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Invitrogen
GABRA5 Polyclonal Antibody
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GABRA5 Antibody (PA5-31163) in IHC (P)
GABRA5 Polyclonal Antibody detects GABA A Receptor alpha 5 protein at cytoplasm by immunohistochemical analysis. Sample: Paraffin-embedded mouse cerebellum. GABA A Receptor alpha 5 stained by GABRA5 Polyclonal Antibody (Product # PA5-31163) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-31163
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human GABA A Receptor alpha 5. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2548637
Product Specific Information
Recommended positive controls: GABRA5-transfected 293T.
Predicted reactivity: Mouse (100%), Rat (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
GABRA5 is a part of GABA, a major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GABA(A) receptor; GABA(A) receptor subunit alpha-5; GABAA receptor alpha5 subunit; GABAAR subunit alpha-5; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5; Gamma-aminobutyric acid receptor subunit alpha-5; ligand-gated ion channel subunit
Gene Aliases: A230018I05Rik; GABRA5
UniProt ID: (Human) P31644, (Mouse) Q8BHJ7
Entrez Gene ID: (Human) 2558, (Mouse) 110886
behavioral fear response
positive regulation of defense response to virus by host
transport
ion transport
chloride transport
signal transduction
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
sensory perception of sound
associative learning
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
neuron development
inner ear receptor cell development
innervation
cochlea development
mitophagy in response to mitochondrial depolarization
brain development
ion transmembrane transport
xenophagy
chloride transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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