Product References
α-Cyperone protects dopaminergic neurons and inhibits neuroinflammation in LPS-induced Parkinson's disease rat model via activating Nrf2/HO-1 and suppressing NF-κB signaling pathway.
International immunopharmacology
Huang B,Hu G,Zong X,Yang S,He D,Gao X,Liu D
Wed Feb 01 00:00:00 UTC 2023
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain.
Toxicology mechanisms and methods
Tang S,Zhang H,Xia Y,Luo S,Liu Y,Duan X,Zou Z,Chen C,Zhou L,Qiu J
Wed Feb 01 00:00:00 UTC 2023
Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways.
The Journal of pharmacy and pharmacology
Zhang M,Zhang J,Zhu QM,Zhao WY,Lv X,Yi J,Huo XK,Wang MJ,Sun CP
Wed Feb 08 00:00:00 UTC 2023
CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma.
Journal of endocrinological investigation
Wu N,Zhu D,Li J,Li X,Zhu Z,Rao Q,Hu B,Wang H,Zhu Y
Tue Aug 01 00:00:00 UTC 2023
CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma.
Journal of endocrinological investigation
Wu N,Zhu D,Li J,Li X,Zhu Z,Rao Q,Hu B,Wang H,Zhu Y
Tue Aug 01 00:00:00 UTC 2023
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
EBioMedicine
Wang Y,Tang B,Li H,Zheng J,Zhang C,Yang Z,Tan X,Luo P,Ma L,Wang Y,Long L,Chen Z,Xiao Z,Ma L,Zhou J,Wang Y,Shi C
Sat Apr 01 00:00:00 UTC 2023
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.
ACS central science
Zhang J,Zhang M,Huo XK,Ning J,Yu ZL,Morisseau C,Sun CP,Hammock BD,Ma XC
Wed Mar 22 00:00:00 UTC 2023
Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein-Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis.
Antioxidants (Basel, Switzerland)
Zhang X,Cui K,Wang X,Tong Y,Liu C,Zhu Y,You Q,Jiang Z,Guo X
Mon May 08 00:00:00 UTC 2023
Aescin can alleviate NAFLD through Keap1-Nrf2 by activating antioxidant and autophagy.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Yu H,Yan S,Jin M,Wei Y,Zhao L,Cheng J,Ding L,Feng H
Mon May 01 00:00:00 UTC 2023
Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis.
Toxicology and applied pharmacology
Xu Z,Zhang M,Wang W,Zhou S,Yu M,Qiu X,Jiang S,Wang X,Tang C,Li S,Wang CH,Zhu R,Peng WX,Zhao L,Fu X,Patzak A,Persson PB,Zhao L,Mao J,Shu Q,Lai EY,Zhang G
Tue Aug 15 00:00:00 UTC 2023
IRF5 knockdown reverses TDP-related phenotypes partially by increasing TBK1 expression.
Brain research
Li Y,Yu L,Liu C,Duan W,Zhang S,Li Z,Yi L,Guo M,Bi Y,Li C,Liu Y
Sun Jan 01 00:00:00 UTC 2023
Human hematopoietic stem cell vulnerability to ferroptosis.
Cell
Zhao J,Jia Y,Mahmut D,Deik AA,Jeanfavre S,Clish CB,Sankaran VG
Thu Feb 16 00:00:00 UTC 2023
Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway.
International journal of molecular sciences
Li Z,Gu Z,Wang L,Guan Y,Lyu Y,Zhang J,Wang Y,Wang X,Xiong J,Liu Y
Sat May 27 00:00:00 UTC 2023
Sulforaphane prevents LPS-induced inflammation by regulating the Nrf2-mediated autophagy pathway in goat mammary epithelial cells and a mouse model of mastitis.
Journal of animal science and biotechnology
Shao D,Shen W,Miao Y,Gao Z,Pan M,Wei Q,Yan Z,Zhao X,Ma B
Wed May 03 00:00:00 UTC 2023
Sulforaphane Suppresses H2O2-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells.
International journal of molecular sciences
Shao D,Gao Z,Zhao Y,Fan M,Zhao X,Wei Q,Pan M,Ma B
Thu Jan 05 00:00:00 UTC 2023
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Stem cell research & therapy
Yin BF,Li ZL,Yan ZQ,Guo Z,Liang JW,Wang Q,Zhao ZD,Li PL,Hao RC,Han MY,Li XT,Mao N,Ding L,Chen DF,Gao Y,Zhu H
Tue Jun 07 00:00:00 UTC 2022
Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Zhang J,Zhang M,Zhang WH,Zhu QM,Ning J,Huo XK,Xiao HT,Sun CP
Thu Dec 01 00:00:00 UTC 2022
Cysteine is a limiting factor for glioma proliferation and survival.
