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Proteintech
GADD45GIP1 Polyclonal Antibody
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Product Details
16260-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GADD45GIP1 Fusion Protein Ag9299 (1-222 aa encoded by BC013027)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AASVRQARS LLGVAATLAP GSRGYRARPP PRRRPGPRWP DPEDLLTPRW QLGPRYAAKQ FARYGAASGV VPGSLWPSPE QLRELEAEER EWYPSLATMQ ESLRVKQLAE EQKRREREQH IAECMAKMPQ MIVNWQQQQR ENWEKAQADK ERRARLQAEA QELLGYQVDP RSARFQELLQ DLEKKERKRL KEEKQKRKKE ARAAALAAAV AQDPAASGAP SS (1-222 aa encoded by BC013027)
Target Information
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 39S ribosomal protein L59, mitochondrial; CKII beta binding protein 2; CKII beta-associating protein; CR6 interacting factor 1; CR6-interacting factor 1; CRIF1; Growth arrest and DNA damage-inducible proteins-interacting protein 1; growth arrest and DNA-damage-inducible proteins-interacting protein 1; growth arrest and DNA-damage-inducible, gamma interacting protein 1; growth arrest- and DNA damage-inducible GADD45G-interacting protein; Large ribosomal subunit protein mL64; MRP-L59; p53-responsive gene 6 protein; papillomavirus L2 interacting nuclear protein 1; Papillomavirus L2-interacting nuclear protein 1; PLINP
Gene Aliases: 2310040G17Rik; AI425883; CKBBP2; CKbetaBP2; CRIF1; GADD45GIP1; MRP-L59; MRPL59; PLINP; PLINP-1; PLINP1; PRG6
UniProt ID: (Human) Q8TAE8, (Mouse) Q9CR59
Entrez Gene ID: (Human) 90480, (Mouse) 102060
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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