Product References
Multivalent insulin receptor activation using insulin-DNA origami nanostructures.
Nature nanotechnology
Spratt J,Dias JM,Kolonelou C,Kiriako G,Engström E,Petrova E,Karampelias C,Cervenka I,Papanicolaou N,Lentini A,Reinius B,Andersson O,Ambrosetti E,Ruas JL,Teixeira AI
PA1-987 was used in Western Blot to propose insulin nanoscale organization as a design parameter in developing new insulin therapies.
Thu Feb 01 00:00:00 UTC 2024
Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy.
Nature communications
Hussong SA,Banh AQ,Van Skike CE,Dorigatti AO,Hernandez SF,Hart MJ,Ferran B,Makhlouf H,Gaczynska M,Osmulski PA,McAllen SA,Dineley KT,Ungvari Z,Perez VI,Kayed R,Galvan V
PA1-987 was used in Western Blotting to suggest that soluble pathogenic tau aggregates mediate AD-like brain microvascular deficits in a mouse model of tauopathy, which may arise from endothelial cell senescence and eNOS dysfunction triggered by internalization of soluble tau aggregates.
Tue Apr 25 00:00:00 UTC 2023
Novel aminopyridazine derivative of minaprine modified by radiolysis presents potent anti-inflammatory effects in LPS-stimulated RAW 264.7 and DH82 macrophage cells.
Scientific reports
Jeong GH,Lee H,Woo SY,Lee HK,Chung BY,Bai HW
PA1-987 was used in Western Blotting to show a highly enhanced anti-inflammatory capacity inhibited nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 and DH82 macrophage cells.
Wed Jul 05 00:00:00 UTC 2023
Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2.
Nature neuroscience
Dridi H,Liu Y,Reiken S,Liu X,Argyrousi EK,Yuan Q,Miotto MC,Sittenfeld L,Meddar A,Soni RK,Arancio O,Lacampagne A,Marks AR
PA1-987 was used in Western Blot to propose that HF is a systemic illness driven by intracellular Ca2+ leak that includes cardiogenic dementia.
Tue Aug 01 00:00:00 UTC 2023
Intermittent Theta Burst Stimulation Improves Motor and Behavioral Dysfunction through Modulation of NMDA Receptor Subunit Composition in Experimental Model of Parkinson's Disease.
Cells
Zeljkovic Jovanovic M,Stanojevic J,Stevanovic I,Stekic A,Bolland SJ,Jasnic N,Ninkovic M,Zaric Kontic M,Ilic TV,Rodger J,Nedeljkovic N,Dragic M
PA1-987 was used in Western Blotting to demonstrate the positive effects of iTBS at both motor and behavioral levels.
Thu Jun 01 00:00:00 UTC 2023
Therapeutic role of adipose-derived mesenchymal stem cells-derived extracellular vesicles in rats with obstructive sleep apnea hypopnea syndrome.
Regenerative therapy
Xu L,Zhang L,Xiang Y,Zhang X
PA1-987 was used in Western Blotting to find that ADSCs-EVs transferred miR-22-3p to pneumonocytes and reduced apoptosis, inflammation, and oxidative stress through KDM6B/HMGA2, mitigating OSAHS-LI progression.
Wed Mar 01 00:00:00 UTC 2023
Inactivation of TRPM7 Kinase Targets AKT Signaling and Cyclooxygenase-2 Expression in Human CML Cells.
Function (Oxford, England)
Hoeger B,Nadolni W,Hampe S,Hoelting K,Fraticelli M,Zaborsky N,Madlmayr A,Sperrer V,Fraticelli L,Addington L,Steinritz D,Chubanov V,Geisberger R,Greil R,Breit A,Boekhoff I,Gudermann T,Zierler S
PA1-987 was used in Western Blot to highlight a role of TRPM7 kinase in AKT-driven COX-2 expression and suggest a beneficial potential of TRPM7 blockade in COX-2-related inflammation and malignancy.
Wed Nov 01 00:00:00 UTC 2023
Environmental Enrichment Promotes Transgenerational Programming of Uterine Inflammatory and Stress Markers Comparable to Gestational Chronic Variable Stress.
International journal of molecular sciences
Lopes NA,Ambeskovic M,King SE,Faraji J,Soltanpour N,Falkenberg EA,Scheidl T,Patel M,Fang X,Metz GAS,Olson DM
PA1-987 was used in Western Blotting to find that CVS is transmitted across generations and induces inflammatory changes in the uterus.
Mon Feb 13 00:00:00 UTC 2023
Neuropilin-1, a myeloid cell-specific protein, is an inhibitor of HIV-1 infectivity.
Proceedings of the National Academy of Sciences of the United States of America
Wang S,Zhao L,Zhang X,Zhang J,Shang H,Liang G
Published figure using GAPDH polyclonal antibody (Product # PA1-987) in Western Blot
Tue Jan 11 00:00:00 UTC 2022
RIP3 Contributes to Cardiac Hypertrophy by Influencing MLKL-Mediated Calcium Influx.
Oxidative medicine and cellular longevity
Xue H,Shi H,Zhang F,Li H,Li C,Han Q
Published figure using GAPDH polyclonal antibody (Product # PA1-987) in Western Blot
Tue Apr 26 00:00:00 UTC 2022
Time-limited alterations in cortical activity of a knock-in mouse model of KCNQ2-related developmental and epileptic encephalopathy.