Molecular oncology
Ruiz-Rodado V,Dowdy T,Lita A,Kramp T,Zhang M,Jung J,Dios-Esponera A,Zhang L,Herold-Mende CC,Camphausen K,Gilbert MR,Larion M
Sun May 01 00:00:00 UTC 2022
Using Collagen Peptides From the Skin of Monkfish (Lophius litulon) to Ameliorate Kidney Damage in High-Fat Diet Fed Mice by Regulating the Nrf2 Pathway and NLRP3 Signaling.
Frontiers in nutrition
Miao B,Zheng J,Zheng G,Tian X,Zhang W,Yuan F,Yang Z
Mon May 02 00:00:00 UTC 2022
Immunomodulatory actions of a kynurenine-derived endogenous electrophile.
Science advances
Carreño M,Pires MF,Woodcock SR,Brzoska T,Ghosh S,Salvatore SR,Chang F,Khoo NKH,Dunn M,Connors N,Yuan S,Straub AC,Wendell SG,Kato GJ,Freeman BA,Ofori-Acquah SF,Sundd P,Schopfer FJ,Vitturi DA
Fri Jul 01 00:00:00 UTC 2022
Exposure to Heated Tobacco Products Aerosol Causes Acute Stress Responses in the Lung of Mouse.
Antioxidants (Basel, Switzerland)
Koike S,Sato K,Sawa M,Inaba Y,Hattori K,Nakadate K,Ushiyama A,Ogasawara Y
Fri Nov 25 00:00:00 UTC 2022
Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway.
The Journal of pharmacy and pharmacology
Li J,Gao Y,Cui L,He H,Zheng J,Mo S,Zhou X,Chu S,Sun X,Chen N,Wang H
Fri May 20 00:00:00 UTC 2022
The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders.
Phytotherapy research : PTR
Wu XY,Wang T,Hu HX,Zhang K,Zhao Y,Zhao BB,Lou HX,Wang XN,Shen T
Fri Apr 01 00:00:00 UTC 2022
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Journal of ethnopharmacology
Xu LT,Wang T,Fang KL,Zhao Y,Wang XN,Ren DM,Shen T
Sun Jan 30 00:00:00 UTC 2022
PrPSc Inhibition and Cellular Protection of DBL on a Prion-Infected Cultured Cell via Multiple Pathways.
Molecular neurobiology
Yang W,Chen C,Chen J,Xia Y,Hu C,Wang L,Wu YZ,Shi Q,Chen ZB,Dong XP
Sun May 01 00:00:00 UTC 2022
Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice.
Free radical biology & medicine
Han P,Wang X,Zhou T,Cheng J,Wang C,Sun F,Zhao X
Sun Nov 20 00:00:00 UTC 2022
Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis.
Redox biology
Rom O,Liu Y,Finney AC,Ghrayeb A,Zhao Y,Shukha Y,Wang L,Rajanayake KK,Das S,Rashdan NA,Weissman N,Delgadillo L,Wen B,Garcia-Barrio MT,Aviram M,Kevil CG,Yurdagul A,Pattillo CB,Zhang J,Sun D,Hayek T,Gottlieb E,Mor I,Chen YE
Wed Jun 01 00:00:00 UTC 2022
Acute lung inflammation induced by zinc oxide nanoparticles: Evolution and intervention via NRF2 activator.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Guo T,Fang X,Liu Y,Ruan Y,Hu Y,Wang X,Hu Y,Wang G,Xu Y
Fri Apr 01 00:00:00 UTC 2022
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes.
Cell biology and toxicology
Wijaya LS,Rau C,Braun TS,Marangoz S,Spegg V,Vlasveld M,Albrecht W,Brecklinghaus T,Kamp H,Beltman JB,Hengstler JG,van de Water B,Leist M,Schildknecht S
Sat Oct 01 00:00:00 UTC 2022
Action of the Nrf2/ARE signaling pathway on oxidative stress in choroid plexus epithelial cells following lanthanum chloride treatment.
Journal of inorganic biochemistry
Sun J,Zhang Y,Yan L,Liu S,Wang W,Zhu Y,Wang W,Li S,He B,Wu L,Zhang L
Wed Jun 01 00:00:00 UTC 2022
Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.
