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Invitrogen
GIP Polyclonal Antibody
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GIP Antibody (PA5-120977) in IHC (P)
Immunohistochemistry analysis of GIP in paraffin-embedded mouse intestine. Samples were incubated with GIP Polyclonal antibody (Product # PA5-120977) using a dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-120977
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 22-153 of human GIP (NP_004114.1).
Conjugate
Form
Liquid
Concentration
0.58 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2914549
Product Specific Information
Positive test controls include: Mouse small intestine. The target is usually found in the following locations: Secreted.
Immunogen sequence: EKKEGHFSAL PSLPVGSHAK VSSPQPRGPR YAEGTFISDY SIAMDKIHQQ DFVNWLLAQK GKKNDWKHNI TQREARALEL ASQANRKEEE AVEPQSSPAK NPSDEDLLRD LLIQELLACL LDQTNLCRLR SR
Target Information
This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gastric inhibitory polypeptide; GIP; Glucose-dependent insulinotropic peptide; Glucose-dependent insulinotropic polypeptide; Incretin hormone; Rabbit Anti GIP
Gene Aliases: GIP; Gludins; RATGLUDINS
UniProt ID: (Human) P09681, (Mouse) P48756, (Rat) Q06145
Entrez Gene ID: (Human) 2695, (Mouse) 14607, (Rat) 25040
signal transduction
female pregnancy
memory
adult locomotory behavior
response to glucose
response to selenium ion
response to acidic pH
positive regulation of glucose transport
response to organic cyclic compound
sensory perception of pain
endocrine pancreas development
positive regulation of insulin secretion
response to lipid
exploration behavior
response to drug
response to starvation
response to amino acid
response to peptide hormone
positive regulation of cAMP-mediated signaling
response to axon injury
regulation of insulin secretion
digestive system development
long-term synaptic potentiation
positive regulation of glucagon secretion
triglyceride homeostasis
positive regulation of synaptic transmission
response to carbohydrate
response to nutrient levels
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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