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Invitrogen
GAK Polyclonal Antibody
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Product Details
PA5-55600
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GAK. Recombinant protein control fragment (Product #RP-95242).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2641823
Product Specific Information
Immunogen sequence: ITRNTTPMYR TPEIIDLYSN FPIGEKQDIW ALGCILYLLC FRQHPFEDGA KLRIVNGKYS IPPHDTQYTV FH
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
Target Information
GAK serine/threonine kinase or Cyclin-G-associated kinase was originally identified as a protein that is associated with cyclin G. However, neither CDK5 nor GAK kinase activity is activated by cyclin G nor does GAK affect CDK5 kinase activity. GAK seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: auxilin-2; Cyclin-G-associated kinase; DnaJ homolog subfamily C member 26
Gene Aliases: DNAJ26; DNAJC26; GAK
UniProt ID: (Human) O14976
Entrez Gene ID: (Human) 2580
protein phosphorylation
receptor-mediated endocytosis
endoplasmic reticulum organization
Golgi organization
cell cycle
negative regulation of neuron projection development
clathrin coat disassembly
clathrin-mediated endocytosis
establishment of protein localization to Golgi
establishment of protein localization to plasma membrane
Golgi to lysosome transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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