The Journal of physiology
Biba-Maazou N,Becq H,Pallesi-Pocachard E,Sarno S,Granjeaud S,Montheil A,Kurz M,Villard L,Milh M,Santini PL,Aniksztejn L
PA1-987 was used in Western Blotting to study in vivo, using local field potential recordings of freely moving animals, and ex vivo in layers II/III and V of motor cortical slices gain a better understanding of the cellular mechanisms underlying network dysfunction and their progression over time.
Sun May 01 00:00:00 UTC 2022
Time-limited alterations in cortical activity of a knock-in mouse model of KCNQ2-related developmental and epileptic encephalopathy.
The Journal of physiology
Biba-Maazou N,Becq H,Pallesi-Pocachard E,Sarno S,Granjeaud S,Montheil A,Kurz M,Villard L,Milh M,Santini PL,Aniksztejn L
PA1-987 was used in Western Blotting to study in vivo, using local field potential recordings of freely moving animals, and ex vivo in layers II/III and V of motor cortical slices gain a better understanding of the cellular mechanisms underlying network dysfunction and their progression over time.
Sun May 01 00:00:00 UTC 2022
C/D box snoRNA SNORD113-6/AF357425 plays a dual role in integrin signalling and arterial fibroblast function via pre-mRNA processing and 2'O-ribose methylation.
Human molecular genetics
van Ingen E,van den Homberg DAL,van der Bent ML,Mei H,Papac-Milicevic N,Kremer V,Boon RA,Quax PHA,Wojta J,Nossent AY
Published figure using GAPDH polyclonal antibody (Product # PA1-987) in Western Blot
Thu Mar 31 00:00:00 UTC 2022
c-Jun-mediated miR-19b expression induces endothelial barrier dysfunction in an in vitro model of hemorrhagic shock.
Molecular medicine (Cambridge, Mass.)
Wu F,Wang JY,Dorman B,Zeineddin A,Kozar RA
PA1-987 was used in Western Blotting to identify a novel cellular mechanism whereby hypoxia/ reoxygenation increases miR-19b transcription by inducing c-Jun and leads to syndecan-1 decrease and endothelial cell barrier dysfunction.
Wed Oct 12 00:00:00 UTC 2022
c-Jun-mediated miR-19b expression induces endothelial barrier dysfunction in an in vitro model of hemorrhagic shock.
Molecular medicine (Cambridge, Mass.)
Wu F,Wang JY,Dorman B,Zeineddin A,Kozar RA
PA1-987 was used in Western Blotting to identify a novel cellular mechanism whereby hypoxia/ reoxygenation increases miR-19b transcription by inducing c-Jun and leads to syndecan-1 decrease and endothelial cell barrier dysfunction.
Wed Oct 12 00:00:00 UTC 2022
Membrane Protein OTOF Is a Type I Interferon-Induced Entry Inhibitor of HIV-1 in Macrophages.
mBio
Ding H,Zhang X,Zhu Z,Wang S,Xiong Y,Shang H,Liang G
Published figure using GAPDH polyclonal antibody (Product # PA1-987) in Western Blot
Tue Aug 30 00:00:00 UTC 2022
Lack of ZNF365 Drives Senescence and Exacerbates Experimental Lung Fibrosis.
Cells
Urista J,Maldonado M,Toscano-Marquez F,Ramírez R,Balderas-Martínez YI,Becerril C,Romero Y,Selman M,Pardo A
PA1-987 was used in Western Blotting to demonstrate upregulation of ZNF365 in IPF and experimental lung fibrosis. Its absence increases lung fibrosis associated with induction of cell senescence.
Tue Sep 13 00:00:00 UTC 2022
Lack of ZNF365 Drives Senescence and Exacerbates Experimental Lung Fibrosis.
Cells
Urista J,Maldonado M,Toscano-Marquez F,Ramírez R,Balderas-Martínez YI,Becerril C,Romero Y,Selman M,Pardo A
PA1-987 was used in Western Blotting to demonstrate upregulation of ZNF365 in IPF and experimental lung fibrosis. Its absence increases lung fibrosis associated with induction of cell senescence.
Tue Sep 13 00:00:00 UTC 2022
Beta-Site Amyloid Precursor Protein-Cleaving Enzyme Inhibition Partly Restores Sevoflurane-Induced Deficits on Synaptic Plasticity and Spine Loss.
International journal of molecular sciences
Wang X,Shi Q,Pradhan AK,Ziegon L,Schlegel M,Rammes G
PA1-987 was used in Western Blot to suggest that sevo partly elevates BACE activity and interferes with synaptic remodeling, whereas iso mildly modulates synaptic changes in the CA1 region of the hippocampus.
Tue Jun 14 00:00:00 UTC 2022
The role of endogenous Smad7 in regulating macrophage phenotype following myocardial infarction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li J,Li R,Tuleta I,Hernandez SC,Humeres C,Hanna A,Chen B,Frangogiannis NG
PA1-987 was used in Western Blotting to suggest a limited role for macrophage Smad7 in regulation of post-infarction inflammation and repair, and demonstrate that the anti-inflammatory effects of TGF-β in macrophages are not restrained by endogenous Smad7 induction.
