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Invitrogen
GABRA6 Polyclonal Antibody
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GABRA6 Antibody (PA5-142768) in IHC (P)
Immunohistochemistry analysis of GABRA6 in human brain, cortex. Samples were incubated with GABRA6 polyclonal antibody (Product # PA5-142768) using a dilution of 5 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-142768
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence ENALGKLEVEGN-C.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933414
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A Receptor (GABA-A R) Subtype. GABA-A Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABA-A Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABA-A R function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA subunit A receptor alpha 6; GABA(A) receptor subunit alpha-6; GABA(A) receptor, alpha 6; GABAAR alpha6; GABAAR subunit alpha-6; GABRA 6; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, alpha 6; Gamma-aminobutyric acid receptor subunit alpha-6
Gene Aliases: GABRA6
UniProt ID: (Human) Q16445
Entrez Gene ID: (Human) 2559
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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