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Proteintech
GIYD2 Polyclonal Antibody
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Product Details
21158-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GIYD2 Fusion Protein Ag13094 (1-275 aa encoded by BC000803)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGPAGVAAR PGRFFGVYLL YCLNPRYRGR VYVGFTVNTA RRVQQHNGGR KKGGAWRTSG RGPWEMVLVV HGFPSSVAAL RFEWAWQHPH ASRRLAHVGP RLRGETAFAF HLRVLAHMLR APPWARLPLT LRWVRPDLRQ DLCLPPPPHV PLAFGPPPPQ APAPRRRAGP FDDAEPEPDQ GDPGACCSLC AQTIQDEEGP LCCPHPGCLL RAHVICLAEE FLQEEPGQLL PLEGQCPCCE KSLLWGDLIW LCQMDTEKEV EDSELEEAHW TDLLET (1-275 aa encoded by B C000803)
Target Information
This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GIY-YIG domain containing 2; GIY-YIG domain-containing protein 1; SLX1 homolog B; SLX1 structure-specific endonuclease subunit homolog B; SLX1A; SLX1B; Structure-specific endonuclease subunit SLX1
Gene Aliases: 1110030E23Rik; 2410170E21Rik; 4833422P03Rik; AI853643; GIYD1; GIYD2; SLX1; SLX1A; SLX1B
UniProt ID: (Human) Q9BQ83, (Mouse) Q8BX32
Entrez Gene ID: (Human) 79008, (Mouse) 75764
endodeoxyribonuclease activity
protein binding
crossover junction endodeoxyribonuclease activity
5'-flap endonuclease activity
metal ion binding
nuclease activity
endonuclease activity
hydrolase activity
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
double-strand break repair via homologous recombination
DNA repair
DNA double-strand break processing involved in repair via single-strand annealing
interstrand cross-link repair
nucleic acid phosphodiester bond hydrolysis
t-circle formation
positive regulation of t-circle formation
DNA metabolic process
DNA recombination
cellular response to DNA damage stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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