Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 6
GFRAL Antibody (PA5-47769) in IHC (P)
Immunohistochemical analysis of GFRAL in immersion fixed paraffin-embedded sections of mouse spinal cord. Samples were incubated with GFRAL polyclonal antibody (Product # PA5-47769) using a dilution of 5 µg/mL for 1 hour at room temperature followed by Anti-Sheep IgG VisUCyte™ HRP Polymer Antibody. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Anti... View More
Product Details
PA5-47769
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant mouse GFR alpha-like isoform A Gln20-Gly349
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607220
Product Specific Information
In direct ELISA, less than 1% cross-reactivity with recombinant mouse (rm) GFR alpha -3 and rmGFR alpha -4 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GDNF family receptor alpha-like; GDNF receptor alpha-like
Gene Aliases: AY457637; Gfral; Gral
UniProt ID: (Mouse) Q6SJE0
Entrez Gene ID: (Mouse) 404194
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support