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Product Details
PA5-34541
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid peptide near the carboxy terminus of human GBP5
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551893
Product Specific Information
A suggested positive control is rat liver tissue lysate.
PA5-34541 can be used with blocking peptide PEP-1584.
Target Information
The guanylate-binding proteins (GBPs) are a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN). GBP5 promotes selective NALP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GBP-5; GBP-TA antigen; GTP-binding protein 5; Guanine nucleotide-binding protein 5; guanylate nucleotide binding protein 5; Guanylate-binding protein 5; muGBP-5
Gene Aliases: 5330409J06Rik; GBP-5; GBP5; Gbp5a; UNQ2427/PRO4987
UniProt ID: (Human) Q96PP8, (Mouse) Q8CFB4
Entrez Gene ID: (Human) 115362, (Mouse) 229898, (Rat) 362050
inflammatory response
positive regulation of innate immune response
interleukin-1 beta secretion
protein homotetramerization
cellular response to interferon-gamma
interleukin-18 secretion
positive regulation of cytokine production involved in inflammatory response
positive regulation of NLRP3 inflammasome complex assembly
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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