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Immunogen sequence: CSNIPLSQP QQGEAMLANF KPRGYSECIV TVGGEERVSR KPTAAMRCMC PLYDPNRQLW IELAPLSMPR INHGVLSAEG FLFVFGGQDE NKQTLSSGEK YDPDANTWTA LPPMNEARHN FGIVEIDGML YILGGEDGEK ELISMECYDI YSKTWTKQPD LTMVRKIGCY AAMKKKIYAM GGGSYGKLFE SVECYDPRTQ QWTAICPLKE RRFGAVACGV AMELYVFGGV RSREDAQGSE MVTCKSEFYH DEFKRWIYLN DQNLCIPASS SFVYGAVPIG ASIYVIGDLD TGTNYDYVRE FKRSTGTWHH TKPLLPSDLR RTGCAALRIA NCKLFRLQLQ QGLFRIRVHS P (248-597 aa encoded by BC044840)
This gene encodes a member of the cytoskeletal BTB/kelch repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: gan; giant axonal neuropathy; Gigaxonin; kelch-like family member 16; Kelch-like protein 16
Gene Aliases: A330045G18; GAN; GAN1; gigaxonin; KLHL16
UniProt ID: (Human) Q9H2C0, (Mouse) Q8CA72
Entrez Gene ID: (Human) 8139, (Rat) 307893, (Mouse) 209239
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