Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Bioss
GCK/Glucokinase Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
GCK/Glucokinase Antibody (BS-1796R) in WB
Lane 1: mouse brain lysates Lane 2: mouse liver lysates probed with Anti GCK/Glucokinase Polyclonal Antibody, Unconjugated (bs-1796R) at 1:200 in 4C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 90min in 37C. Predicted band 51kD. Observed band size: 51kD.
Product Details
BS-1796R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human GCK, amino acids 101-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: ATP:D-hexose 6-phosphotransferase; GC kinase; Glucokinase; glucokinase (hexokinase 4); glucokinase variant 3; hexokinase 4; hexokinase D, pancreatic isozyme; Hexokinase type IV; Hexokinase-4; Hexokinase-D; HK IV; HK4; MEKKK 2
Gene Aliases: FGQTL3; GCK; GK; GLK; Gls006; GLUKA; HHF3; HK4; HKIV; Hlb62; HXKP; LGLK; MODY2; RNGK2
UniProt ID: (Human) P35557, (Rat) P17712, (Mouse) P52792
Entrez Gene ID: (Human) 2645, (Rat) 24385, (Mouse) 103988
magnesium ion binding
glucokinase activity
protein binding
ATP binding
glucose binding
fructokinase activity
mannokinase activity
protein phosphatase binding
ADP binding
nucleotide binding
hexokinase activity
kinase activity
transferase activity
phosphotransferase activity, alcohol group as acceptor
cellular glucose homeostasis
glycogen biosynthetic process
fructose 2,6-bisphosphate metabolic process
glucose metabolic process
glycolytic process
NADP metabolic process
positive regulation of cytosolic calcium ion concentration
response to glucose
second-messenger-mediated signaling
positive regulation of insulin secretion
negative regulation of epinephrine secretion
cellular response to insulin stimulus
cellular response to glucose starvation
positive regulation of phosphorylation
glucose homeostasis
regulation of potassium ion transport
cellular response to leptin stimulus
negative regulation of gluconeogenesis
positive regulation of glycogen biosynthetic process
positive regulation of glycolytic process
carbohydrate phosphorylation
regulation of insulin secretion
glucose 6-phosphate metabolic process
detection of glucose
lipid homeostasis
calcium ion import
regulation of glycolytic process
regulation of glucose transport
glucose transport
canonical glycolysis
carbohydrate metabolic process
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support