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Abnova
GIMAP8 Polyclonal Antibody, MaxPab™
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Product Details
H00155038-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GIMAP8 (NP_783161, 1 a.a. approximately 665 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSEQSCQMSE LRLLLLGKCR SGKSATGNAI LGKHVFKSKF SDQTVIKMCQ RESWVLRERK VVVIDTPDLF SSIACAEDKQ RNIQHCLELS APSLHALLLV IAIGHFTRED EETAKGIQQV FGAEARRHII IVFTRKDDLG DDLLQDFIEK NKPLKQLVQD YEGRYCIFNN KTNSKDEQIT QVLELLRKVE SLVNTNGGPY HVNFKTEGSR FQDCVNEAAS QEGDKPQGPR ERQLQSTGPE QNPGTSELTV LLVGKRGAGK SAAGNSILGR QAFQTGFSEQ SVTQSFLSES RSWRKKKVSI IDAPDISSLK NIDSEVRKHI CTGPHAFLLV TPLGFYTKND EAVLSTIQNN FGEKFFEYMI ILLTRKEDLG DQDLDTFLRN SNKALYGLIQ KCKNRYSAFN YRATGEEEQR QADELLEKIE SMVHQNGNKH CVFREKETLN IVLVGRSGTG KSATGNSILG SLVFTSRLRA QPVTKTSQSG RRTWDGQEVV VVDTPSFNQM LDVEKDPSRL EEEVKRCLSC CEKGDTFFVL VFQLGRFTEE DKTAVAKLEA IFGADFTKYA IMLFTRKEDL GAGNLEDFMK NSDNKALRRI FKKCGRRVCA FNNKETGQAQ ETQVKALLTK VNDLRKESGW SGYPHTQENV SKLIKNVQEM SQAEKLLKNL IGILQ
Target Information
The GIMAP8 gene, part of the GTPase of the Immunity-Associated Proteins (GIMAP) family, is located on chromosome 7q36.1. This gene encodes a protein that is predominantly expressed in immune cells, including T and B lymphocytes. GIMAP8 is involved in the regulation of lymphocyte survival and development, particularly during the early and late stages of T cell development in the thymus, as well as during B cell maturation. Studies have shown that GIMAP8 expression levels are significantly altered in various cancers, including breast and lung adenocarcinoma, where its upregulation in tumor tissues correlates with improved overall survival in specific cancer subtypes. This suggests a potential role for GIMAP8 in tumor immune surveillance and as a prognostic biomarker. Additionally, GIMAP8's functions appear essential but redundant enough that mouse models deficient in this gene do not exhibit major defects in T or B cell development, indicating compensation by other family members.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTPase IMAP family member 8; hIAN6; human immune associated nucleotide 6; IAN-9; Immune-associated nucleotide-binding protein 9; Protein IanT
Gene Aliases: GIMAP8; IAN-9; IAN6; IAN9; IANT
UniProt ID: (Human) Q8ND71
Entrez Gene ID: (Human) 155038
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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