Product References
Dexamethasone-stimulated glucocorticoid receptor signaling positively regulates the endoplasmic reticulum-associated degradation (ERAD) mechanism in hepatocellular carcinoma cells.
Steroids
Erzurumlu Y,Dogan HK,Cataklı D
Sat Jul 01 00:00:00 UTC 2023
Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response.
bioRxiv : the preprint server for biology
Chen Y,Quan S,Patil V,Kunjamma RB,Tokars HM,Leisten ED,Chan J,Wong Y,Popko B
Mon Jan 23 00:00:00 UTC 2023
Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases.
Science translational medicine
Kartha N,Gianopulos JE,Schrank Z,Cavender SM,Dobersch S,Kynnap BD,Wallace-Povirk A,Wladyka CL,Santana JF,Kim JC,Yu A,Bridgwater CM,Fuchs K,Dysinger S,Lampano AE,Notta F,Price DH,Hsieh AC,Hingorani SR,Kugel S
Wed May 03 00:00:00 UTC 2023
GADD34 activates p53 and may have utility as a marker of atherosclerosis.
Frontiers in medicine
Tomiyoshi G,Nakamura R,Shinmen N,Yoshida Y,Mine S,Machida T,Iwase K,Iwadate Y,Hiwasa T,Kuroda H
Sun May 28 00:00:00 UTC 2023
GADD34 activates p53 and may have utility as a marker of atherosclerosis.
Frontiers in medicine
Tomiyoshi G,Nakamura R,Shinmen N,Yoshida Y,Mine S,Machida T,Iwase K,Iwadate Y,Hiwasa T,Kuroda H
Sun May 28 00:00:00 UTC 2023
Triiodothyronine positively regulates endoplasmic reticulum-associated degradation (ERAD) and promotes androgenic signaling in androgen-dependent prostate cancer cells.
Cellular signalling
Erzurumlu Y,Muhammed MT
Fri Sep 01 00:00:00 UTC 2023
PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability.
Brain : a journal of neurology
Fevga C,Tesson C,Carreras Mascaro A,Courtin T,van Coller R,Sakka S,Ferraro F,Farhat N,Bardien S,Damak M,Carr J,Ferrien M,Boumeester V,Hundscheid J,Grillenzoni N,Kessissoglou IA,Kuipers DJS,Quadri M,Corvol JC,Mhiri C,Hassan BA,Breedveld GJ,Lesage S,Mandemakers W,Brice A,Bonifati V
Wed Apr 19 00:00:00 UTC 2023
Translation Rescue by Targeting Ppp1r15a through Its Upstream Open Reading Frame in Sepsis-Induced Acute Kidney Injury in a Murine Model.
Journal of the American Society of Nephrology : JASN
Kidwell A,Yadav SPS,Maier B,Zollman A,Ni K,Halim A,Janosevic D,Myslinski J,Syed F,Zeng L,Waffo AB,Banno K,Xuei X,Doud EH,Dagher PC,Hato T
Wed Feb 01 00:00:00 UTC 2023
Translation Rescue by Targeting Ppp1r15a through Its Upstream Open Reading Frame in Sepsis-Induced Acute Kidney Injury in a Murine Model.
Journal of the American Society of Nephrology : JASN
Kidwell A,Yadav SPS,Maier B,Zollman A,Ni K,Halim A,Janosevic D,Myslinski J,Syed F,Zeng L,Waffo AB,Banno K,Xuei X,Doud EH,Dagher PC,Hato T
Wed Feb 01 00:00:00 UTC 2023
Endoplasmic reticulum stress promotes sepsis-induced muscle atrophy via activation of STAT3 and Smad3.
Journal of cellular physiology
Zheng Y,Dai H,Chen R,Zhong Y,Zhou C,Wang Y,Zhan C,Luo J
Wed Mar 01 00:00:00 UTC 2023
Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response.
Glia
Chen Y,Quan S,Patil V,Kunjamma RB,Tokars HM,Leisten ED,Joy G,Wills S,Chan JR,Wong YC,Popko B
Fri Sep 01 00:00:00 UTC 2023
Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.
Molecular biology reports
Erzurumlu Y,Dogan HK,Catakli D
Wed Feb 01 00:00:00 UTC 2023
1,25(OH)2 D3 induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.
Cellular signalling
Erzurumlu Y,Aydogdu E,Dogan HK,Catakli D,Muhammed MT,Buyuksandic B
Wed Mar 01 00:00:00 UTC 2023
An RNA stem-loop functions in conjunction with an upstream open reading frame to direct preferential translation in the integrated stress response.
The Journal of biological chemistry
Amin PH,Carlson KR,Wek RC
Wed Feb 01 00:00:00 UTC 2023
Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition.
Bioorganic & medicinal chemistry
Jiang L,Xu L,Zheng L,Wang Y,Zhuang M,Yang D
Sat Oct 01 00:00:00 UTC 2022
All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal.
Life science alliance
Adachi Y,Masuda M,Sakakibara I,Uchida T,Niida Y,Mori Y,Kamei Y,Okumura Y,Ohminami H,Ohnishi K,Yamanaka-Okumura H,Nikawa T,Taketani Y
Tue Mar 01 00:00:00 UTC 2022
All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal.
Life science alliance
Adachi Y,Masuda M,Sakakibara I,Uchida T,Niida Y,Mori Y,Kamei Y,Okumura Y,Ohminami H,Ohnishi K,Yamanaka-Okumura H,Nikawa T,Taketani Y
Tue Mar 01 00:00:00 UTC 2022
Temporal control of the integrated stress response by a stochastic molecular switch.
