Proteintech

GABARAP Polyclonal Antibody

GABARAP Antibody in Immunocytochemistry (ICC/IF)

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GABARAP Antibody (18723-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed Chloroquine treated HepG2 cells and untreated HepG2 cells using GABARAP antibody (Product # 18723-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

18723-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 15 publications 15 publications

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Immunoprecipitation (IP)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody detected endogenous GABARAP protein in lysates from various tissues. It may cross-react with GABARAPL1 due to the high identity of amino acid sequence.

Target Information

Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Population-based genetic analysis in infertile men reveals novel mutations of ADAD family members in patients with impaired spermatogenesis.

Human molecular genetics

Dai S,Liu M,Liu M,Jiang C,Yang Y,Han H,Yang Y,Jiang X,Shen Y

Thu May 18 00:00:00 UTC 2023

β-asarone prolongs sleep via regulating the level of glutamate in the PVN.

Biochemical and biophysical research communications

Liu H,Zhou R,Yin L,Si N,Yang C,Huang C,Wang R,Chen X

Wed Jul 12 00:00:00 UTC 2023

Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.

Cell death and differentiation

Zhang G,Jiang C,Yang Y,Wang Y,Zhou H,Dai S,Liu M,Yang Y,Yang L,Shen Q,Zhang T,Zhang X,Yang Y,Shen Y

Wed Feb 01 00:00:00 UTC 2023

Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.

Cell death and differentiation

Zhang G,Jiang C,Yang Y,Wang Y,Zhou H,Dai S,Liu M,Yang Y,Yang L,Shen Q,Zhang T,Zhang X,Yang Y,Shen Y

Wed Feb 01 00:00:00 UTC 2023

Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.

Cell death and differentiation

Zhang G,Jiang C,Yang Y,Wang Y,Zhou H,Dai S,Liu M,Yang Y,Yang L,Shen Q,Zhang T,Zhang X,Yang Y,Shen Y

Wed Feb 01 00:00:00 UTC 2023

Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABA_A receptor transport in a murine model.

Experimental & molecular medicine

Liu J,Ke P,Guo H,Gu J,Liu Y,Tian X,Wang X,Xiao F

Thu Jun 01 00:00:00 UTC 2023

ATF3 -activated accelerating effect of LINC00941/lncIAPF on fibroblast-to-myofibroblast differentiation by blocking autophagy depending on ELAVL1/HuR in pulmonary fibrosis.

Autophagy

Zhang J,Wang H,Chen H,Li H,Xu P,Liu B,Zhang Q,Lv C,Song X

Tue Nov 01 00:00:00 UTC 2022

PEBP balances apoptosis and autophagy in whitefly upon arbovirus infection.

Nature communications

Wang S,Guo H,Zhu-Salzman K,Ge F,Sun Y

Fri Feb 11 00:00:00 UTC 2022

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.

Nature communications

Boland S,Swarup S,Ambaw YA,Malia PC,Richards RC,Fischer AW,Singh S,Aggarwal G,Spina S,Nana AL,Grinberg LT,Seeley WW,Surma MA,Klose C,Paulo JA,Nguyen AD,Harper JW,Walther TC,Farese RV

Fri Oct 07 00:00:00 UTC 2022

ATF4 links ER stress with reticulophagy in glioblastoma cells.

Autophagy

Zielke S,Kardo S,Zein L,Mari M,Covarrubias-Pinto A,Kinzler MN,Meyer N,Stolz A,Fulda S,Reggiori F,Kögel D,van Wijk S

Wed Sep 01 00:00:00 UTC 2021

The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation.

Molecular cell

Sun L,Wang W,Han C,Huang W,Sun Y,Fang K,Zeng Z,Yang Q,Pan Q,Chen T,Luo X,Chen Y

Thu Nov 04 00:00:00 UTC 2021

The GABARAP Co-Secretome Identified by APEX2-GABARAP Proximity Labelling of Extracellular Vesicles.

Cells

Sanwald JL,Poschmann G,Stühler K,Behrends C,Hoffmann S,Willbold D

Tue Jun 16 00:00:00 UTC 2020

Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components.

Cell communication and signaling : CCS

Lindner P,Christensen SB,Nissen P,Møller JV,Engedal N

Mon Jan 27 00:00:00 UTC 2020

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy.

Current biology : CB

Chen Q,Xiao Y,Chai P,Zheng P,Teng J,Chen J

Mon Mar 04 00:00:00 UTC 2019

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy.

