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Peptide sequence: AKLLKSKNPD DLQEANKLIK SMVKEDEARI QKVTKRLHTL EEVNNNVRLL
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 85%
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADP-ribosylation factor-binding protein GGA3; Golgi-localized, gamma ear-containing, ARF-binding protein 3
Gene Aliases: GGA3; KIAA0154
UniProt ID: (Human) Q9NZ52
Entrez Gene ID: (Human) 23163
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