Fri Jul 01 00:00:00 UTC 2022
The nephroprotective action of Passiflora edulis in streptozotocin-induced diabetes.
Scientific reports
Araújo Galdino O,de Souza Gomes I,Ferreira de Almeida Júnior R,Conceição Ferreira de Carvalho MI,Abreu BJ,Abbott Galvão Ururahy M,Cabral B,Zucolotto Langassner SM,Costa de Souza KS,Augusto de Rezende A
PA1-987 was used in Western Blotting to investigate use of Passiflora edulis extract together with insulin in nephroprotection of diabetes.
Thu Oct 20 00:00:00 UTC 2022
Understanding the Mechanism of Diabetes Mellitus in a LRBA-Deficient Patient.
Biology
Hawari I,Ericsson J,Kabeer BSA,Chaussabel D,Alsulaiti A,Sharari SA,Maccalli C,Khan FA,Hussain K
PA1-987 was used in Western Blotting to show that DM in a LRBA-deficient patient with a stop codon mutation (c.3999 G gt; A) was not mediated through autoimmunity.
Mon Apr 18 00:00:00 UTC 2022
An Orally Bioavailable and Highly Efficacious Inhibitor of CDK9/FLT3 for the Treatment of Acute Myeloid Leukemia.
Cancers
Anshabo AT,Bantie L,Diab S,Lenjisa J,Kebede A,Long Y,Heinemann G,Karanjia J,Noll B,Basnet SKC,Li M,Milne R,Albrecht H,Wang S
PA1-987 was used in Western Blot to demonstrate the potential of CDDD11-8 towards the future development of a novel AML treatment.
Tue Feb 22 00:00:00 UTC 2022
Expression of FMRpolyG in Peripheral Blood Mononuclear Cells of Women with Fragile X Mental Retardation 1 Gene Premutation.
Genes
Nguyen XP,Vilkaite A,Messmer B,Dietrich JE,Hinderhofer K,Schäkel K,Strowitzki T,Rehnitz J
PA1-987 was used in Western Blotting to investigate Fragile X-associated primary ovarian insufficiency (FXPOI), revealing the presence of FMRpolyG aggregates in peripheral blood monocyte cells (PBMCs) and granulosa cells (GCs) of FMR1 premutation (PM) carriers,.
Tue Mar 01 00:00:00 UTC 2022
METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA.
Cell death & disease
Meng L,Lin H,Huang X,Weng J,Peng F,Wu S
PA1-987 was used in Western Blotting to define the role of METTL14-mediated m6A modification in pyroptosis and diabetic cardiomyopathy (DCM) progression.
Mon Jan 10 00:00:00 UTC 2022
Mechanosensitive molecular mechanisms of myocardial fibrosis in living myocardial slices.
ESC heart failure
Nunez-Toldra R,Kirwin T,Ferraro E,Pitoulis FG,Nicastro L,Bardi I,Kit-Anan W,Gorelik J,Simon AR,Terracciano CM
PA1-987 was used in Western Blot to evaluate early cellular, molecular, and functionality changes related to myocardial fibrosis.
Fri Apr 01 00:00:00 UTC 2022
Overexpressing the hydroxycarboxylic acid receptor 1 in mouse brown adipose tissue restores glucose tolerance and insulin sensitivity in diet-induced obese mice.
American journal of physiology. Endocrinology and metabolism
Min HY,Hwang J,Choi Y,Jo YH
PA1-987 was used in Western Blot to promote healthy metabolism.
Thu Sep 01 00:00:00 UTC 2022
Temporal and Sex-Linked Protein Expression Dynamics in a Familial Model of Alzheimer's Disease.
Molecular & cellular proteomics : MCP
Blasco Tavares Pereira Lopes F,Schlatzer D,Wang R,Li X,Feng E,Koyutürk M,Qi X,Chance MR
PA1-987 was used in Western Blotting to show 5XFAD mice exhibit increases in known human AD biomarkers as amyloid-beta peptide, APOE, GFAP, and ITM2B are upregulated across all time points/stages.
Thu Sep 01 00:00:00 UTC 2022
MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner.
Nature communications
Paniagua I,Tayeh Z,Falcone M,Hernández Pérez S,Cerutti A,Jacobs JJL
PA1-987 was used in Antibody array to conclude that MAD2L2 suppresses aberrant nucleolytic processing both at DSBs and stalled replication forks by differentially engaging shieldin and REV1/REV3L, respectively.
Thu Sep 08 00:00:00 UTC 2022
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
Nature
Chu TT,Tu X,Yang K,Wu J,Repa JJ,Yan N
PA1-987 was used in Western Blotting to identify a cGAS- and cGAMP-independent mode of STING activation that affects neuropathology and provides a therapeutic target for the treatment of Niemann-Pick disease type C.
Sun Aug 01 00:00:00 UTC 2021
Aging lens epithelium is susceptible to ferroptosis.