Current biology : CB

Chen Q,Xiao Y,Chai P,Zheng P,Teng J,Chen J

Mon Mar 04 00:00:00 UTC 2019

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy.

Current biology : CB

Chen Q,Xiao Y,Chai P,Zheng P,Teng J,Chen J

Mon Mar 04 00:00:00 UTC 2019

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy.

Current biology : CB

Chen Q,Xiao Y,Chai P,Zheng P,Teng J,Chen J

Mon Mar 04 00:00:00 UTC 2019

Protrudin modulates seizure activity through GABA_A receptor regulation.

Cell death & disease

Lu X,Yang Y,Zhou R,Li Y,Yang Y,Wang X

Wed Nov 27 00:00:00 UTC 2019

ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.

Autophagy

Skytte Rasmussen M,Mouilleron S,Kumar Shrestha B,Wirth M,Lee R,Bowitz Larsen K,Abudu Princely Y,O'Reilly N,Sjøttem E,Tooze SA,Lamark T,Johansen T

Thu May 04 00:00:00 UTC 2017

ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.

Autophagy

Skytte Rasmussen M,Mouilleron S,Kumar Shrestha B,Wirth M,Lee R,Bowitz Larsen K,Abudu Princely Y,O'Reilly N,Sjøttem E,Tooze SA,Lamark T,Johansen T

Thu May 04 00:00:00 UTC 2017

The lncRNA HOTAIRM1 regulates the degradation of PML-RARA oncoprotein and myeloid cell differentiation by enhancing the autophagy pathway.

Cell death and differentiation

Chen ZH,Wang WT,Huang W,Fang K,Sun YM,Liu SR,Luo XQ,Chen YQ

Wed Feb 01 00:00:00 UTC 2017

The lncRNA HOTAIRM1 regulates the degradation of PML-RARA oncoprotein and myeloid cell differentiation by enhancing the autophagy pathway.

Cell death and differentiation

Chen ZH,Wang WT,Huang W,Fang K,Sun YM,Liu SR,Luo XQ,Chen YQ

Wed Feb 01 00:00:00 UTC 2017

Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization.

Scientific reports

Boeske A,Schwarten M,Ma P,Tusche M,Mötter J,Möller C,Neudecker P,Hoffmann S,Willbold D

Thu Jul 20 00:00:00 UTC 2017

Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization.

Scientific reports

Boeske A,Schwarten M,Ma P,Tusche M,Mötter J,Möller C,Neudecker P,Hoffmann S,Willbold D

Thu Jul 20 00:00:00 UTC 2017

The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors.

European journal of cell biology

Labonté D,Thies E,Kneussel M

Mon Mar 30 00:00:00 UTC 2015

The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors.

European journal of cell biology

Labonté D,Thies E,Kneussel M

Mon Mar 30 00:00:00 UTC 2015

Defective autophagy and mTORC1 signaling in myotubularin null mice.

Molecular and cellular biology

Fetalvero KM,Yu Y,Goetschkes M,Liang G,Valdez RA,Gould T,Triantafellow E,Bergling S,Loureiro J,Eash J,Lin V,Porter JA,Finan PM,Walsh K,Yang Y,Mao X,Murphy LO

Tue Jan 01 00:00:00 UTC 2013

Defective autophagy and mTORC1 signaling in myotubularin null mice.

Molecular and cellular biology

Fetalvero KM,Yu Y,Goetschkes M,Liang G,Valdez RA,Gould T,Triantafellow E,Bergling S,Loureiro J,Eash J,Lin V,Porter JA,Finan PM,Walsh K,Yang Y,Mao X,Murphy LO

Tue Jan 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: FLJ25768; GABA(A) receptor-associated protein; GABA-A receptor-associated protein; GABARAP a; Gamma-aminobutyric acid receptor-associated protein; gamma-aminobutyric acid reseptor associated protein; hypothetical protein; MGC120154; MGC120155; MM46

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Gene Aliases: ATG8A; FLC3B; GABARAP; GABARAP-a; HT004; MM46

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UniProt ID: (Human) O95166, (Mouse) B1AR49

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Entrez Gene ID: (Human) 11337, (Mouse) 56486

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Function(s)

protein binding microtubule binding beta-tubulin binding GABA receptor binding

Process(es)

autophagosome assembly microtubule cytoskeleton organization mitophagy transport autophagy apoptotic process extrinsic apoptotic signaling pathway via death domain receptors protein transport nucleophagy membrane fusion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GABARAP Polyclonal Antibody

GABARAP Antibody (18723-1-AP) in ICC/IF

Product Details

18723-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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