Science advances
Klein P,Kallenberger SM,Roth H,Roth K,Ly-Hartig TBN,Magg V,Aleš J,Talemi SR,Qiang Y,Wolf S,Oleksiuk O,Kurilov R,Di Ventura B,Bartenschlager R,Eils R,Rohr K,Hamprecht FA,Höfer T,Fackler OT,Stoecklin G,Ruggieri A
Fri Mar 25 00:00:00 UTC 2022
Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation.
Microbiology spectrum
Li H,Li W,Zhang S,Qiu M,Li Z,Lin Y,Tan J,Qiao W
Wed Feb 23 00:00:00 UTC 2022
Impaired Restoration of Global Protein Synthesis Contributes to Increased Vulnerability to Acute ER Stress Recovery in Huntington's Disease.
Cellular and molecular neurobiology
Xu H,Bensalel J,Capobianco E,Lu ML,Wei J
Tue Nov 01 00:00:00 UTC 2022
Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
Cell reports
Krokowski D,Jobava R,Szkop KJ,Chen CW,Fu X,Venus S,Guan BJ,Wu J,Gao Z,Banaszuk W,Tchorzewski M,Mu T,Ropelewski P,Merrick WC,Mao Y,Sevval AI,Miranda H,Qian SB,Manifava M,Ktistakis NT,Vourekas A,Jankowsky E,Topisirovic I,Larsson O,Hatzoglou M
Tue Jul 19 00:00:00 UTC 2022
Selective activation of cannabinoid receptor-2 reduces white matter injury via PERK signaling in a rat model of traumatic brain injury.
Experimental neurology
Li L,Luo Q,Shang B,Yang X,Zhang Y,Pan Q,Wu N,Tang W,Du D,Sun X,Jiang L
Sat Jan 01 00:00:00 UTC 2022
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis.
eLife
Cordova RA,Misra J,Amin PH,Klunk AJ,Damayanti NP,Carlson KR,Elmendorf AJ,Kim HG,Mirek ET,Elzey BD,Miller MJ,Dong XC,Cheng L,Anthony TG,Pili R,Wek RC,Staschke KA
Thu Sep 15 00:00:00 UTC 2022
A systems biological analysis of the ATF4-GADD34-CHOP regulatory triangle upon endoplasmic reticulum stress.
FEBS open bio
Márton M,Bánhegyi G,Gyöngyösi N,Kálmán EÉ,Pettkó-Szandtner A,Káldi K,Kapuy O
Tue Nov 01 00:00:00 UTC 2022
Inhibition of the integrated stress response reverses oxidative stress damage-induced postoperative cognitive dysfunction.
Frontiers in cellular neuroscience
Jiang L,Dong R,Xu M,Liu Y,Xu J,Ma Z,Xia T,Gu X
Tue Oct 11 00:00:00 UTC 2022
Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response.
The EMBO journal
Pitera AP,Szaruga M,Peak-Chew SY,Wingett SW,Bertolotti A
Wed Jun 01 00:00:00 UTC 2022
Host 5'-3' Exoribonuclease XRN1 Acts as a Proviral Factor for Measles Virus Replication by Downregulating the dsRNA-Activated Kinase PKR.
Journal of virology
BenDavid E,Pfaller CK,Pan Y,Samuel CE,Ma D
Wed Nov 23 00:00:00 UTC 2022
Salubrinal-mediated activation of eIF2α signaling improves oxidative stress-induced BMSCs senescence and senile osteoporosis.
Biochemical and biophysical research communications
Li L,Hu G,Xie R,Yang J,Shi X,Jia Z,Qu X,Wang M,Wu Y
Sat Jun 25 00:00:00 UTC 2022
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
Journal of molecular neuroscience : MN
Chang L,Liu X,Chen J,Liu H,Wang G,Wang G,Liao X,Shen X
Tue Mar 01 00:00:00 UTC 2022
Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway.
Brain and behavior
Liu H,He S,Li C,Wang J,Zou Q,Liao Y,Chen R
Thu Dec 01 00:00:00 UTC 2022
Cysteine dioxygenase 1 attenuates the proliferation via inducing oxidative stress and integrated stress response in gastric cancer cells.
Cell death discovery
Ma G,Zhao Z,Qu Y,Cai F,Liu S,Liang H,Zhang R,Deng J
Fri Dec 16 00:00:00 UTC 2022
Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells.
Science advances
Datta C,Truesdell SS,Wu KQ,Bukhari SIA,Ngue H,Buchanan B,Le Tonqueze O,Lee S,Kollu S,Granovetter MA,Boukhali M,Kreuzer J,Batool MS,Balaj L,Haas W,Vasudevan S
Fri Oct 28 00:00:00 UTC 2022
Signaling by the integrated stress response kinase PKR is fine-tuned by dynamic clustering.
The Journal of cell biology
Zappa F,Muniozguren NL,Wilson MZ,Costello MS,Ponce-Rojas JC,Acosta-Alvear D
Mon Jul 04 00:00:00 UTC 2022
GCN2 kinase activation by ATP-competitive kinase inhibitors.
Nature chemical biology
Tang CP,Clark O,Ferrarone JR,Campos C,Lalani AS,Chodera JD,Intlekofer AM,Elemento O,Mellinghoff IK
Tue Feb 01 00:00:00 UTC 2022
eIF2B-capturing viral protein NSs suppresses the integrated stress response.
Nature communications
Kashiwagi K,Shichino Y,Osaki T,Sakamoto A,Nishimoto M,Takahashi M,Mito M,Weber F,Ikeuchi Y,Iwasaki S,Ito T
Tue Dec 07 00:00:00 UTC 2021
Activation of the Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Pathway of the Unfolded Protein Response after Experimental Traumatic Brain Injury and Treatment with a PERK Inhibitor.
