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GDF1 Antibody (PA5-119770) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded rat brain tissue using GDF1 Polyclonal Antibody (Product # PA5-119770). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the GDF1 antibody at a dilution of 1:500... View More
Product Details
PA5-119770
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within C-terminal human GDF1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2913342
Product Specific Information
Positive Control: SH-SY5Y cell lysate, MCF-7 cell lysate, rat brain tissue.
Subcellular Location: Secreted.
Target Information
Growth differentiation factors (GDFs) are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. GDF1 was initially identified as a temporally expressed gene in the mouse central nervous system during embryonic development, with only one isoform detected in adult tissues. GDF1 is required for left-right patterning during development and directly interacts with Nodal, another member of the TGF-beta superfamily. It has been suggested that GDF1 regulates the activity and signaling range of Nodal through direct interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Embryonic growth/differentiation factor 1; GDF-1
Gene Aliases: DORV; DTGA3; GDF1; RAI
UniProt ID: (Human) P27539
Entrez Gene ID: (Human) 2657, (Rat) 306351
in utero embryonic development
signal transduction
endoderm development
mesoderm development
positive regulation of pathway-restricted SMAD protein phosphorylation
BMP signaling pathway
growth
regulation of apoptotic process
regulation of MAPK cascade
cell development
SMAD protein signal transduction
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