The Journal of biological chemistry
Jin X,Li X,Li L,Zhong B,Hong Y,Niu J,Li B
Thu Dec 01 00:00:00 UTC 2022
Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein.
Critical care (London, England)
Zhang L,Zhang Y,Qin X,Jiang X,Zhang J,Mao L,Jiang Z,Jiang Y,Liu G,Qiu J,Chen C,Qiu F,Zou Z
Thu Jun 09 00:00:00 UTC 2022
Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Zhang J,Zhang M,Zhang WH,Zhu QM,Huo XK,Sun CP,Ma XC,Xiao HT
Thu Dec 01 00:00:00 UTC 2022
Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway.
Animals : an open access journal from MDPI
Guo S,Yang J,Qin J,Qazi IH,Pan B,Zang S,Lv T,Deng S,Fang Y,Zhou G
Fri Aug 06 00:00:00 UTC 2021
CREB1 and ATF1 Negatively Regulate Glutathione Biosynthesis Sensitizing Cells to Oxidative Stress.
Frontiers in cell and developmental biology
Zhao L,Xia W,Jiang P
Tue Jun 29 00:00:00 UTC 2021
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
International immunopharmacology
Wang L,Wang X,Kong L,Wang S,Huang K,Wu J,Wang C,Sun H,Liu K,Meng Q
Mon Nov 01 00:00:00 UTC 2021
Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress.
The Journal of pharmacology and experimental therapeutics
Martinez R,Huang W,Samadani R,Mackowiak B,Centola G,Chen L,Conlon IL,Hom K,Kane MA,Fletcher S,Shapiro P
Fri Jan 01 00:00:00 UTC 2021
Rutaecarpine Inhibits Doxorubicin-Induced Oxidative Stress and Apoptosis by Activating AKT Signaling Pathway.
Frontiers in cardiovascular medicine
Liao ZQ,Jiang YN,Su ZL,Bi HL,Li JT,Li CL,Yang XL,Zhang Y,Xie X
Tue Jan 25 00:00:00 UTC 2022
Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Bao S,Zheng H,Chen C,Zhang Y,Bao L,Yang B,Hou Y,Chen Y,Zhang Q,Pi J,Fu J
Wed Dec 01 00:00:00 UTC 2021
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
Journal of ethnopharmacology
Sun Y,He L,Wang W,Wang T,Hua W,Li T,Wang L,Gao T,Chen F,Tang L
Thu Mar 25 00:00:00 UTC 2021
Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway.
Oxidative medicine and cellular longevity
Lu Y,Zhang W,Zhang B,Heinemann SH,Hoshi T,Hou S,Zhang G
Thu Jan 06 00:00:00 UTC 2022
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
Molecules (Basel, Switzerland)
Chen J,Chen Y,Zheng Y,Zhao J,Yu H,Zhu J,Li D
Mon May 17 00:00:00 UTC 2021
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Molecules (Basel, Switzerland)
Chen J,Chen Y,Zheng Y,Zhao J,Yu H,Zhu J,Li D
Mon Sep 13 00:00:00 UTC 2021
Lycium barbarum polysaccharides attenuate cardiovascular oxidative stress injury by enhancing the Keap1/Nrf2 signaling pathway in exhaustive exercise rats.
Molecular medicine reports
Hu X,Mu L,Zhu L,Chang X,Nie L,Wang L,Li G
Wed Sep 01 00:00:00 UTC 2021
Lycium barbarum polysaccharides attenuate cardiovascular oxidative stress injury by enhancing the Keap1/Nrf2 signaling pathway in exhaustive exercise rats.
Molecular medicine reports
Hu X,Mu L,Zhu L,Chang X,Nie L,Wang L,Li G
Wed Sep 01 00:00:00 UTC 2021
Lycium barbarum polysaccharides attenuate cardiovascular oxidative stress injury by enhancing the Keap1/Nrf2 signaling pathway in exhaustive exercise rats.
Molecular medicine reports
Hu X,Mu L,Zhu L,Chang X,Nie L,Wang L,Li G
Wed Sep 01 00:00:00 UTC 2021
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Medical science monitor : international medical journal of experimental and clinical research
Pan H,Xu Y,Cai Q,Wu M,Ding M
Fri Jun 04 00:00:00 UTC 2021
RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.
Cell death & disease
Feng X,Jiang T,Yang C,Pang S,Ding Z,Hu H,Wang H,Dong L,Yang N
Fri Dec 17 00:00:00 UTC 2021
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
Food chemistry
Wang Y,Jin R,Chen J,Cao J,Xiao J,Li X,Sun C
Wed Dec 15 00:00:00 UTC 2021
Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.