Neurotrauma reports
Brady RD,Bird S,Sun M,Yamakawa GR,Major BP,Mychasiuk R,O'Brien TJ,McDonald SJ,Shultz SR
Thu Jul 29 00:00:00 UTC 2021
Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis.
Communications biology
Al-Yacoub N,Colak D,Mahmoud SA,Hammonds M,Muhammed K,Al-Harazi O,Assiri AM,Al-Buraiki J,Al-Habeeb W,Poizat C
Fri Jul 16 00:00:00 UTC 2021
The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids.
The Journal of biological chemistry
Miles RR,Amin PH,Diaz MB,Misra J,Aukerman E,Das A,Ghosh N,Guith T,Knierman MD,Roy S,Spandau DF,Wek RC
Mon Nov 01 00:00:00 UTC 2021
LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer.
Nature cancer
Rudalska R,Harbig J,Snaebjornsson MT,Klotz S,Zwirner S,Taranets L,Heinzmann F,Kronenberger T,Forster M,Cui W,D'Artista L,Einig E,Hinterleitner M,Schmitz W,Dylawerska A,Kang TW,Poso A,Rosenfeldt MT,Malek NP,Bitzer M,Laufer S,Pichler BJ,Popov N,Schulze A,Zender L,Dauch D
Mon Feb 01 00:00:00 UTC 2021
Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
Frontiers in veterinary science
Alfred N,Qian B,Qin X,Yin X,Prajapati M,Dou Y,Li Y,Zhang Z
Sat Jul 24 00:00:00 UTC 2021
Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
Frontiers in veterinary science
Alfred N,Qian B,Qin X,Yin X,Prajapati M,Dou Y,Li Y,Zhang Z
Sat Jul 24 00:00:00 UTC 2021
Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons.
EBioMedicine
Arioka Y,Shishido E,Kushima I,Suzuki T,Saito R,Aiba A,Mori D,Ozaki N
Fri Jan 01 00:00:00 UTC 2021
Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.
Scientific reports
Monkley S,Overed-Sayer C,Parfrey H,Rassl D,Crowther D,Escudero-Ibarz L,Davis N,Carruthers A,Berks R,Coetzee M,Kolosionek E,Karlsson M,Griffin LR,Clausen M,Belfield G,Hogaboam CM,Murray LA
Wed Nov 03 00:00:00 UTC 2021
GADD34-mediated dephosphorylation of eIF2α facilitates pseudorabies virus replication by maintaining de novo protein synthesis.
Veterinary research
Zhu T,Jiang X,Xin H,Zheng X,Xue X,Chen JL,Qi B
Mon Dec 20 00:00:00 UTC 2021
The kynurenine derivative 3-HAA sensitizes hepatocellular carcinoma to sorafenib by upregulating phosphatases.
Theranostics
Gan G,Shi Z,Shangguan C,Zhang J,Yuan Y,Chen L,Liu W,Li B,Meng S,Xiong W,Mi J
Fri Jul 30 00:00:00 UTC 2021
Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation.
Nature neuroscience
Shrestha P,Ayata P,Herrero-Vidal P,Longo F,Gastone A,LeDoux JE,Heintz N,Klann E
Sat Feb 01 00:00:00 UTC 2020
Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.
Molecular cell
Young-Baird SK,Lourenço MB,Elder MK,Klann E,Liebau S,Dever TE
Thu Feb 20 00:00:00 UTC 2020
Pseudorabies virus infection inhibits stress granules formation via dephosphorylating eIF2α.
Veterinary microbiology
Xu S,Chen D,Chen D,Hu Q,Zhou L,Ge X,Han J,Guo X,Yang H
Sat Aug 01 00:00:00 UTC 2020
Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.
Neuron
Smith HL,Freeman OJ,Butcher AJ,Holmqvist S,Humoud I,Schätzl T,Hughes DT,Verity NC,Swinden DP,Hayes J,de Weerd L,Rowitch DH,Franklin RJM,Mallucci GR
Wed Mar 04 00:00:00 UTC 2020
Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.
Molecular cell
Gokhale NS,McIntyre ABR,Mattocks MD,Holley CL,Lazear HM,Mason CE,Horner SM
Thu Feb 06 00:00:00 UTC 2020
The endoplasmic reticulum stress induced by tunicamycin affects the viability and autophagy activity of chondrocytes.
Journal of clinical laboratory analysis
Wu H,Meng Z,Jiao Y,Ren Y,Yang X,Liu H,Wang R,Cui Y,Pan L,Cao Y
Thu Oct 01 00:00:00 UTC 2020
Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor.
International journal of molecular sciences
Rao L,Xu Y,Reineke LC,Bhattacharya A,Tyryshkin A,Shin JN,Eissa NT
Wed Jun 17 00:00:00 UTC 2020
GADD34 is a modulator of autophagy during starvation.
Science advances
Gambardella G,Staiano L,Moretti MN,De Cegli R,Fagnocchi L,Di Tullio G,Polletti S,Braccia C,Armirotti A,Zippo A,Ballabio A,De Matteis MA,di Bernardo D
Tue Sep 01 00:00:00 UTC 2020
A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.
The FEBS journal
Sicari D,Delaunay-Moisan A,Combettes L,Chevet E,Igbaria A
Wed Jan 01 00:00:00 UTC 2020
A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.
The FEBS journal
Sicari D,Delaunay-Moisan A,Combettes L,Chevet E,Igbaria A
Wed Jan 01 00:00:00 UTC 2020
A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.
The FEBS journal
Sicari D,Delaunay-Moisan A,Combettes L,Chevet E,Igbaria A
Wed Jan 01 00:00:00 UTC 2020
A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.
The FEBS journal
Sicari D,Delaunay-Moisan A,Combettes L,Chevet E,Igbaria A
Wed Jan 01 00:00:00 UTC 2020
CReP mediates selective translation initiation at the endoplasmic reticulum.