Free radical biology & medicine
Wei Z,Hao C,Huangfu J,Srinivasagan R,Zhang X,Fan X
PA1-987 was used in RT-qPCR to explore the lens epithelial cell's (LEC) susceptibility to ferroptosis after documentation has concluded that aged and cataractous human lenses manifest with increased reactive oxygen species (ROS) formation, elevated lipid peroxidation, and accumulative intracellular redox-active iron, constituting the three hallmarks of ferroptosis during aging and cataractogenesis.
Sat May 01 00:00:00 UTC 2021
Mitotic Activation Around Wound Edges and Epithelialization Repair in UVB-Induced Capsular Cataracts.
Investigative ophthalmology & visual science
Wei Z,Hao C,Srinivasagan R,Wu H,Chen JK,Fan X
PA1-987 was used in Immunohistochemistry-immunofluorescence to demonstrate that normally quiescent lens epithelial cells can be reactivated for epithelialization repair in response to UV-induced damage.
Wed Dec 01 00:00:00 UTC 2021
Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer.
Bioscience reports
Wang Q,Liang J,Hu X,Gu S,Xu Q,Yan J
PA1-987 was used in Western Blotting to evaluate the integrated prognostic value of four early B-cell factors in gastric cancer patients.
Fri Jul 30 00:00:00 UTC 2021
Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages.
Nature communications
Zhao L,Wang S,Xu M,He Y,Zhang X,Xiong Y,Sun H,Ding H,Geng W,Shang H,Liang G
PA1-987 was used in Western Blot to report the mechanisms behind HIV-1 accessory protein, Vpr, enhancement of macrophage infection.
Thu Jun 17 00:00:00 UTC 2021
Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages.
Nature communications
Zhao L,Wang S,Xu M,He Y,Zhang X,Xiong Y,Sun H,Ding H,Geng W,Shang H,Liang G
PA1-987 was used in Western Blot to report the mechanisms behind HIV-1 accessory protein, Vpr, enhancement of macrophage infection.
Thu Jun 17 00:00:00 UTC 2021
Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells.
Cell death & disease
Huangfu J,Hao C,Wei Z,Wormstone IM,Yan H,Fan X
PA1-987 was used in Western Blot to compare FHL124 cells and HeLa cells, spontaneously immortalized epithelial cell lines derived from the human lens and cervical cancer cells, respectively, of their resistance to TNFα-mediated cell death.
Fri Apr 09 00:00:00 UTC 2021
Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells.
Cell death & disease
Huangfu J,Hao C,Wei Z,Wormstone IM,Yan H,Fan X
PA1-987 was used in Western Blot to compare FHL124 cells and HeLa cells, spontaneously immortalized epithelial cell lines derived from the human lens and cervical cancer cells, respectively, of their resistance to TNFα-mediated cell death.
Fri Apr 09 00:00:00 UTC 2021
Small molecule splicing modifiers with systemic HTT-lowering activity.
Nature communications
Bhattacharyya A,Trotta CR,Narasimhan J,Wiedinger KJ,Li W,Effenberger KA,Woll MG,Jani MB,Risher N,Yeh S,Cheng Y,Sydorenko N,Moon YC,Karp GM,Weetall M,Dakka A,Gabbeta V,Naryshkin NA,Graci JD,Tripodi T,Southwell A,Hayden M,Colacino JM,Peltz SW
Published figure using GAPDH polyclonal antibody (Product # PA1-987) in Western Blot
Wed Dec 15 00:00:00 UTC 2021
Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing.
eLife
Thapa D,Valente JS,Barrett B,Smith MJ,Argunhan F,Lee SY,Nikitochkina S,Kodji X,Brain SD
PA1-987 was used in Western Blotting to reveal that cold sensors, essential for this neurovascular pathway, decline as ageing onsets.
Tue Nov 02 00:00:00 UTC 2021
Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing.
eLife
Thapa D,Valente JS,Barrett B,Smith MJ,Argunhan F,Lee SY,Nikitochkina S,Kodji X,Brain SD
PA1-987 was used in Western Blotting to reveal that cold sensors, essential for this neurovascular pathway, decline as ageing onsets.
Tue Nov 02 00:00:00 UTC 2021
Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase.
The Journal of biological chemistry
Peshenko IV,Olshevskaya EV,Dizhoor AM
PA1-987 was used in Western Blot to demonstrate that aberrant activation of the retinal membrane guanylyl cyclase (RetGC) by its calcium-sensor proteins (guanylyl cyclase-activating protein [GCAP]) causes this retinal degeneration and that RD3 protects photoreceptors by preventing such activation.
Fri Oct 01 00:00:00 UTC 2021
Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase.
The Journal of biological chemistry
Peshenko IV,Olshevskaya EV,Dizhoor AM
PA1-987 was used in Western Blot to demonstrate that aberrant activation of the retinal membrane guanylyl cyclase (RetGC) by its calcium-sensor proteins (guanylyl cyclase-activating protein [GCAP]) causes this retinal degeneration and that RD3 protects photoreceptors by preventing such activation.
Fri Oct 01 00:00:00 UTC 2021
Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer.
Journal of nanobiotechnology
Pan X,Qi Y,Du Z,He J,Yao S,Lu W,Ding K,Zhou M
Published figure using GAPDH polyclonal antibody (Product # PA1-987) in Western Blot
Sat Nov 27 00:00:00 UTC 2021
Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue.
