Proteintech

GADD34 Recombinant Rabbit Monoclonal Antibody (4K3)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

81250-1-RR

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:16,000
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

Mammalian cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4K3

Immunogen

Recombinant protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Protein A

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: SDEEEGEVKA LGAAEKDGEA ECPPCIPPPS AFLKAWVYWP GEDTEEEEDE EEDEDSDSGS DEEEGEAEAS SSTPATGVFL KSWVYQPGED TEEEEDEDSD TGSAEDEREA ETSASTPPAS AFLKAWVYRP GEDTEEEEDE DVDSEDKEDD SEAALGEAES DPHPSHPDQR AHFRGWGYRP GKETEEEEAA EDWGEAEPCP FRVAIYVPGE KPPPPWAPPR LPLRLQRRLK RPETPTHDPD PETPLKARKV RFSEKVTVHF LAVWAG

Target Information

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Growth arrest and DNA damage-inducible protein GADD34; growth arrest and DNA-damage-inducible 34; myeloid differentiation primary response gene 116; Myeloid differentiation primary response protein MyD116; Myeloid differentiation primary response protein MyD116 homolog; PR15A; Protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A; protein phosphatase 1, regulatory subunit 15A

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Gene Aliases: 9630030H21; GADD34; Myd116; PPP1R15A

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UniProt ID: (Human) O75807, (Mouse) P17564

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Entrez Gene ID: (Human) 23645, (Mouse) 17872

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Function(s)
protein binding protein phosphatase 1 binding protein phosphatase type 1 regulator activity protein kinase binding protein phosphatase type 1 activator activity protein phosphatase regulator activity protein phosphatase binding
Process(es)
regulation of translation apoptotic process positive regulation of gene expression endoplasmic reticulum unfolded protein response negative regulation of phosphoprotein phosphatase activity positive regulation of phosphoprotein phosphatase activity positive regulation of peptidyl-serine phosphorylation response to endoplasmic reticulum stress negative regulation of protein dephosphorylation regulation of translational initiation by eIF2 alpha dephosphorylation positive regulation of transcription from RNA polymerase I promoter regulation of catalytic activity regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation peptidyl-serine dephosphorylation protein localization to endoplasmic reticulum positive regulation of peptidyl-serine dephosphorylation negative regulation of response to endoplasmic reticulum stress negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of protein phosphorylation cellular response to DNA damage stimulus cell cycle arrest aging negative regulation of cell proliferation negative regulation of peptidyl-threonine phosphorylation negative regulation of protein processing positive regulation of translational initiation in response to stress cellular response to UV cellular response to drug response to immobilization stress response to cocaine positive regulation of apoptotic process regulation of angiogenesis negative regulation of cell death intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to antibiotic cellular response to carbohydrate stimulus cellular response to methyl methanesulfonate cellular response to calcium ion starvation response to environmental enrichment cellular response to oxygen-glucose deprivation negative regulation of PERK-mediated unfolded protein response positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation cellular response to desipramine cellular response to cordycepin cellular response to gold(3+) cellular response to methamphetamine hydrochloride
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