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Abnova
GAK Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 2
GAK Antibody (H00002580-D01P) in WB
Western Blot analysis of GAK expression in transfected 293T cell line (H00002580-T01) by GAK MaxPab polyclonal antibody.
Lane 1: GAK transfected lysate(44.00 KDa).
Lane 2: Non-transfected lysate.
Lane 1: GAK transfected lysate(44.00 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00002580-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GAK (AAH08668.1, 1 a.a. approximately 416 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL LLASPAPPLS VQSTPRGGPP AAADPFGPLL PSSGNNSQPC SNPDLFGEFL NSDSVTVPPS FPSAHSSPPP SCSADFLHLG DLPGEPSKMT ASSSNPDLLG GWAAWTETAA SAVAPTPATE GPLFSPGGQP APCGSQASWT KSQNPDPFAD LGDLSSGLQG SPAGFPPGGF IPKTATTPKG SSSWQTSRPP AQGASWPPQA KPPPKACTQP RPNYASNFSV IGAREERGVR APSFAQKPKV SENDFEDLLS NQGFSSRSDK KGPKTIAEMR KQDLAKDTDP LKLKLLDWIE GKERNIRALL STLHTVLWDG ESRWTPVGMA DLVAPEQVKK HYRRAVLAVH PDKAAGQPYE QHAKMIFMEL NDAWSEFENQ GSRPLF
Target Information
GAK serine/threonine kinase or Cyclin-G-associated kinase was originally identified as a protein that is associated with cyclin G. However, neither CDK5 nor GAK kinase activity is activated by cyclin G nor does GAK affect CDK5 kinase activity. GAK seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: auxilin-2; Cyclin-G-associated kinase; DnaJ homolog subfamily C member 26
Gene Aliases: D130045N16Rik; DNAJ26; DNAJC26; GAK
UniProt ID: (Human) O14976, (Mouse) Q99KY4
Entrez Gene ID: (Human) 2580, (Mouse) 231580
protein phosphorylation
endoplasmic reticulum organization
Golgi organization
cell cycle
epidermal cell differentiation
phosphorylation
intrahepatic bile duct development
cell development
forebrain morphogenesis
establishment of skin barrier
clathrin coat disassembly
clathrin-mediated endocytosis
positive regulation of neural precursor cell proliferation
receptor-mediated endocytosis
negative regulation of neuron projection development
establishment of protein localization to Golgi
establishment of protein localization to plasma membrane
Golgi to lysosome transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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