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Invitrogen
GABBR1 Polyclonal Antibody
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Product Details
PA5-17075
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to human GABA(B)R1
Conjugate
Form
Liquid
Concentration
48 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10977848
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a); DAAP-188P13.3; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GABA(B) receptor; GABA-B receptor 1; GABA-B receptor, R1 subunit; GABA-B-R1; Gaba-b-r1a; Gaba-b1; GABA-BR1; Gaba-br1a receptor; GABA-BR1b receptor; GABAB; GABABR1; Gababr1 receptor; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid (GABA-B) receptor, 1; Gamma-aminobutyric acid type B receptor subunit 1; gb1; GBR1; HGB1a; OTTHUMP00000109099; OTTHUMP00000214725; seven transmembrane helix receptor
Gene Aliases: bM573K1.1; GABAB1; GABABR1; GABBR1; GABBR1-3; GB1; GPRC3A
UniProt ID: (Human) Q9UBS5, (Mouse) Q9WV18, (Rat) Q9Z0U4
Entrez Gene ID: (Human) 2550, (Mouse) 54393, (Rat) 81657
osteoblast differentiation
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
gamma-aminobutyric acid signaling pathway
negative regulation of cell proliferation
positive regulation of glutamate secretion
negative regulation of gamma-aminobutyric acid secretion
negative regulation of epinephrine secretion
negative regulation of dopamine secretion
response to nicotine
response to ethanol
negative regulation of synaptic transmission
positive regulation of growth hormone secretion
signal transduction
G-protein coupled receptor signaling pathway
regulation of glutamate secretion
regulation of cAMP biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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