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Product Details
PA5-31236
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human GBP5. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.66 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2548710
Product Specific Information
Recommended positive controls: HeLa.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The guanylate-binding proteins (GBPs) are a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN). GBP5 promotes selective NALP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GBP-5; GBP-TA antigen; GTP-binding protein 5; Guanine nucleotide-binding protein 5; Guanylate-binding protein 5
Gene Aliases: GBP-5; GBP5; UNQ2427/PRO4987
UniProt ID: (Human) Q96PP8
Entrez Gene ID: (Human) 115362
inflammatory response
positive regulation of innate immune response
interleukin-1 beta secretion
protein homotetramerization
cellular response to interferon-gamma
interleukin-18 secretion
positive regulation of cytokine production involved in inflammatory response
positive regulation of NLRP3 inflammasome complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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