International immunopharmacology
Zhu Z,Hu R,Li J,Xing X,Chen J,Zhou Q,Sun J
Thu Jul 01 00:00:00 UTC 2021
hPMSCs inhibit the expression of PD-1 in CD4+IL-10+ T cells and mitigate liver damage in a GVHD mouse model by regulating the crosstalk between Nrf2 and NF-κB signaling pathway.
Stem cell research & therapy
Zhang A,Zhang J,Li X,Zhang H,Xiong Y,Wang Z,Zhao N,Wang F,Luan X
Tue Jun 29 00:00:00 UTC 2021
Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor - like 2 and Sirtuin 2 signaling pathways.
Bioengineered
Deng J,Huang M,Wu H
Wed Dec 01 00:00:00 UTC 2021
Blockade of Glutathione Metabolism in IDH1-Mutated Glioma.
Molecular cancer therapeutics
Tang X,Fu X,Liu Y,Yu D,Cai SJ,Yang C
Wed Jan 01 00:00:00 UTC 2020
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Acta biochimica et biophysica Sinica
Chen X,Qi J,Wu Q,Jiang H,Wang J,Chen W,Mao A,Zhu M
Tue May 26 00:00:00 UTC 2020
Protective effect of astaxanthin against La2O3 nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Yuan L,Qu Y,Li Q,An T,Chen Z,Chen Y,Deng X,Bai D
Thu Oct 01 00:00:00 UTC 2020
(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis.
Cell death & disease
Wang M,Liu CY,Wang T,Yu HM,Ouyang SH,Wu YP,Gong HB,Ma XH,Jiao GL,Fu LL,Wu QS,Kurihara H,Li YF,Shen T,He RR
Sat Sep 19 00:00:00 UTC 2020
Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice.
Scientific reports
Tamatam CM,Reddy NM,Potteti HR,Ankireddy A,Noone PM,Yamamoto M,Kensler TW,Reddy SP
Wed Nov 04 00:00:00 UTC 2020
Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes.
International journal of molecular sciences
Wang S,Cheng H,Wang L,Zhao R,Guan D
Mon Mar 16 00:00:00 UTC 2020
Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma.
Cancers
Liu Y,Pang Y,Caisova V,Ding J,Yu D,Zhou Y,Huynh TT,Ghayee H,Pacak K,Yang C
Thu Jan 23 00:00:00 UTC 2020
Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma.
Cancers
Liu Y,Pang Y,Caisova V,Ding J,Yu D,Zhou Y,Huynh TT,Ghayee H,Pacak K,Yang C
Thu Jan 23 00:00:00 UTC 2020
Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma.
Cancers
Liu Y,Pang Y,Caisova V,Ding J,Yu D,Zhou Y,Huynh TT,Ghayee H,Pacak K,Yang C
Thu Jan 23 00:00:00 UTC 2020
Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma.
Cancers
Liu Y,Pang Y,Caisova V,Ding J,Yu D,Zhou Y,Huynh TT,Ghayee H,Pacak K,Yang C
Thu Jan 23 00:00:00 UTC 2020
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Journal of food biochemistry
Wang Z,Cai L,Li H,Liang M,Zhang Y,Wu Q,Yang L
Fri May 01 00:00:00 UTC 2020
A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions.
Redox biology
Lu M,Zhang X,Zhao J,You Q,Jiang Z
Wed Jul 01 00:00:00 UTC 2020
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Oxidative medicine and cellular longevity
Qi J,Chen X,Wu Q,Wang J,Zhang H,Mao A,Zhu M,Miao C
Tue Nov 17 00:00:00 UTC 2020
Neuroprotective effect of dimethyl fumarate on cognitive impairment induced by ischemic stroke.
Annals of translational medicine
Hou X,Xu H,Chen W,Zhang N,Zhao Z,Fang X,Zhang X,Chen H,Xu Y
Sun Mar 01 00:00:00 UTC 2020
Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells.
Biochemical and biophysical research communications
Lee JJ,Ishihara K,Notomi S,Efstathiou NE,Ueta T,Maidana D,Chen X,Iesato Y,Caligiana A,Vavvas DG
Wed Jan 08 00:00:00 UTC 2020
Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection.
Nature communications
Wei Y,Lu M,Mei M,Wang H,Han Z,Chen M,Yao H,Song N,Ding X,Ding J,Xiao M,Hu G
Tue Feb 18 00:00:00 UTC 2020
4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease.
