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Invitrogen
GIPR Polyclonal Antibody
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FIGURE: 1 / 3
GIPR Antibody (PA5-33585) in ICC/IF
Immunofluorescence analysis of GIPR was performed using 90% confluent log phase 3T3-L1 cells differentiated to adipocytes. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with GIPR Rabbit Polyclonal Antibody (Product # PA5-33585) at 5 microgram/mL in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa F... View More
Product Details
PA5-33585
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GIPR.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550965
Product Specific Information
BLAST analysis of the peptide immunogen showed 100% homology with human protein GHRHR.
Percent identity with other species by BLAST analysis: Human, Gorilla, Bovine, Dog, Panda (100%) Horse, Rabbit (94%) Marmoset, Hamster (88%) Rat (82%).
Target Information
GIPR encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gastric inhibitory polypeptide receptor; GIP receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor
Gene Aliases: GIP-R; GIPR; Gm1081; Gm160; PGQTL2
UniProt ID: (Human) P48546, (Mouse) Q0P543
Entrez Gene ID: (Human) 2696, (Dog) 484439, (Mouse) 381853
desensitization of G-protein coupled receptor protein signaling pathway
generation of precursor metabolites and energy
cell surface receptor signaling pathway
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
response to nutrient
response to glucose
endocrine pancreas development
positive regulation of insulin secretion
gastric inhibitory peptide signaling pathway
response to axon injury
regulation of insulin secretion
response to calcium ion
response to fatty acid
signal transduction
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
positive regulation of cAMP biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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