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Invitrogen
GCKR Polyclonal Antibody
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FIGURE: 1 / 1
GCKR Antibody (PA5-109758) in WB
Western blot analysis of GCKR in extracts of various cell lines. Samples were incubated with GCKR Polyclonal antibody (Product # PA5-109758) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-109758
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GCKR (NP_001477.2).
Conjugate
Form
Liquid
Concentration
0.11 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2855169
Product Specific Information
Immunogen sequence: MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV RLLGQCDAEI FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE GTEDSALHGI EELKKVAAGK KRVIVIGISV GLSAPFVAGQ MDCCMNNTAV FLPVLVGFNP VSMARNDPIE DWSSTFRQVA ERMQKMQEKQ KAFVLNPAIG PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGIAASQR CLLEILRTFE
Target Information
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GKRP; Glucokinase regulator; Glucokinase regulatory protein; hexokinase 4
Gene Aliases: FGQTL5; GCKR; GKRP; GLRE
UniProt ID: (Human) Q14397, (Rat) Q07071, (Mouse) Q91X44
Entrez Gene ID: (Human) 2646, (Rat) 25658, (Mouse) 231103
protein import into nucleus, translocation
carbohydrate metabolic process
response to fructose
regulation of glucose transport
negative regulation of glucokinase activity
urate metabolic process
triglyceride homeostasis
cellular glucose homeostasis
glucose metabolic process
positive regulation of glucokinase activity
protein localization to nucleus
negative regulation of catalytic activity
detection of glucose
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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