Journal of natural products
Yang WJ,Chen XM,Wang SQ,Hu HX,Cheng XP,Xu LT,Ren DM,Wang XN,Zhao BB,Lou HX,Shen T
Fri Apr 24 00:00:00 UTC 2020
FSHR ablation induces depression-like behaviors.
Acta pharmacologica Sinica
Bi WK,Shao SS,Li ZW,Ruan YW,Luan SS,Dong ZH,Wang J,Wu SS,Guo T,Ma SZ,Gao L,Zhao JJ,He Z
Sat Aug 01 00:00:00 UTC 2020
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Journal of medicinal food
Li H,Liang M,Wang Z,Zhang Y,Wu Q,Yang L
Mon Jun 01 00:00:00 UTC 2020
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Current medical science
Hang H,Wang LK,Ren SY,Song AJ,Wu GF
Sat Feb 01 00:00:00 UTC 2020
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Current medical science
Hang H,Wang LK,Ren SY,Song AJ,Wu GF
Sat Feb 01 00:00:00 UTC 2020
Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury.
Journal of molecular medicine (Berlin, Germany)
Peng L,Zhao Y,Li Y,Zhou Y,Li L,Lei S,Yu S,Zhao Y
Fri Feb 01 00:00:00 UTC 2019
Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury.
Journal of molecular medicine (Berlin, Germany)
Peng L,Zhao Y,Li Y,Zhou Y,Li L,Lei S,Yu S,Zhao Y
Fri Feb 01 00:00:00 UTC 2019
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Journal of the science of food and agriculture
Wang Z,Liang M,Li H,Cai L,He H,Wu Q,Yang L
Thu Aug 15 00:00:00 UTC 2019
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
ACS chemical neuroscience
Yan J,Pang Y,Zhuang J,Lin H,Zhang Q,Han L,Ke P,Zhuang J,Huang X
Wed Jun 19 00:00:00 UTC 2019
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
Journal of ethnopharmacology
Lu Q,Tan S,Gu W,Li F,Hua W,Zhang S,Chen F,Tang L
Mon Oct 28 00:00:00 UTC 2019
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Nature communications
Wang Z,Chen Z,Jiang Z,Luo P,Liu L,Huang Y,Wang H,Wang Y,Long L,Tan X,Liu D,Jin T,Wang Y,Wang Y,Liao F,Zhang C,Chen L,Gan Y,Liu Y,Yang F,Huang C,Miao H,Chen J,Cheng T,Fu X,Shi C
Mon Jun 10 00:00:00 UTC 2019
Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis.
Redox biology
Jobbagy S,Vitturi DA,Salvatore SR,Turell L,Pires MF,Kansanen E,Batthyany C,Lancaster JR,Freeman BA,Schopfer FJ
Fri Feb 01 00:00:00 UTC 2019
Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.
Neurochemical research
Betharia S,Rondόn-Ortiz AN,Brown DA
Thu Aug 01 00:00:00 UTC 2019
SIRT2, ERK and Nrf2 Mediate NAD+ Treatment-Induced Increase in the Antioxidant Capacity of PC12 Cells Under Basal Conditions.
Frontiers in molecular neuroscience
Zhang J,Hong Y,Cao W,Yin S,Shi H,Ying W
Wed Sep 30 00:00:00 UTC 2020
Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.
Chemico-biological interactions
Wu XY,Chen XM,Zhou MX,Hu HX,Zhang JZ,Wang XN,Ren DM,Lou HX,Shen T
Sun Sep 01 00:00:00 UTC 2019
Characterization of natural melanin from Auricularia auricula and its hepatoprotective effect on acute alcohol liver injury in mice.
Food & function
Hou R,Liu X,Yan J,Xiang K,Wu X,Lin W,Chen G,Zheng M,Fu J
Wed Feb 20 00:00:00 UTC 2019
CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation.
Redox biology
Lu MC,Zhao J,Liu YT,Liu T,Tao MM,You QD,Jiang ZY
Sun Sep 01 00:00:00 UTC 2019
Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation.
Marine drugs
Zheng J,Tian X,Zhang W,Zheng P,Huang F,Ding G,Yang Z
Fri Sep 27 00:00:00 UTC 2019
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Food & function
Shu G,Qiu Y,Hao J,Fu Q,Deng X
Wed Oct 16 00:00:00 UTC 2019
An isopentenyl-substituted flavonoid norartocarpin activates Nrf2 signalling pathway and prevents oxidative insults in human lung epithelial cells.