Scientific reports
Qu J,Fourman S,Fitzgerald M,Liu M,Nair S,Oses-Prieto J,Burlingame A,Morris JH,Davidson WS,Tso P,Bhargava A
PA1-987 was used in Western Blot to identify a novel cognate receptor for apolipoprotein A4 in adipose tissue.
Thu Jun 24 00:00:00 UTC 2021
Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue.
Scientific reports
Qu J,Fourman S,Fitzgerald M,Liu M,Nair S,Oses-Prieto J,Burlingame A,Morris JH,Davidson WS,Tso P,Bhargava A
PA1-987 was used in Western Blot to identify a novel cognate receptor for apolipoprotein A4 in adipose tissue.
Thu Jun 24 00:00:00 UTC 2021
Sea-Buckthorn Seed Oil Induces Proliferation of both Normal and Dysplastic Keratinocytes in Basal Conditions and under UVA Irradiation.
Journal of personalized medicine
Dudau M,Vilceanu AC,Codrici E,Mihai S,Popescu ID,Albulescu L,Tarcomnicu I,Moise G,Ceafalan LC,Hinescu ME,Enciu AM,Tanase C
PA1-987 was used in Western Blotting to show that sea-buckthorn seed oil stimulated the proliferation of dysplastic cells, while it also impaired the ability of both normal and dysplastic cells to migrate over a denuded area.
Wed Apr 07 00:00:00 UTC 2021
Mitochondrial Dysfunction and Alterations in Mitochondrial Permeability Transition Pore (mPTP) Contribute to Apoptosis Resistance in Idiopathic Pulmonary Fibrosis Fibroblasts.
International journal of molecular sciences
Luis-García ER,Becerril C,Salgado-Aguayo A,Aparicio-Trejo OE,Romero Y,Flores-Soto E,Mendoza-Milla C,Montaño M,Chagoya V,Pedraza-Chaverri J,El Hafidi M,Orozco-Ibarra M,Pardo A,Selman M
PA1-987 was used in Western Blotting to demonstrate that IPF fibroblasts are resistant to mitomycin C-induced apoptosis and that altered mPTP opening contributes to this resistance.
Fri Jul 23 00:00:00 UTC 2021
Depletion of Retinal Dopaminergic Activity in a Mouse Model of Rod Dysfunction Exacerbates Experimental Autoimmune Uveoretinitis: A Role for the Gateway Reflex.
International journal of molecular sciences
Stofkova A,Zloh M,Andreanska D,Fiserova I,Kubovciak J,Hejda J,Kutilek P,Murakami M
PA1-987 was used in Western Blotting to hypothesize that rod photoreceptor dysfunction causes remodeling of retinal neural activity, which influences the blood-retinal barrier and the development of retinal inflammation.
Fri Dec 31 00:00:00 UTC 2021
Dopamine transporter function fluctuates across sleep/wake state: potential impact for addiction.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Alonso IP,Pino JA,Kortagere S,Torres GE,España RA
PA1-987 was used in Western Blotting to suggest that sleep/wake state influences DA neurotransmission in a manner that is likely to impact a host of DA-dependent processes including a variety of neuropsychiatric disorders.
Mon Mar 01 00:00:00 UTC 2021
Bag-1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience.
Journal of neurochemistry
Luo S,Hou Y,Zhang Y,Feng L,Hunter RG,Yuan P,Jia Y,Li H,Wang G,K Manji H,S McEwen B,Xiao C,Bao H,Du J
PA1-987 was used in Western Blotting to suggest that Bag-1 mediates GR trafficking to mitochondria and regulates affective resilience in response to a CORT increase and provide potential insight into the mechanisms by which Bag-1 and GR could contribute to the physiology and pathogenesis of psychiatric disorders in response to the change of stress hormone.
Thu Jul 01 00:00:00 UTC 2021
EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses.
Pharmaceuticals (Basel, Switzerland)
Ravindran Menon D,Li Y,Yamauchi T,Osborne DG,Vaddi PK,Wempe MF,Zhai Z,Fujita M
PA1-987 was used in Western Blotting to demonstrate that EGCG enhances anti-tumor immune responses by inhibiting JAK-STAT signaling in melanoma.
Tue Oct 26 00:00:00 UTC 2021
Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40.
American journal of physiology. Endocrinology and metabolism
Zhang L,Chen Z,Wang Y,Tweardy DJ,Mitch WE
PA1-987 was used in Western Blot to conclude that Stat3 activation in muscle increases IR in mice.
Fri May 01 00:00:00 UTC 2020
Tau Oligomers and Fibrils Exhibit Differential Patterns of Seeding and Association With RNA Binding Proteins.
Frontiers in neurology
Jiang L,Zhao J,Cheng JX,Wolozin B
PA1-987 was used in Western Blotting to explore the actions of two distinct types of tau aggregates, tau oligomers and tau fibrils in primary neuron cultures expressing human 4R0N tau.
Fri Jun 04 00:00:00 UTC 2021
Skeletal Muscle Anti-Atrophic Effects of Leucine Involve Myostatin Inhibition.
