Abnova

GHRL Monoclonal Antibody (4B8)

View all (26) Ghrelin antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

H00051738-M09

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1 µg/mL
-

ELISA (ELISA)

1 ng/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

4B8

Immunogen

GHRL (AAH25791.1, 1 a.a. approximately 117 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MPSPGTVCSL LLLGMLWLDL AMAGSSFLSP EHQRVQQRKE SKKPPAKLQP RALAGWLRPE DGGQAEGAED EMEVRFNAPF DVGIKLSGVQ YQQHSQALGK FLQDILWEEA KEAPADK

Target Information

GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an the ligand for the growth hormone secretagogue receptor type 1 and is involved in regulating growth hormone release. Ghrelin has an appeptite-stimulating effect and induces adiposity and stimulates gastric acid secretion. Obestatin may be the ligand for the orphan G protein-coupled receptor GPR39 and is involved in satiety and can have an appetite-reducing effect resulting in decreased food intake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AMCBX1; Appetite-regulating hormone; FIP-3; FIP3; Fip3p; ghrelin 27; ghrelin 28; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin; ghrelin/obestatin preprohormone; Growth hormone secretagogue; Growth hormone-releasing peptide; IKK-gamma; In2c-preproghrelin; IP; IP1; IP2; IPD2; Motilin-related peptide; NEMO; OTTHUMP00000207794; OTTHUMP00000207795; OTTHUMP00000207796; OTTHUMP00000207798; prepro-appetite regulatory hormone; preproghrelin; Protein M46

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Gene Aliases: GHRL; MTLRP; UNQ524/PRO1066

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UniProt ID: (Human) Q9UBU3

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Entrez Gene ID: (Human) 51738

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Function(s)
G-protein coupled receptor binding protein binding growth hormone-releasing hormone activity protein tyrosine kinase activator activity ghrelin receptor binding
Process(es)
activation of MAPK activity gastric acid secretion negative regulation of endothelial cell proliferation glucose metabolic process G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration actin polymerization or depolymerization adult feeding behavior response to hormone hormone-mediated signaling pathway dendrite development negative regulation of angiogenesis growth hormone secretion positive regulation of insulin secretion regulation of response to food positive regulation of appetite negative regulation of interleukin-1 beta production negative regulation of locomotion positive regulation of multicellular organism growth regulation of cell proliferation negative regulation of circadian sleep/wake cycle, REM sleep negative regulation of tumor necrosis factor biosynthetic process negative regulation of apoptotic process cortisol secretion response to estrogen negative regulation of interleukin-6 biosynthetic process positive regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of insulin secretion decidualization negative regulation of inflammatory response cartilage development positive regulation of corticotropin secretion positive regulation of cortisol secretion positive regulation of synapse assembly excitatory postsynaptic potential positive regulation of growth hormone secretion positive regulation of growth hormone receptor signaling pathway positive regulation of protein tyrosine kinase activity negative regulation of energy homeostasis positive regulation of energy homeostasis
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