Science advances
Kastan JP,Dobrikova EY,Bryant JD,Gromeier M
Mon Jun 01 00:00:00 UTC 2020
Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease.
Science translational medicine
Lu Y,Sun Y,Liu Z,Lu Y,Zhu X,Lan B,Mi Z,Dang L,Li N,Zhan W,Tan L,Pi J,Xiong H,Zhang L,Chen Y
Wed Jul 29 00:00:00 UTC 2020
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Cell proliferation
Tang Q,Ren L,Liu J,Li W,Zheng X,Wang J,Du G
Wed Jan 01 00:00:00 UTC 2020
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Cell proliferation
Tang Q,Ren L,Liu J,Li W,Zheng X,Wang J,Du G
Wed Jan 01 00:00:00 UTC 2020
Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress.
Cell cycle (Georgetown, Tex.)
Wang F,Liu L,Tong Y,Li L,Liu Y,Gao WQ
Sun Mar 01 00:00:00 UTC 2020
GADD34 attenuates HIV-1 replication by viral 5'-UTR TAR RNA-mediated translational inhibition.
Virology
Ishaq M,Marshall H,Natarajan V
Wed Jan 15 00:00:00 UTC 2020
Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus.
PLoS pathogens
Gao P,Chai Y,Song J,Liu T,Chen P,Zhou L,Ge X,Guo X,Han J,Yang H
Fri Nov 01 00:00:00 UTC 2019
Targeting Super-Enhancer-Driven Oncogenic Transcription by CDK7 Inhibition in Anaplastic Thyroid Carcinoma.
Thyroid : official journal of the American Thyroid Association
Cao X,Dang L,Zheng X,Lu Y,Lu Y,Ji R,Zhang T,Ruan X,Zhi J,Hou X,Yi X,Li MJ,Gu T,Gao M,Zhang L,Chen Y
Sat Jun 01 00:00:00 UTC 2019
Targeting Super-Enhancer-Driven Oncogenic Transcription by CDK7 Inhibition in Anaplastic Thyroid Carcinoma.
Thyroid : official journal of the American Thyroid Association
Cao X,Dang L,Zheng X,Lu Y,Lu Y,Ji R,Zhang T,Ruan X,Zhi J,Hou X,Yi X,Li MJ,Gu T,Gao M,Zhang L,Chen Y
Sat Jun 01 00:00:00 UTC 2019
Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice.
Scientific reports
Patel V,Bidault G,Chambers JE,Carobbio S,Everden AJT,Garcés C,Dalton LE,Gribble FM,Vidal-Puig A,Marciniak SJ
Wed Feb 27 00:00:00 UTC 2019
Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress.
Molecular biology of the cell
Samluk L,Urbanska M,Kisielewska K,Mohanraj K,Kim MJ,Machnicka K,Liszewska E,Jaworski J,Chacinska A
Mon Jul 15 00:00:00 UTC 2019
The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus.
iScience
Jasenosky LD,Cadena C,Mire CE,Borisevich V,Haridas V,Ranjbar S,Nambu A,Bavari S,Soloveva V,Sadukhan S,Cassell GH,Geisbert TW,Hur S,Goldfeld AE
Fri Sep 27 00:00:00 UTC 2019
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
Nature medicine
Hyer ML,Milhollen MA,Ciavarri J,Fleming P,Traore T,Sappal D,Huck J,Shi J,Gavin J,Brownell J,Yang Y,Stringer B,Griffin R,Bruzzese F,Soucy T,Duffy J,Rabino C,Riceberg J,Hoar K,Lublinsky A,Menon S,Sintchak M,Bump N,Pulukuri SM,Langston S,Tirrell S,Kuranda M,Veiby P,Newcomb J,Li P,Wu JT,Powe J,Dick LR,Greenspan P,Galvin K,Manfredi M,Claiborne C,Amidon BS,Bence NF
Thu Feb 01 00:00:00 UTC 2018
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
Nature medicine
Hyer ML,Milhollen MA,Ciavarri J,Fleming P,Traore T,Sappal D,Huck J,Shi J,Gavin J,Brownell J,Yang Y,Stringer B,Griffin R,Bruzzese F,Soucy T,Duffy J,Rabino C,Riceberg J,Hoar K,Lublinsky A,Menon S,Sintchak M,Bump N,Pulukuri SM,Langston S,Tirrell S,Kuranda M,Veiby P,Newcomb J,Li P,Wu JT,Powe J,Dick LR,Greenspan P,Galvin K,Manfredi M,Claiborne C,Amidon BS,Bence NF
Thu Feb 01 00:00:00 UTC 2018
Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.
Cell
Krzyzosiak A,Sigurdardottir A,Luh L,Carrara M,Das I,Schneider K,Bertolotti A
Thu Aug 23 00:00:00 UTC 2018
Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.
Cell
Krzyzosiak A,Sigurdardottir A,Luh L,Carrara M,Das I,Schneider K,Bertolotti A
Thu Aug 23 00:00:00 UTC 2018
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.
Molecular cell
Chang TK,Lawrence DA,Lu M,Tan J,Harnoss JM,Marsters SA,Liu P,Sandoval W,Martin SE,Ashkenazi A
Thu Aug 16 00:00:00 UTC 2018
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.
Molecular cell
Chang TK,Lawrence DA,Lu M,Tan J,Harnoss JM,Marsters SA,Liu P,Sandoval W,Martin SE,Ashkenazi A
Thu Aug 16 00:00:00 UTC 2018
Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.
Cell death and differentiation
Lee IC,Ho XY,George SE,Goh CW,Sundaram JR,Pang KKL,Luo W,Yusoff P,Sze NSK,Shenolikar S
Thu Feb 01 00:00:00 UTC 2018
Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.