Free radical research
Yang WJ,He JX,Zhou MX,Huang M,Wang SQ,Wang XN,Lou HX,Ren DM,Shen T
Fri Mar 01 00:00:00 UTC 2019
Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors.
Journal of medicinal chemistry
Richardson BG,Jain AD,Potteti HR,Lazzara PR,David BP,Tamatam CR,Choma E,Skowron K,Dye K,Siddiqui Z,Wang YT,Krunic A,Reddy SP,Moore TW
Thu Sep 13 00:00:00 UTC 2018
Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors.
Journal of medicinal chemistry
Richardson BG,Jain AD,Potteti HR,Lazzara PR,David BP,Tamatam CR,Choma E,Skowron K,Dye K,Siddiqui Z,Wang YT,Krunic A,Reddy SP,Moore TW
Thu Sep 13 00:00:00 UTC 2018
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Zheng L,Yin L,Xu L,Qi Y,Li H,Xu Y,Han X,Liu K,Peng J
Mon Jan 01 00:00:00 UTC 2018
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Zheng L,Yin L,Xu L,Qi Y,Li H,Xu Y,Han X,Liu K,Peng J
Mon Jan 01 00:00:00 UTC 2018
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
Oxidative medicine and cellular longevity
Li YR,Li GH,Sun L,Li L,Liu Y,Kong DG,Wang SQ,Ren DM,Wang XN,Lou HX,Shen T
Mon Oct 22 00:00:00 UTC 2018
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
Oxidative medicine and cellular longevity
Li YR,Li GH,Sun L,Li L,Liu Y,Kong DG,Wang SQ,Ren DM,Wang XN,Lou HX,Shen T
Mon Oct 22 00:00:00 UTC 2018
Bioavailable Blueberry-Derived Phenolic Acids at Physiological Concentrations Enhance Nrf2-Regulated Antioxidant Responses in Human Vascular Endothelial Cells.
Molecular nutrition & food research
Tang JS,Vissers MCM,Anderson RF,Sreebhavan S,Bozonet SM,Scheepens A,Melton LD
Thu Mar 01 00:00:00 UTC 2018
Bioavailable Blueberry-Derived Phenolic Acids at Physiological Concentrations Enhance Nrf2-Regulated Antioxidant Responses in Human Vascular Endothelial Cells.
Molecular nutrition & food research
Tang JS,Vissers MCM,Anderson RF,Sreebhavan S,Bozonet SM,Scheepens A,Melton LD
Thu Mar 01 00:00:00 UTC 2018
Progesterone maintains the status of granulosa cells and slows follicle development partly through PGRMC1.
Journal of cellular physiology
Yuan XH,Yang CR,Wang XN,Zhang LL,Gao XR,Shi ZY
Mon Jan 01 00:00:00 UTC 2018
Progesterone maintains the status of granulosa cells and slows follicle development partly through PGRMC1.
Journal of cellular physiology
Yuan XH,Yang CR,Wang XN,Zhang LL,Gao XR,Shi ZY
Mon Jan 01 00:00:00 UTC 2018
3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester induce preconditioning ER stress and autophagy in SH-SY5Y cells.
Journal of cellular physiology
Tomiyama R,Takakura K,Takatou S,Le TM,Nishiuchi T,Nakamura Y,Konishi T,Matsugo S,Hori O
Thu Feb 01 00:00:00 UTC 2018
3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester induce preconditioning ER stress and autophagy in SH-SY5Y cells.
Journal of cellular physiology
Tomiyama R,Takakura K,Takatou S,Le TM,Nishiuchi T,Nakamura Y,Konishi T,Matsugo S,Hori O
Thu Feb 01 00:00:00 UTC 2018
2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone, a potent Nrf2/ARE pathway inhibitor, reverses drug resistance by decreasing glutathione synthesis and drug efflux in BEL-7402/5-FU cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Wei X,Mo X,An F,Ji X,Lu Y
Sat Sep 01 00:00:00 UTC 2018
2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone, a potent Nrf2/ARE pathway inhibitor, reverses drug resistance by decreasing glutathione synthesis and drug efflux in BEL-7402/5-FU cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Wei X,Mo X,An F,Ji X,Lu Y
Sat Sep 01 00:00:00 UTC 2018
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Liang M,Wang Z,Li H,Cai L,Pan J,He H,Wu Q,Tang Y,Ma J,Yang L
Tue May 01 00:00:00 UTC 2018
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Liang M,Wang Z,Li H,Cai L,Pan J,He H,Wu Q,Tang Y,Ma J,Yang L
Tue May 01 00:00:00 UTC 2018
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.
