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Invitrogen
GABARAP Polyclonal Antibody
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GABARAP Antibody (PA1-4146) in WB
Western blot was performed using Anti-Gamma-aminobutyric acid receptor-associated protein Polyclonal Antibody (Product # PA1-4146) and 13.9 kDa band corresponding to Gamma-aminobutyric acid receptor-associated protein was observed. Chloroquine is known to increase the expression of Gamma-aminobutyric acid receptor-associated protein. Membrane enriched cell extracts (30 µg lysate) of A549 (Lane 1) and A549 treated with chloroquine (50uM/ml for 20 hr) (Lane 2), NIH/3T3 (Lane 3) and NIH/3T3 treated with chloroquine (50uM/ml for 20 hr) (Lane 4... View More
Product Details
PA1-4146
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues T(42) R G A P R P P P S S P P(54) of the 105 kDa rat GABA R2 protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2108023
Product Specific Information
PA1-4146 detects GABA Receptor Associated Protein Subunit 2 in human and rat samples.
PA1-4146 has been successfully used Western blot procedures. By Western blot this antibody detects a ~105 kDa protein representing GABA Receptor Associated Protein Subunit 2 in brain lysate.
The PA1-4146 immunogen is a synthetic peptide corresponding to residues T(42) R G A P R P P P S S P P(54) of the 105 kDa rat GABA R2 protein.
Target Information
Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ25768; GABA(A) receptor-associated protein; GABARAP a; gamma-aminobutyric acid receptor associated protein; Gamma-aminobutyric acid receptor-associated protein; hypothetical protein; MGC120154; MGC120155; MM46
Gene Aliases: ATG8A; FLC3B; GABARAP; GABARAP-a; HT004; MM46
UniProt ID: (Human) O95166, (Rat) P60517
Entrez Gene ID: (Human) 11337, (Rat) 58974
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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