Proteintech

GIPC1 Polyclonal Antibody

GIPC1 Antibody in Immunocytochemistry (ICC/IF)

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GIPC1 Antibody (14822-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 14822-1-AP (GIPC1 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

GIPC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

GIPC1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14822-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:600-1:4000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GIPC1 Fusion Protein Ag6597 (1-333 aa encoded by BC000410)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPLGLGRRK KAPPLVENEE AEPGRGGLGV GEPGPLGGGG SGGPQMGLPP PPPALRPRLV FHTQLAHGSP TGRIEGFTNV KELYGKIAEA FRLPTAEVMF CTLNTHKVDM DKLLGGQIGL EDFIFAHVKG QRKEVEVFKS EDALGLTITD NGAGYAFIKR IKEGSVIDHI HLISVGDMIE AINGQSLLGC RHYEVARLLK ELPRGRTFTL KLTEPRKAFD MISQRSAGGR PGSGPQLGTG RGTLRLRSRG PATVEDLPSA FEEKAIEKVD DLLESYMGIR DTELAATMVE LGKDKRNPDE LAEALDERLG DFAFPDEFVF DVWGAIGDAK VGRY (1-333 aa encoded by BC000410)

Target Information

GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

G-alpha interacting protein interacting protein, C terminus 1 regulates epileptogenesis by increasing the expression of metabotropic glutamate receptor 7.

CNS neuroscience & therapeutics

Liu Y,Wang Y,Yang J,Xu T,Tan C,Zhang P,Liu Q,Chen Y

Sat Jan 01 00:00:00 UTC 2022

GIPC1 CGG Repeat Expansion Is Associated with Movement Disorders.

Annals of neurology

Fan Y,Shen S,Yang J,Yao D,Li M,Mao C,Wang Y,Hao X,Ma D,Li J,Shi J,Guo M,Li S,Yuan Y,Liu F,Yang Z,Zhang S,Hu Z,Fan L,Liu H,Zhang C,Wang Y,Wang Q,Zheng H,He Y,Song B,Xu Y,Shi C

Sun May 01 00:00:00 UTC 2022

SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt.

Developmental cell

Burckhardt CJ,Minna JD,Danuser G

Mon Apr 19 00:00:00 UTC 2021

G protein-coupled receptor GPR151 is involved in trigeminal neuropathic pain through the induction of Gβγ/extracellular signal-regulated kinase-mediated neuroinflammation in the trigeminal ganglion.

Pain

Jiang BC,Zhang J,Wu B,Jiang M,Cao H,Wu H,Gao YJ

Sat May 01 00:00:00 UTC 2021

Myosin VI maintains the actin-dependent organization of the tubulobulbar complexes required for endocytosis during mouse spermiogenesis†‡.

Biology of reproduction

Zakrzewski P,Suwińska A,Lenartowski R,Rędowicz MJ,Buss F,Lenartowska M

Wed Apr 15 00:00:00 UTC 2020

Myosin VI maintains the actin-dependent organization of the tubulobulbar complexes required for endocytosis during mouse spermiogenesis†‡.

Biology of reproduction

Zakrzewski P,Suwińska A,Lenartowski R,Rędowicz MJ,Buss F,Lenartowska M

Wed Apr 15 00:00:00 UTC 2020

Expansion of GGC Repeat in GIPC1 Is Associated with Oculopharyngodistal Myopathy.

American journal of human genetics

Deng J,Yu J,Li P,Luan X,Cao L,Zhao J,Yu M,Zhang W,Lv H,Xie Z,Meng L,Zheng Y,Zhao Y,Gang Q,Wang Q,Liu J,Zhu M,Guo X,Su Y,Liang Y,Liang F,Hayashi T,Maeda MH,Sato T,Ura S,Oya Y,Ogasawara M,Iida A,Nishino I,Zhou C,Yan C,Yuan Y,Hong D,Wang Z

Thu Jun 04 00:00:00 UTC 2020

GIPC proteins negatively modulate Plexind1 signaling during vascular development.

eLife

Carretero-Ortega J,Chhangawala Z,Hunt S,Narvaez C,Menéndez-González J,Gay CM,Zygmunt T,Li X,Torres-Vázquez J

Fri May 03 00:00:00 UTC 2019

BMP9 directly induces rapid GSK3-β phosphorylation in a Wnt-independent manner through class I PI3K-Akt axis in osteoblasts.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Eiraku N,Chiba N,Nakamura T,Amir MS,Seong CH,Ohnishi T,Kusuyama J,Noguchi K,Matsuguchi T

Fri Nov 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: GAIP C-terminus-interacting protein; GIPC PDZ domain containing family, member 1; GLUT1 C-terminal binding protein; GLUT1 C-terminal-binding protein; GLUT1CBP; IGF-1 receptor interacting protein 1; neurophilin1-IP; PDZ domain-containing protein GIPC1; regulator of G-protein signaling 19 interacting protein 1; regulator of G-protein signalling 19 interacting protein 1; RGS-GAIP interacting protein C-terminus; RGS-GAIP interacting protein GIPC; RGS-GAIP interacting protein, C-terminus; RGS-GAIP-interacting protein; RGS19-interacting protein 1; semaF cytoplasmic domain associated protein; SemaF cytoplasmic domain-associated protein 1; SEMCAP-1; Synectin; Tax interacting protein, clone 2; Tax interaction protein 2; TIP-2

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Gene Aliases: C19orf3; GIPC; GIPC1; GLUT1CBP; Glut1CIP; Hs.6454; IIP-1; NIP; Rgs19; RGS19IP1; SEMCAP; Semcap1; SYNECTIIN; SYNECTIN; TaxIP2; TIP-2

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UniProt ID: (Human) O14908, (Rat) Q9Z254, (Mouse) Q9Z0G0

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Entrez Gene ID: (Human) 10755, (Rat) 83823, (Mouse) 67903

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Function(s)

actin binding receptor binding protein binding myosin binding PDZ domain binding protein homodimerization activity cadherin binding involved in cell-cell adhesion GTPase activator activity

Process(es)

protein targeting chemical synaptic transmission glutamate secretion positive regulation of transforming growth factor beta receptor signaling pathway regulation of protein stability negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of cytokinesis endothelial cell migration regulation of synaptic plasticity G-protein coupled receptor signaling pathway cell-cell adhesion positive regulation of GTPase activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GIPC1 Polyclonal Antibody

GIPC1 Antibody (14822-1-AP) in ICC/IF

Product Details

14822-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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