demonstrates antibody specificity. Immunohistochemical analysis of G3BP2 using anti-G3BP2 Polyclonal Antibody (Product # PA5-53797), shows significant staining of G3BP2 in human cerebral cortex and shows minimal or weak staining in human skin tissues. The relative expression levels of G3BP2 within each tissue is shown using RNA-Seq. {RE}

Product Details

PA5-53797

Applications

Tested Dilution

Publications

Western Blot (WB)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human G3BP2. Recombinant protein control fragment (Product #RP-91850).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2641802

Product Specific Information

Immunogen sequence: KNLEELEEKS TTPPPAEPVS LPQEPPKPRV EAKPEVQSQP PRVREQRPRE RPGFPPRGPR PGRGDMEQND S

Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 92%.

Target Information

G3BP2 gene ontology annotations related to this gene include stress granule assembly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Circular RNA Cwc27 contributes to Alzheimer's disease pathogenesis by repressing Pur-α activity.

Cell death and differentiation

Song C,Zhang Y,Huang W,Shi J,Huang Q,Jiang M,Qiu Y,Wang T,Chen H,Wang H

PA5-53797 was used in Immunoprecipitation to suggest significant functional consequences of a circRNA-protein interaction, that circCwc27, by associating with the regulatory protein Pur-α, may act as a crucial player in AD pathogenesis and represent a promising AD therapeutic target with clinical translational potential.

Tue Feb 01 00:00:00 UTC 2022

Human Insulin Growth Factor 2 mRNA Binding Protein 2 Increases MicroRNA 33a/b Inhibition of Liver ABCA1 Expression and Alters Low-Density Apolipoprotein Levels in Mice.

Molecular and cellular biology

Yang M,Gallo-Ebert C,Hayward M,Liu W,McDonough V,Nickels JT

PA5-53797 was used in Western Blotting to support the hypothesis that IGF2BP2 has an important role in maintaining lipid homeostasis through its modulation of ABCA1 expression, as its overexpression or loss leads to dyslipidemia.

Wed Jul 29 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: G3BP-2; GAP SH3 domain-binding protein 2; GTPase activating protein (SH3 domain) binding protein 2; Ras GTPase-activating protein-binding protein 2; Ras-GTPase activating protein SH3 domain-binding protein 2

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Gene Aliases: G3BP2; KIAA0660

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UniProt ID: (Human) Q9UN86

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Entrez Gene ID: (Human) 9908

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Function(s)

nucleotide binding protein binding receptor signaling complex scaffold activity poly(A) RNA binding

Process(es)

cytoplasmic sequestering of NF-kappaB Ras protein signal transduction mRNA transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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G3BP2 Polyclonal Antibody

G3BP2 Antibody (PA5-53797) in IHC

Product Details

PA5-53797

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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