Cell death and differentiation
Lee IC,Ho XY,George SE,Goh CW,Sundaram JR,Pang KKL,Luo W,Yusoff P,Sze NSK,Shenolikar S
Thu Feb 01 00:00:00 UTC 2018
EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.
RNA (New York, N.Y.)
Moon SL,Parker R
Fri Jun 01 00:00:00 UTC 2018
EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.
RNA (New York, N.Y.)
Moon SL,Parker R
Fri Jun 01 00:00:00 UTC 2018
Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease.
Experimental neurology
Sun X,Aimé P,Dai D,Ramalingam N,Crary JF,Burke RE,Greene LA,Levy OA
Tue May 01 00:00:00 UTC 2018
Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease.
Experimental neurology
Sun X,Aimé P,Dai D,Ramalingam N,Crary JF,Burke RE,Greene LA,Levy OA
Tue May 01 00:00:00 UTC 2018
Activating Transcription Factor-6α Deletion Modulates the Endoplasmic Reticulum Stress Response after Spinal Cord Injury but Does Not Affect Locomotor Recovery.
Journal of neurotrauma
Saraswat Ohri S,Mullins A,Hetman M,Whittemore SR
Thu Feb 01 00:00:00 UTC 2018
Activating Transcription Factor-6α Deletion Modulates the Endoplasmic Reticulum Stress Response after Spinal Cord Injury but Does Not Affect Locomotor Recovery.
Journal of neurotrauma
Saraswat Ohri S,Mullins A,Hetman M,Whittemore SR
Thu Feb 01 00:00:00 UTC 2018
Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes.
Molecular biology of the cell
Collier AE,Spandau DF,Wek RC
Mon Jan 01 00:00:00 UTC 2018
Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes.
Molecular biology of the cell
Collier AE,Spandau DF,Wek RC
Mon Jan 01 00:00:00 UTC 2018
Impact of GADD34 on Apoptosis of Tonsillar Mononuclear Cells from IgA Nephropathy Patients by Regulating Eif2α Phosphorylation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Peng X,Yang T,He L,Chen X,Jiang Y,Zhang H,Liu H,Peng Y
Tue Dec 11 00:00:00 UTC 2018
Impact of GADD34 on Apoptosis of Tonsillar Mononuclear Cells from IgA Nephropathy Patients by Regulating Eif2α Phosphorylation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Peng X,Yang T,He L,Chen X,Jiang Y,Zhang H,Liu H,Peng Y
Tue Dec 11 00:00:00 UTC 2018
Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir-bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death.
Oncogene
Johnson CE,Dunlop EA,Seifan S,McCann HD,Hay T,Parfitt GJ,Jones AT,Giles PJ,Shen MH,Sampson JR,Errington RJ,Davies DM,Tee AR
Thu Nov 01 00:00:00 UTC 2018
ICE1 promotes the link between splicing and nonsense-mediated mRNA decay.
eLife
Baird TD,Cheng KC,Chen YC,Buehler E,Martin SE,Inglese J,Hogg JR
Mon Mar 12 00:00:00 UTC 2018
ICE1 promotes the link between splicing and nonsense-mediated mRNA decay.
eLife
Baird TD,Cheng KC,Chen YC,Buehler E,Martin SE,Inglese J,Hogg JR
Mon Mar 12 00:00:00 UTC 2018
Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2α and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats.
Cell reports
Melas PA,Qvist JS,Deidda M,Upreti C,Wei YB,Sanna F,Fratta W,Scherma M,Fadda P,Kandel DB,Kandel ER
Tue Mar 13 00:00:00 UTC 2018
Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2α and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats.
Cell reports
Melas PA,Qvist JS,Deidda M,Upreti C,Wei YB,Sanna F,Fratta W,Scherma M,Fadda P,Kandel DB,Kandel ER
Tue Mar 13 00:00:00 UTC 2018
Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.
Respiratory research
Dolinay T,Aonbangkhen C,Zacharias W,Cantu E,Pogoriler J,Stablow A,Lawrence GG,Suzuki Y,Chenoweth DM,Morrisey E,Christie JD,Beers MF,Margulies SS
Wed Aug 22 00:00:00 UTC 2018
Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.
Respiratory research
Dolinay T,Aonbangkhen C,Zacharias W,Cantu E,Pogoriler J,Stablow A,Lawrence GG,Suzuki Y,Chenoweth DM,Morrisey E,Christie JD,Beers MF,Margulies SS
Wed Aug 22 00:00:00 UTC 2018
Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.
Respiratory research
Dolinay T,Aonbangkhen C,Zacharias W,Cantu E,Pogoriler J,Stablow A,Lawrence GG,Suzuki Y,Chenoweth DM,Morrisey E,Christie JD,Beers MF,Margulies SS
Wed Aug 22 00:00:00 UTC 2018
Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.
The EMBO journal
Dalet A,Argüello RJ,Combes A,Spinelli L,Jaeger S,Fallet M,Vu Manh TP,Mendes A,Perego J,Reverendo M,Camosseto V,Dalod M,Weil T,Santos MA,Gatti E,Pierre P
Wed Mar 15 00:00:00 UTC 2017
Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.
The EMBO journal
Dalet A,Argüello RJ,Combes A,Spinelli L,Jaeger S,Fallet M,Vu Manh TP,Mendes A,Perego J,Reverendo M,Camosseto V,Dalod M,Weil T,Santos MA,Gatti E,Pierre P
Wed Mar 15 00:00:00 UTC 2017
Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly.
Cell death & disease
Shelkovnikova TA,Dimasi P,Kukharsky MS,An H,Quintiero A,Schirmer C,Buée L,Galas MC,Buchman VL
Thu May 11 00:00:00 UTC 2017
Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly.