DNA and cell biology
Cruz A,Ferian A,Alves PKN,Silva WJ,Bento MR,Gasch A,Labeit S,Moriscot AS
PA1-987 was used in Western Blotting to study the impact of leucine supplementation on myostatin expression using male rats.
Mon Nov 02 00:00:00 UTC 2020
S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.
PloS one
Wu W,Sung CC,Yu P,Li J,Chung KKK
PA1-987 was used in Western Blotting to demonstrate that GRK6 and CK2α can be S-nitrosylated by nitric oxide (NO) both in vitro and in vivo.
Mon Jul 20 00:00:00 UTC 2020
S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.
PloS one
Wu W,Sung CC,Yu P,Li J,Chung KKK
PA1-987 was used in Western Blotting to demonstrate that GRK6 and CK2α can be S-nitrosylated by nitric oxide (NO) both in vitro and in vivo.
Mon Jul 20 00:00:00 UTC 2020
miR-19b targets pulmonary endothelial syndecan-1 following hemorrhagic shock.
Scientific reports
Wu F,Wang JY,Chao W,Sims C,Kozar RA
PA1-987 was used in Western Blotting to demonstrate that miR-19b targets syndecan-1 mRNA to downregulate its expression.
Fri Sep 25 00:00:00 UTC 2020
miR-19b targets pulmonary endothelial syndecan-1 following hemorrhagic shock.
Scientific reports
Wu F,Wang JY,Chao W,Sims C,Kozar RA
PA1-987 was used in Western Blotting to demonstrate that miR-19b targets syndecan-1 mRNA to downregulate its expression.
Fri Sep 25 00:00:00 UTC 2020
RNA Sequence Analyses throughout the Course of Mouse Cardiac Laminopathy Identify Differentially Expressed Genes for Cell Cycle Control and Mitochondrial Function.
Scientific reports
Shao Z,Koh W,Ni Y,Li W,Agatisa-Boyle B,Merkurjev D,Tang WHW
PA1-987 was used in Western Blotting to demonstrate that impaired oxidative phosphorylation takes place at the early disease stage and worsens with disease progression in familial dilated cardiomyopathy.
Mon Apr 20 00:00:00 UTC 2020
Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma.
Cancers
Zhai Z,Samson JM,Yamauchi T,Vaddi PK,Matsumoto Y,Dinarello CA,Ravindran Menon D,Fujita M
PA1-987 was used in Western Blotting to investigate the role of inflammasome sensor NLRP1 in acquired drug resistance to temozolomide (TMZ) in melanoma.
Fri Sep 04 00:00:00 UTC 2020
Serum Exosomal Proteins F9 and TSP-1 as Potential Diagnostic Biomarkers for Newly Diagnosed Epilepsy.
Frontiers in neuroscience
Lin Z,Gu Y,Zhou R,Wang M,Guo Y,Chen Y,Ma J,Xiao F,Wang X,Tian X
PA1-987 was used in Western Blotting to investigate the use of exosomal proteins as biomarkers for epilepsy.
Mon Sep 28 00:00:00 UTC 2020
lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma.
International journal of oncology
Chen F,Qi S,Zhang X,Wu J,Yang X,Wang R
PA1-987 was used in Western Blotting to investigate the regulatory model of the long noncoding RNA placenta-specific protein 2 upregulation in oral squamous cell carcinoma, and its function in OSCC malignant progression.
Mon Apr 01 00:00:00 UTC 2019
lncRNA ZEB1-AS1 promotes migration and metastasis of bladder cancer cells by post-transcriptional activation of ZEB1.
International journal of molecular medicine
Zhao X,Wang D,Ding Y,Zhou J,Liu G,Ji Z
PA1-987 was used in Western Blotting to determine the role of zinc finger E-box binding homeobox 1-antisense in bladder cancer progression and metastasis.
Mon Jul 01 00:00:00 UTC 2019
miRNA‑183‑5p.1 promotes the migration and invasion of gastric cancer AGS cells by targeting TPM1.
Oncology reports
Lin J,Shen J,Yue H,Cao Z
PA1-987 was used in Western Blotting to identify that the downregulation of TPM1 and deactivation of the Bcl-2/P53 signaling pathways by miR-183-5p.1, promotes proliferation, migration and invasion in gastric cancer.
Sun Dec 01 00:00:00 UTC 2019
Increased expression of FAK isoforms as potential cancer biomarkers in ovarian cancer.
Oncology letters
Nolasco-Quiroga M,Rosas-Díaz M,Moreno J,Godínez-Aguilar R,López-Ibarra MJ,Piña-Sánchez P,Alvarado-Cabrero I,Vázquez-Gómez G,Rocha-Zavaleta L,Arenas-Aranda D,Salamanca-Gómez F
PA1-987 was used in Western Blotting to analyse the expression level of focal adhesion kinase isoforms in ovarian cancer.
Sat Jun 01 00:00:00 UTC 2019
Staphylococcus aureus Exploits the Host Apoptotic Pathway To Persist during Infection.
mBio
Winstel V,Schneewind O,Missiakas D
Published figure using GAPDH polyclonal antibody (Product # PA1-987) in Western Blot
Tue Nov 12 00:00:00 UTC 2019
Identification of Novel Inhibitors of DLK Palmitoylation and Signaling by High Content Screening.
