Proteintech

GCDH Polyclonal Antibody

GCDH Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GCDH Antibody (14930-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver tissue slide using 14930-1-AP ( GCDH Antibody) at dilution of 1:200 (under 40x lens).

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Product Details

14930-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GCDH Fusion Protein Ag6713 (85-438 aa encoded by BC002579)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.14 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LANRNEVFH REIISEMGEL GVLGPTIKGY GCAGVSSVAY GLLARELERV DSGYRSAMSV QSSLVMHPIY AYGSEEQRQK YLPQLAKGEL LGCFGLTEPN SGSDPSSMET RAHYNSSNKS YTLNGTKTWI TNSPMADLFV VWARCEDGCI RGFLLEKGMR GLSAPRIQGK FSLRASATGM IIMDGVEVPE ENVLPGASSL GGPFGCLNNA RYGIAWGVLG ASEFCLHTAR QYALDRMQFG VPLARNQLIQ KKLADMLTEI TLGLHACLQL GRLKDQDKAA PEMVSLLKRN NCGKALDIAR QARDMLGGNG ISDEYHVIRH AMNLEAVNTY EGTHDIHALI LGRAITGIQA FTASK (85-438 aa encoded by B C002579)

Target Information

The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Proteomic analysis revealed the pharmacological mechanism of Xueshuantong injection in preventing early acute myocardial infarction injury.

Frontiers in pharmacology

Wang A,Li Y,Wang Z,Xin G,You Y,Sun M,Miao L,Li L,Pan Y,Liu J

Wed Jan 11 00:00:00 UTC 2023

Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.

Molecular metabolism

Hughey CC,James FD,Wang Z,Goelzer M,Wasserman DH

Wed May 01 00:00:00 UTC 2019

Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.

Cancer cell

Tummala KS,Gomes AL,Yilmaz M,Graña O,Bakiri L,Ruppen I,Ximénez-Embún P,Sheshappanavar V,Rodriguez-Justo M,Pisano DG,Wagner EF,Djouder N

Mon Dec 08 00:00:00 UTC 2014

Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.

Cancer cell

Tummala KS,Gomes AL,Yilmaz M,Graña O,Bakiri L,Ruppen I,Ximénez-Embún P,Sheshappanavar V,Rodriguez-Justo M,Pisano DG,Wagner EF,Djouder N

Mon Dec 08 00:00:00 UTC 2014

Effects of targeted suppression of glutaryl-CoA dehydrogenase by lentivirus-mediated shRNA and excessive intake of lysine on apoptosis in rat striatal neurons.

PloS one

Gao J,Zhang C,Fu X,Yi Q,Tian F,Ning Q,Luo X

Wed Dec 04 00:00:00 UTC 2013

Effects of targeted suppression of glutaryl-CoA dehydrogenase by lentivirus-mediated shRNA and excessive intake of lysine on apoptosis in rat striatal neurons.

PloS one

Gao J,Zhang C,Fu X,Yi Q,Tian F,Ning Q,Luo X

Wed Dec 04 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: GCD; Glutaryl-CoA dehydrogenase, mitochondrial; glutaryl-Coenzyme A dehydrogenase

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Gene Aliases: 9030411L18; ACAD5; AI266902; D17825; GCD; GCDH

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UniProt ID: (Human) Q92947, (Mouse) Q60759

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Entrez Gene ID: (Human) 2639, (Mouse) 270076, (Rat) 364975

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Function(s)

fatty-acyl-CoA binding glutaryl-CoA dehydrogenase activity electron carrier activity flavin adenine dinucleotide binding oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor acyl-CoA dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors

Process(es)

acyl-CoA metabolic process metabolic process fatty acid oxidation fatty-acyl-CoA biosynthetic process oxidation-reduction process lysine catabolic process tryptophan metabolic process fatty acid beta-oxidation using acyl-CoA dehydrogenase lipid homeostasis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GCDH Polyclonal Antibody

GCDH Antibody (14930-1-AP) in IHC (P)

Product Details

14930-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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