Cell death & disease
Shelkovnikova TA,Dimasi P,Kukharsky MS,An H,Quintiero A,Schirmer C,Buée L,Galas MC,Buchman VL
Thu May 11 00:00:00 UTC 2017
Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells.
Oncotarget
Dunlop EA,Johnson CE,Wiltshire M,Errington RJ,Tee AR
Tue Jul 25 00:00:00 UTC 2017
Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells.
Oncotarget
Dunlop EA,Johnson CE,Wiltshire M,Errington RJ,Tee AR
Tue Jul 25 00:00:00 UTC 2017
PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.
eLife
Crespillo-Casado A,Chambers JE,Fischer PM,Marciniak SJ,Ron D
Thu Apr 27 00:00:00 UTC 2017
PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.
eLife
Crespillo-Casado A,Chambers JE,Fischer PM,Marciniak SJ,Ron D
Thu Apr 27 00:00:00 UTC 2017
An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.
Proceedings of the National Academy of Sciences of the United States of America
De Gassart A,Bujisic B,Zaffalon L,Decosterd LA,Di Micco A,Frera G,Tallant R,Martinon F
Tue Jan 12 00:00:00 UTC 2016
An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.
Proceedings of the National Academy of Sciences of the United States of America
De Gassart A,Bujisic B,Zaffalon L,Decosterd LA,Di Micco A,Frera G,Tallant R,Martinon F
Tue Jan 12 00:00:00 UTC 2016
Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sidoli M,Musner N,Silvestri N,Ungaro D,D'Antonio M,Cavener DR,Feltri ML,Wrabetz L
Wed Nov 02 00:00:00 UTC 2016
Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sidoli M,Musner N,Silvestri N,Ungaro D,D'Antonio M,Cavener DR,Feltri ML,Wrabetz L
Wed Nov 02 00:00:00 UTC 2016
Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression.
The Journal of biological chemistry
Young SK,Shao Y,Bidwell JP,Wek RC
Fri Jun 24 00:00:00 UTC 2016
Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression.
The Journal of biological chemistry
Young SK,Shao Y,Bidwell JP,Wek RC
Fri Jun 24 00:00:00 UTC 2016
Oral proteasome inhibitor with strong preclinical efficacy in myeloma models.
BMC cancer
Park J,Park E,Jung CK,Kang SW,Kim BG,Jung Y,Kim TH,Lim JY,Lee SE,Min CK,Won KA
Thu Mar 24 00:00:00 UTC 2016
Oral proteasome inhibitor with strong preclinical efficacy in myeloma models.
BMC cancer
Park J,Park E,Jung CK,Kang SW,Kim BG,Jung Y,Kim TH,Lim JY,Lee SE,Min CK,Won KA
Thu Mar 24 00:00:00 UTC 2016
Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.
ASN neuro
Musner N,Sidoli M,Zambroni D,Del Carro U,Ungaro D,D'Antonio M,Feltri ML,Wrabetz L
Tue Dec 13 00:00:00 UTC 2016
Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.
ASN neuro
Musner N,Sidoli M,Zambroni D,Del Carro U,Ungaro D,D'Antonio M,Feltri ML,Wrabetz L
Tue Dec 13 00:00:00 UTC 2016
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.
Science (New York, N.Y.)
Das I,Krzyzosiak A,Schneider K,Wrabetz L,D'Antonio M,Barry N,Sigurdardottir A,Bertolotti A
Fri Apr 10 00:00:00 UTC 2015
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.
Science (New York, N.Y.)
Das I,Krzyzosiak A,Schneider K,Wrabetz L,D'Antonio M,Barry N,Sigurdardottir A,Bertolotti A
Fri Apr 10 00:00:00 UTC 2015
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.
Acta neuropathologica
Radford H,Moreno JA,Verity N,Halliday M,Mallucci GR
Sun Nov 01 00:00:00 UTC 2015
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.
Acta neuropathologica
Radford H,Moreno JA,Verity N,Halliday M,Mallucci GR
Sun Nov 01 00:00:00 UTC 2015
Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.
eLife
Chambers JE,Dalton LE,Clarke HJ,Malzer E,Dominicus CS,Patel V,Moorhead G,Ron D,Marciniak SJ
Mon Mar 16 00:00:00 UTC 2015
Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.
eLife
Chambers JE,Dalton LE,Clarke HJ,Malzer E,Dominicus CS,Patel V,Moorhead G,Ron D,Marciniak SJ
Mon Mar 16 00:00:00 UTC 2015
Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.
eLife
Chambers JE,Dalton LE,Clarke HJ,Malzer E,Dominicus CS,Patel V,Moorhead G,Ron D,Marciniak SJ
Mon Mar 16 00:00:00 UTC 2015
Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells.
PLoS pathogens
van 't Wout EF,van Schadewijk A,van Boxtel R,Dalton LE,Clarke HJ,Tommassen J,Marciniak SJ,Hiemstra PS
Mon Jun 01 00:00:00 UTC 2015
DNA Damage Regulates Translation through β-TRCP Targeting of CReP.
PLoS genetics
Loveless TB,Topacio BR,Vashisht AA,Galaang S,Ulrich KM,Young BD,Wohlschlegel JA,Toczyski DP
Mon Jun 01 00:00:00 UTC 2015
DNA Damage Regulates Translation through β-TRCP Targeting of CReP.
PLoS genetics
Loveless TB,Topacio BR,Vashisht AA,Galaang S,Ulrich KM,Young BD,Wohlschlegel JA,Toczyski DP
Mon Jun 01 00:00:00 UTC 2015
Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.
The Journal of biological chemistry
Young SK,Willy JA,Wu C,Sachs MS,Wek RC
Fri Nov 20 00:00:00 UTC 2015
Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.