Scientific reports
Martin DDO,Kanuparthi PS,Holland SM,Sanders SS,Jeong HK,Einarson MB,Jacobson MA,Thomas GM
PA1-987 was used in Western Blotting to report that DLK subcellular localization in non-neuronal cells is highly palmitoylation-dependent and can thus serve as a proxy readout to identify inhibitors of DLK palmitoylation by High Content Screening.
Wed Mar 06 00:00:00 UTC 2019
Enantioselective Synthesis of 8-Hydroxyquinoline Derivative, Q134 as a Hypoxic Adaptation Inducing Agent.
Molecules (Basel, Switzerland)
Hackler L,Gyuris M,Huzián O,Alföldi R,Szebeni GJ,Madácsi R,Knapp L,Kanizsai I,Puskás LG
PA1-987 was used in Western Blotting to show that the enantiomers of Q134 showed potent and similar activity in all tested assays.
Sat Nov 23 00:00:00 UTC 2019
Understanding the mechanism of Chikungunya virus vector competence in three species of mosquitoes.
Medical and veterinary entomology
Ghosh A,Mullapudi T,Bomanna S,Tyagi BK,Ravi V,Desai A
PA1-987 was used in Western Blotting to investigate vector competence for CHIKV in Aedes aegypti and Aedes albopictus mosquitoes found in Madurai, South India.
Sun Sep 01 00:00:00 UTC 2019
Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer.
Molecular cancer
Dong H,Hu J,Zou K,Ye M,Chen Y,Wu C,Chen X,Han M
PA1-987 was used in Western Blotting to identify the regulatory role of long non-coding RNA in trastuzumab resistance and accompanied Epithelial-mesenchymal Transition process in advanced human epidermal growth factor receptor 2-positive breast cancer.
Tue Jan 08 00:00:00 UTC 2019
CENP-A Ubiquitylation Is Indispensable to Cell Viability.
Developmental cell
Niikura Y,Kitagawa R,Fang L,Kitagawa K
PA1-987 was used in Control to show that the Flag-tagged or untagged CENP-A K124R mutant is lethal.
Mon Sep 23 00:00:00 UTC 2019
lncRNA ZEB1-AS1 Mediates Oxidative Low-Density Lipoprotein-Mediated Endothelial Cells Injury by Post-transcriptional Stabilization of NOD2.
Frontiers in pharmacology
Xu X,Ma C,Duan Z,Du Y,Liu C
PA1-987 was used in Western Blotting to analyse a poorly characterised human long non-coding RNA, ZEB1 antisense 1.
Thu Oct 01 00:00:00 UTC 2020
Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines.
Virulence
Liu J,Ma'ayeh S,Peirasmaki D,Lundström-Stadelmann B,Hellman L,Svärd SG
Published figure using GAPDH polyclonal antibody (Product # PA1-987) in Western Blot
Mon Dec 31 00:00:00 UTC 2018
Rapid estrogen receptor-α signaling mediated by ERK activation regulates vascular tone in male and ovary-intact female mice.
American journal of physiology. Heart and circulatory physiology
Kim SC,Boese AC,Moore MH,Cleland RM,Chang L,Delafontaine P,Yin KJ,Lee JP,Hamblin MH
Published figure using GAPDH polyclonal antibody (Product # PA1-987) in Western Blot
Thu Feb 01 00:00:00 UTC 2018
Exploration of the regulation and control mechanisms of miR-145 in trophoblast cell proliferation and invasion.
Experimental and therapeutic medicine
Chi Z,Zhang M
PA1-987 was used in Western Blotting to investigate the functions of miR-145 in preeclampsia.
Sat Dec 01 00:00:00 UTC 2018
Transgenic overexpression of furin increases epileptic susceptibility.
Cell death & disease
Yang Y,He M,Tian X,Guo Y,Liu F,Li Y,Zhang H,Lu X,Xu D,Zhou R,Ma Y,Wang W,Chen G,Hu Y,Wang X
PA1-987 was used in Western Blotting to study the role of furin expression in epilepsy.
Wed Oct 17 00:00:00 UTC 2018
Metabolomics reveals critical adrenergic regulatory checkpoints in glycolysis and pentose-phosphate pathways in embryonic heart.
The Journal of biological chemistry
Peoples JNR,Maxmillian T,Le Q,Nadtochiy SM,Brookes PS,Porter GA,Davidson VL,Ebert SN
PA1-987 was used in Western Blotting to study the effects of adrenergic hormones on metabolism in the embryonic heart.
Fri May 04 00:00:00 UTC 2018
Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure.
Cancer cell
Guler GD,Tindell CA,Pitti R,Wilson C,Nichols K,KaiWai Cheung T,Kim HJ,Wongchenko M,Yan Y,Haley B,Cuellar T,Webster J,Alag N,Hegde G,Jackson E,Nance TL,Giresi PG,Chen KB,Liu J,Jhunjhunwala S,Settleman J,Stephan JP,Arnott D,Classon M
PA1-987 was used in Western Blotting to show that the genomes of a cancer cell subpopulation that survives treatment with otherwise lethal drugs, the drug-tolerant persisters, exhibit a repressed chromatin state.
