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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • GAPVD1 Antibodies

          Invitrogen

          GAPVD1 Polyclonal Antibody

          View all (7) GAPVD1 antibodies
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          Datasheet
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          Cite GAPVD1 Polyclonal Antibody

          • Antibody Testing Data (2)
          GAPVD1 Antibody in Immunocytochemistry (ICC/IF)
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          GAPVD1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          GAPVD1 Antibody (PA5-56123) in ICC/IF

          Immunofluorecent analysis of GAPVD1 in human cell line U-2 OS using GAPVD1 Polyclonal Antibody (Product # PA5-56123). Staining shows localization to cytosol. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          GAPVD1 Antibody in Immunocytochemistry (ICC/IF)
          GAPVD1 Antibody in Immunohistochemistry (IHC)

          Product Details

          PA5-56123

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          0.04-0.4 µg/mL
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -

          Immunocytochemistry (ICC/IF)

          0.25-2 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant protein corresponding to Human GAPVD1. Recombinant protein control fragment (Product #RP-93045).
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.05 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.2, with 40% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2641865

          Product Specific Information

          Immunogen sequence: SSLDLEGESV SELGAGPSGS NGVEALQLLE HEQATTQDNL DDKLRKFEIR DMMGLTDDRD ISETVSETWS TDVLGSDFDP NIDEDRLQEI AGAAAENMLG SLLCLPGSGS VLL

          Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

          Target Information

          GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: DKFZP434C212; GAPex-5; GTPase activating protein and VPS9 domains 1; GTPase-activating protein and VPS9 domain-containing protein 1; MGC138847; MGC138848; Rab5-activating protein 6

          View more View less

          Gene Aliases: 2010005B09Rik; 4432404J10Rik; AW108497; GAPex-5; GAPEX5; GAPVD1; KIAA1521; mKIAA1521; RAP6; RGD1307479; RME-6

          View more View less

          UniProt ID: (Human) Q14C86, (Mouse) Q6PAR5

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          Entrez Gene ID: (Human) 26130, (Mouse) 66691, (Rat) 311880

          View more View less

          Function(s)
          guanyl-nucleotide exchange factor activity GTPase activator activity GTPase activating protein binding cadherin binding involved in cell-cell adhesion protein binding
          Process(es)
          endocytosis signal transduction regulation of GTPase activity positive regulation of GTPase activity regulation of protein transport cell-cell adhesion
          It has to be done as per old AB suggested Products section.
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          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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