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Invitrogen
GEF-H1 Recombinant Rabbit Monoclonal Antibody (JG36-46)
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Product Details
MA5-34750
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JG36-46
Immunogen
Synthetic peptide within Human GEF H1 aa 937-986
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2848658
Product Specific Information
Positive Control: 293T, A431, HUVEC, SH-SY-5Y, rat brain tissue, human tonsil tissue, mouse testis tissue.
Target Information
GEF-H1 activates Rho GTPases by promoting the exchange of GDP and GTP. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. GEF-H1 may be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp547L106; DKFZp547P1516; FLJ45440; GEF-H1; Guanine nucleotide exchange factor H1; Microtubule-regulated Rho-GEF; OTTHUMP00000018855; Proliferating cell nucleolar antigen p40; Rho guanine nucleotide exchange factor 2; Rho/Rac guanine nucleotide exchange factor (GEF) 2
Gene Aliases: ARHGEF2; GEF; GEF-H1; GEFH1; KIAA0651; LFP40; P40
UniProt ID: (Human) D3DVA6
Entrez Gene ID: (Human) 9181
establishment of mitotic spindle orientation
cell morphogenesis
intracellular protein transport
actin filament organization
negative regulation of microtubule depolymerization
mitotic nuclear division
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
regulation of Rho protein signal transduction
intracellular signal transduction
regulation of cell proliferation
positive regulation of apoptotic process
positive regulation of GTPase activity
innate immune response
positive regulation of transcription from RNA polymerase II promoter
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of neurogenesis
regulation of small GTPase mediated signal transduction
positive regulation of NF-kappaB transcription factor activity
cell division
negative regulation of necroptotic process
cellular response to muramyl dipeptide
cellular response to tumor necrosis factor
cellular hyperosmotic response
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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