The Journal of biological chemistry
Young SK,Willy JA,Wu C,Sachs MS,Wek RC
Fri Nov 20 00:00:00 UTC 2015
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Nature communications
Wu H,Wei L,Fan F,Ji S,Zhang S,Geng J,Hong L,Fan X,Chen Q,Tian J,Jiang M,Sun X,Jin C,Yin ZY,Liu Q,Zhang J,Qin F,Lin KH,Yu JS,Deng X,Wang HR,Zhao B,Johnson RL,Chen L,Zhou D
Thu Feb 19 00:00:00 UTC 2015
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Nature communications
Wu H,Wei L,Fan F,Ji S,Zhang S,Geng J,Hong L,Fan X,Chen Q,Tian J,Jiang M,Sun X,Jin C,Yin ZY,Liu Q,Zhang J,Qin F,Lin KH,Yu JS,Deng X,Wang HR,Zhao B,Johnson RL,Chen L,Zhou D
Thu Feb 19 00:00:00 UTC 2015
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Nature communications
Wu H,Wei L,Fan F,Ji S,Zhang S,Geng J,Hong L,Fan X,Chen Q,Tian J,Jiang M,Sun X,Jin C,Yin ZY,Liu Q,Zhang J,Qin F,Lin KH,Yu JS,Deng X,Wang HR,Zhao B,Johnson RL,Chen L,Zhou D
Thu Feb 19 00:00:00 UTC 2015
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Nature communications
Wu H,Wei L,Fan F,Ji S,Zhang S,Geng J,Hong L,Fan X,Chen Q,Tian J,Jiang M,Sun X,Jin C,Yin ZY,Liu Q,Zhang J,Qin F,Lin KH,Yu JS,Deng X,Wang HR,Zhao B,Johnson RL,Chen L,Zhou D
Thu Feb 19 00:00:00 UTC 2015
Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.
The EMBO journal
Besche HC,Sha Z,Kukushkin NV,Peth A,Hock EM,Kim W,Gygi S,Gutierrez JA,Liao H,Dick L,Goldberg AL
Fri May 16 00:00:00 UTC 2014
Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.
The EMBO journal
Besche HC,Sha Z,Kukushkin NV,Peth A,Hock EM,Kim W,Gygi S,Gutierrez JA,Liao H,Dick L,Goldberg AL
Fri May 16 00:00:00 UTC 2014
The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa.
Cell death & disease
Parfitt DA,Aguila M,McCulley CH,Bevilacqua D,Mendes HF,Athanasiou D,Novoselov SS,Kanuga N,Munro PM,Coffey PJ,Kalmar B,Greensmith L,Cheetham ME
Thu May 22 00:00:00 UTC 2014
The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa.
Cell death & disease
Parfitt DA,Aguila M,McCulley CH,Bevilacqua D,Mendes HF,Athanasiou D,Novoselov SS,Kanuga N,Munro PM,Coffey PJ,Kalmar B,Greensmith L,Cheetham ME
Thu May 22 00:00:00 UTC 2014
Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.
PloS one
Sadleir KR,Eimer WA,Kaufman RJ,Osten P,Vassar R
Wed Oct 14 00:00:00 UTC 2015
Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.
PloS one
Sadleir KR,Eimer WA,Kaufman RJ,Osten P,Vassar R
Wed Oct 14 00:00:00 UTC 2015
Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism.
Blood
Hahn CK,Lowrey CH
Thu Jul 25 00:00:00 UTC 2013
Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism.
Blood
Hahn CK,Lowrey CH
Thu Jul 25 00:00:00 UTC 2013
The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma.
British journal of cancer
Dalton LE,Clarke HJ,Knight J,Lawson MH,Wason J,Lomas DA,Howat WJ,Rintoul RC,Rassl DM,Marciniak SJ
Tue Apr 02 00:00:00 UTC 2013
The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma.
British journal of cancer
Dalton LE,Clarke HJ,Knight J,Lawson MH,Wason J,Lomas DA,Howat WJ,Rintoul RC,Rassl DM,Marciniak SJ
Tue Apr 02 00:00:00 UTC 2013
The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Nagelkerke A,Bussink J,van der Kogel AJ,Sweep FC,Span PN
Sun Sep 01 00:00:00 UTC 2013
The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Nagelkerke A,Bussink J,van der Kogel AJ,Sweep FC,Span PN
Sun Sep 01 00:00:00 UTC 2013
The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation.
Cell structure and function
Ozasa R,Okada T,Nadanaka S,Nagamine T,Zyryanova A,Harding H,Ron D,Mori K
Mon Apr 07 00:00:00 UTC 2014
The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation.
Cell structure and function
Ozasa R,Okada T,Nadanaka S,Nagamine T,Zyryanova A,Harding H,Ron D,Mori K
Mon Apr 07 00:00:00 UTC 2014
p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.
The Journal of biological chemistry
Thomas SE,Malzer E,Ordóñez A,Dalton LE,van T Wout EFA,Liniker E,Crowther DC,Lomas DA,Marciniak SJ
Fri Mar 15 00:00:00 UTC 2013
p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.
The Journal of biological chemistry
Thomas SE,Malzer E,Ordóñez A,Dalton LE,van T Wout EFA,Liniker E,Crowther DC,Lomas DA,Marciniak SJ
Fri Mar 15 00:00:00 UTC 2013
Sustained translational repression by eIF2α-P mediates prion neurodegeneration.
Nature
Moreno JA,Radford H,Peretti D,Steinert JR,Verity N,Martin MG,Halliday M,Morgan J,Dinsdale D,Ortori CA,Barrett DA,Tsaytler P,Bertolotti A,Willis AE,Bushell M,Mallucci GR
Sun May 06 00:00:00 UTC 2012
Sustained translational repression by eIF2α-P mediates prion neurodegeneration.