Mon Aug 14 00:00:00 UTC 2017
Impact of R264C and R264H polymorphisms in human aromatase function.
The Journal of steroid biochemistry and molecular biology
Baravalle R,Di Nardo G,Bandino A,Barone I,Catalano S,Andò S,Gilardi G
PA1987 was used in western blot to characterize cytochrome P450 aromatase mutations
Wed Mar 01 00:00:00 UTC 2017
Chlorogenic acid prevents inflammatory responses in IL‑1β‑stimulated human SW‑1353 chondrocytes, a model for osteoarthritis.
Molecular medicine reports
Liu CC,Zhang Y,Dai BL,Ma YJ,Zhang Q,Wang Y,Yang H
PA1-987 was used in Western Blotting to investigate the effects and underlying mechanism of chlorogenic acid on IL-1Β-induced osteoarthritis chondrocytes.
Tue Aug 01 00:00:00 UTC 2017
CRISPR-Cas9-enabled genetic disruptions for understanding ethanol and ethyl acetate biosynthesis in Kluyveromyces marxianus.
Biotechnology for biofuels
Löbs AK,Engel R,Schwartz C,Flores A,Wheeldon I
Published figure using GAPDH polyclonal antibody (Product # PA1-987) in Western Blot
Thu Jan 04 00:00:00 UTC 2024
Human eIF3b and eIF3a serve as the nucleation core for the assembly of eIF3 into two interconnected modules: the yeast-like core and the octamer.
Nucleic acids research
Wagner S,Herrmannová A,Šikrová D,Valášek LS
Published figure using GAPDH polyclonal antibody (Product # PA1-987) in Western Blot
Thu Dec 15 00:00:00 UTC 2016
The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator.
British journal of pharmacology
Hyrsova L,Smutny T,Carazo A,Moravcik S,Mandikova J,Trejtnar F,Gerbal-Chaloin S,Pavek P
PA1-987 was used in western blot to study down-regulation of organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator by the pregane X receptor
Sun May 01 00:00:00 UTC 2016
Uterotonic Neuromedin U Receptor 2 and Its Ligands Are Upregulated by Inflammation in Mice and Humans, and Elicit Preterm Birth.
Biology of reproduction
Nadeau-Vallée M,Boudreault A,Leimert K,Hou X,Obari D,Madaan A,Rouget R,Zhu T,Belarbi L,Brien MÈ,Beaudry-Richard A,Olson DM,Girard S,Chemtob S
PA1987 was used in western blot to measure the expression and function of neuromedin U receptor 2 and its ligands in gestational tissues
Thu Sep 01 00:00:00 UTC 2016
Curcumin eluting nanofibers augment osteogenesis toward phytochemical based bone tissue engineering.
Biomedical materials (Bristol, England)
Jain S,Krishna Meka SR,Chatterjee K
PA1987 was used in western blot to create curcumin-eluting tissue scaffolds and explore their potential in bone tissue regeneration
Thu Oct 06 00:00:00 UTC 2016
An animal model for chorioamnionitis at term.
American journal of obstetrics and gynecology
Dell'Ovo V,Rosenzweig J,Burd I,Merabova N,Darbinian N,Goetzl L
PA1-987 was used in western blot to develop an animal model for intrapartum inflammation at term.
Tue Sep 01 00:00:00 UTC 2015
DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly.
Developmental biology
Ajima R,Bisson JA,Helt JC,Nakaya MA,Habas R,Tessarollo L,He X,Morrisey EE,Yamaguchi TP,Cohen ED
PA1-987 was used in Western Blotting to investigate the Wnt-associated pathways induced by DAAM1 and DAAM2 in the myocardium.
Tue Dec 01 00:00:00 UTC 2015
Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT.
Developmental biology
Bisson JA,Mills B,Paul Helt JC,Zwaka TP,Cohen ED
PA1-987 was used in western blot to study the regulation of the canonical Wnt pathway and its effect on cardiac progenitor development
Sun Feb 01 00:00:00 UTC 2015
Intestinal fatty acid binding protein (fabp2) in Atlantic salmon (Salmo salar): Localization and alteration of expression during development of diet induced enteritis.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
Venold FF,Penn MH,Thorsen J,Gu J,Kortner TM,Krogdahl A,Bakke AM
PA1-987 was used in western blot to study the expression of intestinal fatty acid binding proteins FABP2a1, FABP2a2 and FABPb during diet-induced enteritis in Atlantic salmon
Tue Jan 01 00:00:00 UTC 2013
An antibody-drug conjugate targeting the endothelin B receptor for the treatment of melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Asundi J,Reed C,Arca J,McCutcheon K,Ferrando R,Clark S,Luis E,Tien J,Firestein R,Polakis P
PA1-987 was used in western blot to evaluate an antibody-drug conjugate for melanoma treatment
Tue Mar 01 00:00:00 UTC 2011
Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure.
The Journal of physiology
Briston SJ,Caldwell JL,Horn MA,Clarke JD,Richards MA,Greensmith DJ,Graham HK,Hall MC,Eisner DA,Dibb KM,Trafford AW
PA1-987 was used in western blot to study the mechanism for the dysfunctional excitation-contraction coupling in heart failure
Tue Mar 15 00:00:00 UTC 2011
