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GABARAP Antibody (AIP-016-200UL) in IHC (F)
Expression of GABARAP in rat cortex. Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-GABARAP Antibody (#AIP-016), (1:1000), followed by donkey Anti-rabbit-biotin and Streptavidin-Cy3. A. GABARAP immunoreactivity (red) appears in cortical neurons (arrows). B. Pre-incubation of the Antibody with GABARAP Blocking Peptide (#BLP-IP016), suppressed staining. Cell nuclei are sta... View More
Product Details
AIP-016-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KFVYKEEHPFEKRR, corresponding to amino acid residues 2-15 of rat GABARAP, Intracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.85 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ25768; GABA(A) receptor-associated protein; GABA-A receptor-associated protein; GABARAP a; gamma-aminobutyric acid receptor associated protein; Gamma-aminobutyric acid receptor-associated protein; gamma-aminobutyric acid reseptor associated protein; hypothetical protein; MGC120154; MGC120155; MM46
Gene Aliases: ATG8A; FLC3B; GABARAP; GABARAP-a; HT004; MM46
UniProt ID: (Human) O95166, (Rat) P60517, (Mouse) B1AR49
Entrez Gene ID: (Human) 11337, (Rat) 58974, (Mouse) 56486
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