Nature
Moreno JA,Radford H,Peretti D,Steinert JR,Verity N,Martin MG,Halliday M,Morgan J,Dinsdale D,Ortori CA,Barrett DA,Tsaytler P,Bertolotti A,Willis AE,Bushell M,Mallucci GR
Sun May 06 00:00:00 UTC 2012
Sustained translational repression by eIF2α-P mediates prion neurodegeneration.
Nature
Moreno JA,Radford H,Peretti D,Steinert JR,Verity N,Martin MG,Halliday M,Morgan J,Dinsdale D,Ortori CA,Barrett DA,Tsaytler P,Bertolotti A,Willis AE,Bushell M,Mallucci GR
Sun May 06 00:00:00 UTC 2012
Sustained translational repression by eIF2α-P mediates prion neurodegeneration.
Nature
Moreno JA,Radford H,Peretti D,Steinert JR,Verity N,Martin MG,Halliday M,Morgan J,Dinsdale D,Ortori CA,Barrett DA,Tsaytler P,Bertolotti A,Willis AE,Bushell M,Mallucci GR
Sun May 06 00:00:00 UTC 2012
Failure of amino acid homeostasis causes cell death following proteasome inhibition.
Molecular cell
Suraweera A,Münch C,Hanssum A,Bertolotti A
Fri Oct 26 00:00:00 UTC 2012
Failure of amino acid homeostasis causes cell death following proteasome inhibition.
Molecular cell
Suraweera A,Münch C,Hanssum A,Bertolotti A
Fri Oct 26 00:00:00 UTC 2012
Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection.
PLoS pathogens
Clavarino G,Cláudio N,Couderc T,Dalet A,Judith D,Camosseto V,Schmidt EK,Wenger T,Lecuit M,Gatti E,Pierre P
Thu Nov 08 00:00:00 UTC 2012
Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection.
PLoS pathogens
Clavarino G,Cláudio N,Couderc T,Dalet A,Judith D,Camosseto V,Schmidt EK,Wenger T,Lecuit M,Gatti E,Pierre P
Thu Nov 08 00:00:00 UTC 2012
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis.
Science (New York, N.Y.)
Tsaytler P,Harding HP,Ron D,Bertolotti A
Fri Apr 01 00:00:00 UTC 2011
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis.
Science (New York, N.Y.)
Tsaytler P,Harding HP,Ron D,Bertolotti A
Fri Apr 01 00:00:00 UTC 2011
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis.
Science (New York, N.Y.)
Tsaytler P,Harding HP,Ron D,Bertolotti A
Fri Apr 01 00:00:00 UTC 2011
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis.
Science (New York, N.Y.)
Tsaytler P,Harding HP,Ron D,Bertolotti A
Fri Apr 01 00:00:00 UTC 2011
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.
Cancer research
Kupperman E,Lee EC,Cao Y,Bannerman B,Fitzgerald M,Berger A,Yu J,Yang Y,Hales P,Bruzzese F,Liu J,Blank J,Garcia K,Tsu C,Dick L,Fleming P,Yu L,Manfredi M,Rolfe M,Bolen J
Mon Mar 01 00:00:00 UTC 2010
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.
Cancer research
Kupperman E,Lee EC,Cao Y,Bannerman B,Fitzgerald M,Berger A,Yu J,Yang Y,Hales P,Bruzzese F,Liu J,Blank J,Garcia K,Tsu C,Dick L,Fleming P,Yu L,Manfredi M,Rolfe M,Bolen J
Mon Mar 01 00:00:00 UTC 2010
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.
Cancer research
Kupperman E,Lee EC,Cao Y,Bannerman B,Fitzgerald M,Berger A,Yu J,Yang Y,Hales P,Bruzzese F,Liu J,Blank J,Garcia K,Tsu C,Dick L,Fleming P,Yu L,Manfredi M,Rolfe M,Bolen J
Mon Mar 01 00:00:00 UTC 2010
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.
Cancer research
Kupperman E,Lee EC,Cao Y,Bannerman B,Fitzgerald M,Berger A,Yu J,Yang Y,Hales P,Bruzzese F,Liu J,Blank J,Garcia K,Tsu C,Dick L,Fleming P,Yu L,Manfredi M,Rolfe M,Bolen J
Mon Mar 01 00:00:00 UTC 2010
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.
Nature
Soucy TA,Smith PG,Milhollen MA,Berger AJ,Gavin JM,Adhikari S,Brownell JE,Burke KE,Cardin DP,Critchley S,Cullis CA,Doucette A,Garnsey JJ,Gaulin JL,Gershman RE,Lublinsky AR,McDonald A,Mizutani H,Narayanan U,Olhava EJ,Peluso S,Rezaei M,Sintchak MD,Talreja T,Thomas MP,Traore T,Vyskocil S,Weatherhead GS,Yu J,Zhang J,Dick LR,Claiborne CF,Rolfe M,Bolen JB,Langston SP
Thu Apr 09 00:00:00 UTC 2009
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.
Nature
Soucy TA,Smith PG,Milhollen MA,Berger AJ,Gavin JM,Adhikari S,Brownell JE,Burke KE,Cardin DP,Critchley S,Cullis CA,Doucette A,Garnsey JJ,Gaulin JL,Gershman RE,Lublinsky AR,McDonald A,Mizutani H,Narayanan U,Olhava EJ,Peluso S,Rezaei M,Sintchak MD,Talreja T,Thomas MP,Traore T,Vyskocil S,Weatherhead GS,Yu J,Zhang J,Dick LR,Claiborne CF,Rolfe M,Bolen JB,Langston SP
Thu Apr 09 00:00:00 UTC 2009
