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Proteintech
GCM2 Polyclonal Antibody
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Product Details
21088-1-AP
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GCM2 Fusion Protein Ag15334 (157-506 aa encoded by BC069603)
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: HDHPRPESK SETEARRSAI KRQMASFYQP QKKRIRESEA EENQDSSGHF SNIPPLENPE DFDIVTETSF PIPGQPCPSF PKSDVYKATC DLATFQGDKM PPFQKYSSPR IYLPRPPCSY ELANPGYTNS SPYPTLYKDS TSIPNDTDWV HLNTLQCNVN SYSSYERSFD FTNKQHGWKP ALGKPSLVER TNHGQFQAMA TRPYYNPELP CRYLTTPPPG APALQTVITT TTKVSYQAYQ PPAMKYSDSV REVKSLSSCN YAPEDTGMSV YPEPWGPPVT VTRAASPSGP PPMKIAGDCR AIRPTVAIPH EPVSSRTDEA ETWDVCLSGL GSAVSYSDRV GPFFTYNNED F (157-506 aa encoded by BC069603)
Target Information
This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chorion-specific transcription factor GCMb; GCM motif protein 2; glial cells missing 2; Glial cells missing homolog 2; glial cells missing homolog b; glide/gcm protein homolog; hGCMb; mGCMb; RP3-417M14.3
Gene Aliases: Gcm-rs1; Gcm1; Gcm1-rs2; GCM2; GCMB; hGCMb
UniProt ID: (Human) O75603, (Mouse) O09102
Entrez Gene ID: (Human) 9247, (Mouse) 107889
transcription from RNA polymerase II promoter
cellular calcium ion homeostasis
multicellular organism development
cellular phosphate ion homeostasis
gliogenesis
positive regulation of transcription from RNA polymerase II promoter
parathyroid gland development
transcription, DNA-templated
regulation of transcription, DNA-templated
cell differentiation
negative regulation of apoptotic process
cellular response to organic substance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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