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Proteintech
GCOM1 Polyclonal Antibody
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Product Details
18129-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GCOM1 Fusion Protein Ag12708 (118-466 aa encoded by BC101645)
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MYGDYDEMR QKIRQLTQEL SVSHAQQEYL ENHIQTQSSA LDRFNAMNSA LASDSIGLQK TLVDVTLENS NIKDQIRNLQ QTYEASMDKL REKQRQLEVA QVENQLLKMK VESSQEANAE VMREMTKKLY SQYEEKLQEE QRKHSAEKEA LLEETNSFLK AIEEANKKMQ AAEISLEEKD QRIGELDRLI ERMEKERHQL QLQLLEHETE MSGELTDSDK ERYQQLEEAS ASLRERIRHL DDMVHCQQKK VKQMVEEIES LKKKLQQKQL LILQLLEKIS FLEGENNELQ SRLDYLTETQ AKTEVETREI GVGCDLLPSQ TGRTREIVMP SRNYTPYTRV LELTMKKTLT (118-466 aa encoded by BC101645)
Target Information
MYOZAP, also known as GRINL1A, is a 54 kDa highly conserved cardiac protein. It is strongly expressed in the heart and lung and is a novel component of intercalated disc. MYOZAP interacts with myosin phosphatase-RhoA interacting protein (MRIP) and acts as an activator of Rho-dependent SRF signaling. Knockdown study in zebrafish results in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: gcom; Gcom2; GRINL1A; GRINL1A combined protein; GRINL1A complex locus 1; GRINL1A complex locus protein 1; GRINL1A complex locus upstream; GRINL1A upstream protein; Gup; myocardial intercalated disc protein; Myocardial zonula adherens protein; myocardium-enriched ZO1-associated protein; myocardium-enriched zonula adherens protein; myocardium-enriched zonula occludens-1-associated protein; myozap; MYZAP-POLR2M
Gene Aliases: AA407270; AV006038; GCOM1; Gm640; Grinl1a7; Gup; MYOZAP; MYZAP
UniProt ID: (Human) P0CAP1, (Mouse) Q3UIJ9, (Rat) Q5EB94
Entrez Gene ID: (Human) 100820829, (Mouse) 102371, (Rat) 363091
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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