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Invitrogen
GCN5 Monoclonal Antibody (S.775.4)
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Product Details
MA5-14884
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
S.775.4
Immunogen
Synthetic peptide corresponding to the amino terminus of human GCN5L2
Conjugate
Form
Liquid
Concentration
134 µg/mL
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10978625
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with the related PCAF protein.
Target Information
SAGA (Spt-Ada-Gen5 histone acetyltransferase complex) is a histoneacetylase complex which has Gcn5p as catalyst subunit and functions overlapping with the fundamental transcription factor TFIID which has Taf1p as catalyst subunit. However, SAGA and TFIID have different allotment and each accomplishes the important role in the transcription for Housekeeping gene group and Stress Responding gene group. Also, SAGA is a gigantic protein complex which is composed of Ada protein group (5 kinds), TBP related protein group (4 kinds), TAF protein group (5 kinds that also pertain to TFIID), and other protein groups (>6 kinds). As its molecular function, there is the chemical modification of histone, or the recruitment by direct interaction of transcription regulating factor on DNA, or the control of transcription starting reaction by TBP. Gcn5p that show histoneacetylase activity is one kind of the above-mentioned Ada protein group, and in the case of budding yeast it is composed of 439 amino acid residues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; GCN5 general control of amino acid synthesis-like 2; general control of amino acid synthesis 5-like 2; General control of amino acid synthesis protein 5-like 2; general control of amino acid synthesis, yeast homolog-like 2; General control of amino acid synthesis, yeast, homolog-like 2; general control of amino acid synthesis-like 2; hGCN5; Histone acetyltransferase GCN5; Histone acetyltransferase KAT2A; Histone glutaryltransferase KAT2A; Histone succinyltransferase KAT2A; hsGCN5; K(lysine) acetyltransferase 2A; KATA2; Lysine acetyltransferase 2A; MmGCN5; PCAF-B/GCN5; STAF97
Gene Aliases: 1110051E14Rik; AW212720; GCN5; GCN5L2; hGCN5; KAT2A; mmGCN5; PCAF-b
UniProt ID: (Human) Q92830, (Mouse) Q9JHD2
Entrez Gene ID: (Human) 2648, (Mouse) 14534, (Rat) 303539
chromatin binding
transcription coactivator activity
histone acetyltransferase activity
protein binding
transcription factor binding
H3 histone acetyltransferase activity
protein phosphatase binding
histone deacetylase binding
histone acetyltransferase activity (H4-K12 specific)
N-acetyltransferase activity
acetyltransferase activity
transferase activity
transferase activity, transferring acyl groups
in utero embryonic development
somitogenesis
neural tube closure
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cell proliferation
response to organic cyclic compound
viral process
histone deubiquitination
telencephalon development
metencephalon development
midbrain development
positive regulation of cell projection organization
regulation of protein stability
response to nutrient levels
positive regulation of histone acetylation
multicellular organism growth
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
histone H3 acetylation
histone H4-K12 acetylation
histone H3-K14 acetylation
positive regulation of gene expression, epigenetic
intracellular distribution of mitochondria
cardiac muscle cell differentiation
cellular response to tumor necrosis factor
alpha-tubulin acetylation
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
cellular response to nerve growth factor stimulus
positive regulation of transcription regulatory region DNA binding
transcription, DNA-templated
regulation of transcription, DNA-templated
nervous system development
histone acetylation
regulation of nucleic acid-templated transcription
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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