Journal of ethnopharmacology
Yang WJ,Li YR,Gao H,Wu XY,Wang XL,Wang XN,Xiang L,Ren DM,Lou HX,Shen T
Wed Dec 05 00:00:00 UTC 2018
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.
Journal of ethnopharmacology
Yang WJ,Li YR,Gao H,Wu XY,Wang XL,Wang XN,Xiang L,Ren DM,Lou HX,Shen T
Wed Dec 05 00:00:00 UTC 2018
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.
Journal of ethnopharmacology
Yang WJ,Li YR,Gao H,Wu XY,Wang XL,Wang XN,Xiang L,Ren DM,Lou HX,Shen T
Wed Dec 05 00:00:00 UTC 2018
Schwann Cell Plasticity is Regulated by a Weakened Intrinsic Antioxidant Defense System in Acute Peripheral Nerve Injury.
Neuroscience
Lv W,Deng B,Duan W,Li Y,Liu Y,Li Z,Xia W,Li C
Sun Jul 01 00:00:00 UTC 2018
Schwann Cell Plasticity is Regulated by a Weakened Intrinsic Antioxidant Defense System in Acute Peripheral Nerve Injury.
Neuroscience
Lv W,Deng B,Duan W,Li Y,Liu Y,Li Z,Xia W,Li C
Sun Jul 01 00:00:00 UTC 2018
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Regulatory toxicology and pharmacology : RTP
Ning C,Gao X,Wang C,Kong Y,Liu Z,Sun H,Sun P,Huo X,Ma X,Meng Q,Liu K
Mon Oct 01 00:00:00 UTC 2018
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Regulatory toxicology and pharmacology : RTP
Ning C,Gao X,Wang C,Kong Y,Liu Z,Sun H,Sun P,Huo X,Ma X,Meng Q,Liu K
Mon Oct 01 00:00:00 UTC 2018
Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury.
Hepatology (Baltimore, Md.)
Sun Y,Li TY,Song L,Zhang C,Li J,Lin ZZ,Lin SC,Lin SY
Fri Jun 01 00:00:00 UTC 2018
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Environmental toxicology and pharmacology
Zhang W,Yin L,Tao X,Xu L,Zheng L,Han X,Xu Y,Wang C,Peng J
Fri Jul 01 00:00:00 UTC 2016
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Environmental toxicology and pharmacology
Zhang W,Yin L,Tao X,Xu L,Zheng L,Han X,Xu Y,Wang C,Peng J
Fri Jul 01 00:00:00 UTC 2016
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Environmental toxicology and pharmacology
Zhang W,Yin L,Tao X,Xu L,Zheng L,Han X,Xu Y,Wang C,Peng J
Fri Jul 01 00:00:00 UTC 2016
Progesterone amplifies oxidative stress signal and promotes NO production via H2O2 in mouse kidney arterial endothelial cells.
The Journal of steroid biochemistry and molecular biology
Yuan XH,Fan YY,Yang CR,Gao XR,Zhang LL,Hu Y,Wang YQ,Jun H
Fri Jan 01 00:00:00 UTC 2016
Progesterone amplifies oxidative stress signal and promotes NO production via H2O2 in mouse kidney arterial endothelial cells.
The Journal of steroid biochemistry and molecular biology
Yuan XH,Fan YY,Yang CR,Gao XR,Zhang LL,Hu Y,Wang YQ,Jun H
Fri Jan 01 00:00:00 UTC 2016
Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity.
Neurochemistry international
Yu G,Deng A,Tang W,Ma J,Yuan C,Ma J
Wed Jun 01 00:00:00 UTC 2016
Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity.
Neurochemistry international
Yu G,Deng A,Tang W,Ma J,Yuan C,Ma J
Wed Jun 01 00:00:00 UTC 2016
SIRT2 mediates NADH-induced increases in Nrf2, GCL, and glutathione by modulating Akt phosphorylation in PC12 cells.
FEBS letters
Cao W,Hong Y,Chen H,Wu F,Wei X,Ying W
Fri Jul 01 00:00:00 UTC 2016
SIRT2 mediates NADH-induced increases in Nrf2, GCL, and glutathione by modulating Akt phosphorylation in PC12 cells.
FEBS letters
Cao W,Hong Y,Chen H,Wu F,Wei X,Ying W
Fri Jul 01 00:00:00 UTC 2016
Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase.
Free radical research
Nie H,Xue X,Liu G,Guan G,Liu H,Sun L,Zhao L,Wang X,Chen Z
Thu Feb 09 00:00:00 UTC 2017
Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase.
