Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MATPNNLTPT NCSWWPISAL ESDAAKPAEA PDAPEAASPA HWPRESLVLY HWTQSFSSQK VRLVIAEKGL VCEERDVSLP QSEHKEPWFM RLNLGEEVPV IIHRDNIISD YDQIIDYVER TFTGEHVVAL MPEVGSLQHA RVLQYRELLD ALPMDAYTHG CILHPELTTD SMIPKYATAE IRRHLANATT DLMKLDHEEE PQLSEPYLSK QKKLMAKILE HDDVSYLKKI LGELAMVLDQ IEAELEKRKL ENEGQKCELW LCGCAFTLAD VLLGATLHRL KFLGLSKKYW EDGSRPNLQS FFERVQRRFA FRKVLGDIHT TLLSAVIPNA FRLVKRKPPS FFGASFLMGS LGGMGYFAYW YLKKKYI
The ganglioside GD3 synthase causes cell differentiation with neurite sprouting when transfected into the mouse neuroblastoma cell line Neuro2a. After differentiation, the expression of several genes is upregulated, including one that encodes a protein termed ganglioside-induced differentiation-associated protein 1 (Gdap1). A similar gene was found in humans, and mutations in the human gene are associated with Charcot-Marie-Tooth type 4A disease. The protein encoded by this gene is similar in sequence to the human GDAP1 protein. Several transcript variants encoding different isoforms, as well as a noncoding transcript variant, have been found for this gene.
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Protein Aliases: ganglioside induced differentiation associated protein 1-like 1; Ganglioside-induced differentiation-associated protein 1-like 1; ganglioside-induced differentiation-associated protein 1-like 1-like; GDAP1-L1
Gene Aliases: dJ881L22.1; dJ995J12.1.1; Gdap1l; GDAP1L1
UniProt ID: (Human) Q96MZ0
Entrez Gene ID: (Human) 78997, (Mouse) 228858, (Rat) 311616, (Rabbit) 100347940
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