Abnova

GATA1 Polyclonal Antibody, MaxPab™

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

H00002623-B01P

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

10-100 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GATA1 (NP_002040, 1 a.a. approximately 413 a.a) full-length human protein.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

Product may be used with Western Blot (Transfected lysate).

The Isotype of this product is composed of an IgG Mixture.

Immunogen sequence: MEFPGLGSLG TSEPLPQFVD PALVSSTPES GVFFPSGPEG LDAAASSTAP STATAAAAAL AYYRDAEAYR HSPVFQVYPL LNCMEGIPGG SPYAGWAYGK TGLYPASTVC PTREDSPPQA VEDLDGKGST SFLETLKTER LSPDLLTLGP ALPSSLPVPN SAYGGPDFSS TFFSPTGSPL NSAAYSSPKL RGTLPLPPCE ARECVNCGAT ATPLWRRDRT GHYLCNACGL YHKMNGQNRP LIRPKKRLIV SKRAGTQCTN CQTTTTTLWR RNASGDPVCN ACGLYYKLHQ VNRPLTMRKD GIQTRNRKAS GKGKKKRGSS LGGTGAAEGP AGGFMVVAGG SGSGNCGEVA SGLTLGPPGT AHLYQGLGPV VLSGPVSHLM PFPGPLLGSP TGSFPTGPMP PTTSTTVVAP LSS

Target Information

Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Eryf1; Erythroid transcription factor; erythroid transcription factor 1; GATA binding protein 1 (globin transcription factor 1); GATA-1; GATA-binding factor 1; globin transcription factor 1; HGNC:4170; NF-E1 DNA-binding protein; nuclear factor, erythroid 1; transcription factor GATA1

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Gene Aliases: ERYF1; GATA-1; GATA1; GF-1; GF1; NF-E1; NFE1; XLANP; XLTDA; XLTT

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UniProt ID: (Human) P15976

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Entrez Gene ID: (Human) 2623

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding DNA binding, bending chromatin DNA binding sequence-specific DNA binding C2H2 zinc finger domain binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development transcription from RNA polymerase II promoter cell-cell signaling heart development blood coagulation negative regulation of cell proliferation male gonad development organ morphogenesis tissue development regulation of glycoprotein biosynthetic process regulation of definitive erythrocyte differentiation regulation of primitive erythrocyte differentiation erythrocyte differentiation megakaryocyte differentiation platelet formation basophil differentiation eosinophil differentiation negative regulation of bone mineralization positive regulation of osteoblast proliferation embryonic hemopoiesis eosinophil fate commitment negative regulation of apoptotic process positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter digestive tract development erythrocyte development homeostasis of number of cells within a tissue positive regulation of peptidyl-tyrosine phosphorylation platelet aggregation transcriptional activation by promoter-enhancer looping dendritic cell differentiation cellular response to thyroid hormone stimulus negative regulation of transcription regulatory region DNA binding negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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