Free radical research
Nie H,Xue X,Liu G,Guan G,Liu H,Sun L,Zhao L,Wang X,Chen Z
Thu Feb 09 00:00:00 UTC 2017
Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer.
Journal of hematology & oncology
Tian Y,Wu K,Liu Q,Han N,Zhang L,Chu Q,Chen Y
Tue Sep 06 00:00:00 UTC 2016
Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer.
Journal of hematology & oncology
Tian Y,Wu K,Liu Q,Han N,Zhang L,Chu Q,Chen Y
Tue Sep 06 00:00:00 UTC 2016
The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.
Scientific reports
Zheng ZG,Xu H,Suo SS,Xu XL,Ni MW,Gu LH,Chen W,Wang LY,Zhao Y,Tian B,Hua YJ
Thu May 19 00:00:00 UTC 2016
The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.
Scientific reports
Zheng ZG,Xu H,Suo SS,Xu XL,Ni MW,Gu LH,Chen W,Wang LY,Zhao Y,Tian B,Hua YJ
Thu May 19 00:00:00 UTC 2016
15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways.
Chemico-biological interactions
Snyder NW,Golin-Bisello F,Gao Y,Blair IA,Freeman BA,Wendell SG
Fri Jun 05 00:00:00 UTC 2015
Estradiol decreases taurine level by reducing cysteine sulfinic acid decarboxylase via the estrogen receptor-α in female mice liver.
American journal of physiology. Gastrointestinal and liver physiology
Ma Q,Zhao J,Cao W,Liu J,Cui S
Sun Feb 15 00:00:00 UTC 2015
Estradiol decreases taurine level by reducing cysteine sulfinic acid decarboxylase via the estrogen receptor-α in female mice liver.
American journal of physiology. Gastrointestinal and liver physiology
Ma Q,Zhao J,Cao W,Liu J,Cui S
Sun Feb 15 00:00:00 UTC 2015
3,4-dihydroxybenzalacetone protects against Parkinson's disease-related neurotoxin 6-OHDA through Akt/Nrf2/glutathione pathway.
Journal of cellular biochemistry
Gunjima K,Tomiyama R,Takakura K,Yamada T,Hashida K,Nakamura Y,Konishi T,Matsugo S,Hori O
Wed Jan 01 00:00:00 UTC 2014
3,4-dihydroxybenzalacetone protects against Parkinson's disease-related neurotoxin 6-OHDA through Akt/Nrf2/glutathione pathway.
Journal of cellular biochemistry
Gunjima K,Tomiyama R,Takakura K,Yamada T,Hashida K,Nakamura Y,Konishi T,Matsugo S,Hori O
Wed Jan 01 00:00:00 UTC 2014
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
Longevity & healthspan
Brown-Borg HM,Rakoczy S,Wonderlich JA,Armstrong V,Rojanathammanee L
Tue Jan 13 00:00:00 UTC 2015
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
Longevity & healthspan
Brown-Borg HM,Rakoczy S,Wonderlich JA,Armstrong V,Rojanathammanee L
Tue Jan 13 00:00:00 UTC 2015
Differential regulation of γ-glutamyltransferase and glutamate cysteine ligase expression after mitochondrial uncoupling: γ-glutamyltransferase is regulated in an Nrf2- and NFκB-independent manner.
Free radical research
Ravuri C,Svineng G,Huseby NE
Wed May 01 00:00:00 UTC 2013
Differential regulation of γ-glutamyltransferase and glutamate cysteine ligase expression after mitochondrial uncoupling: γ-glutamyltransferase is regulated in an Nrf2- and NFκB-independent manner.
Free radical research
Ravuri C,Svineng G,Huseby NE
Wed May 01 00:00:00 UTC 2013
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Cell reports
Wu H,Xiao Y,Zhang S,Ji S,Wei L,Fan F,Geng J,Tian J,Sun X,Qin F,Jin C,Lin J,Yin ZY,Zhang T,Luo L,Li Y,Song S,Lin SC,Deng X,Camargo F,Avruch J,Chen L,Zhou D
Thu May 30 00:00:00 UTC 2013
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Cell reports
Wu H,Xiao Y,Zhang S,Ji S,Wei L,Fan F,Geng J,Tian J,Sun X,Qin F,Jin C,Lin J,Yin ZY,Zhang T,Luo L,Li Y,Song S,Lin SC,Deng X,Camargo F,Avruch J,Chen L,Zhou D
Thu May 30 00:00:00 UTC 2013
