Proteintech

GJB3 Polyclonal Antibody

GJB3 Antibody in Immunocytochemistry (ICC/IF)

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GJB3 Antibody (12880-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 12880-1-AP (GJB3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

GJB3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

GJB3 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12880-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Chimpanzee, Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GJB3 Fusion Protein Ag3839 (101-270 aa encoded by BC012918)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RERRHRQKH GDQCAKLYDN AGKKHGGLWW TYLFSLIFKL IIEFLFLYLL HTLWHGFNMP RLVQCANVAP CPNIVDCYIA RPTEKKIFTY FMVGASAVCI VLTICELCYL ICHRVLRGLH KDKPRGGCSP SSSASRASTC RCHHKLVEAG EVDPDPGNNK LQASAPNLTP I (101-270 aa encoded by BC012918)

Target Information

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes.

eLife

Monterisi S,Michl J,Hulikova A,Koth J,Bridges EM,Hill AE,Abdullayeva G,Bodmer WF,Swietach P

Thu Sep 15 00:00:00 UTC 2022

GJB3 promotes pancreatic cancer liver metastasis by enhancing the polarization and survival of neutrophil.

Frontiers in immunology

Huo Y,Zhou Y,Zheng J,Jin G,Tao L,Yao H,Zhang J,Sun Y,Liu Y,Hu LP

Tue Nov 08 00:00:00 UTC 2022

GJB3 promotes pancreatic cancer liver metastasis by enhancing the polarization and survival of neutrophil.

Frontiers in immunology

Huo Y,Zhou Y,Zheng J,Jin G,Tao L,Yao H,Zhang J,Sun Y,Liu Y,Hu LP

Tue Nov 08 00:00:00 UTC 2022

GJB3 promotes pancreatic cancer liver metastasis by enhancing the polarization and survival of neutrophil.

Frontiers in immunology

Huo Y,Zhou Y,Zheng J,Jin G,Tao L,Yao H,Zhang J,Sun Y,Liu Y,Hu LP

Tue Nov 08 00:00:00 UTC 2022

GJB3 promotes pancreatic cancer liver metastasis by enhancing the polarization and survival of neutrophil.

Frontiers in immunology

Huo Y,Zhou Y,Zheng J,Jin G,Tao L,Yao H,Zhang J,Sun Y,Liu Y,Hu LP

Tue Nov 08 00:00:00 UTC 2022

Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation.

Science translational medicine

Lorusso G,Wyss CB,Kuonen F,Vannini N,Billottet C,Duffey N,Pineau R,Lan Q,Wirapati P,Barras D,Tancredi A,Lyck R,Lehr HA,Engelhardt B,Delorenzi M,Bikfalvi A,Rüegg C

Wed Sep 07 00:00:00 UTC 2022

Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation.

Science translational medicine

Lorusso G,Wyss CB,Kuonen F,Vannini N,Billottet C,Duffey N,Pineau R,Lan Q,Wirapati P,Barras D,Tancredi A,Lyck R,Lehr HA,Engelhardt B,Delorenzi M,Bikfalvi A,Rüegg C

Wed Sep 07 00:00:00 UTC 2022

Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation.

Science translational medicine

Lorusso G,Wyss CB,Kuonen F,Vannini N,Billottet C,Duffey N,Pineau R,Lan Q,Wirapati P,Barras D,Tancredi A,Lyck R,Lehr HA,Engelhardt B,Delorenzi M,Bikfalvi A,Rüegg C

Wed Sep 07 00:00:00 UTC 2022

Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation.

Science translational medicine

Lorusso G,Wyss CB,Kuonen F,Vannini N,Billottet C,Duffey N,Pineau R,Lan Q,Wirapati P,Barras D,Tancredi A,Lyck R,Lehr HA,Engelhardt B,Delorenzi M,Bikfalvi A,Rüegg C

Wed Sep 07 00:00:00 UTC 2022

Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Huang TW,Iyer AA,Manalo JM,Woo J,Bosquez Huerta NA,McGovern MM,Schrewe H,Pereira FA,Groves AK,Ohlemiller KK,Deneen B

Wed Aug 25 00:00:00 UTC 2021

In vitro fertilization causes excessive glycogen accumulation in mouse placenta.

Placenta

Dong J,Guo X,Qian C,Wang J,Lei H,Chen S,Wang X

Fri Oct 01 00:00:00 UTC 2021

Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.

Genes to cells : devoted to molecular & cellular mechanisms

Yamauchi Y,Nita A,Nishiyama M,Muto Y,Shimizu H,Nakatsumi H,Nakayama KI

Mon Jun 01 00:00:00 UTC 2020

Comparative analysis of molecular signatures suggests the use of gabapentin for the management of endometriosis-associated pain.

Journal of pain research

Bellessort B,Bachelot A,Grouthier V,De Lombares C,Narboux-Neme N,Garagnani P,Pirazzini C,Astigiano S,Mastracci L,Fontaine A,Alfama G,Duvernois-Berthet E,Levi G

Thu Mar 14 00:00:00 UTC 2024

Comparative analysis of molecular signatures suggests the use of gabapentin for the management of endometriosis-associated pain.

Journal of pain research

Bellessort B,Bachelot A,Grouthier V,De Lombares C,Narboux-Neme N,Garagnani P,Pirazzini C,Astigiano S,Mastracci L,Fontaine A,Alfama G,Duvernois-Berthet E,Levi G

Thu Mar 14 00:00:00 UTC 2024

Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss.

Cell reports

Hosoya M,Fujioka M,Sone T,Okamoto S,Akamatsu W,Ukai H,Ueda HR,Ogawa K,Matsunaga T,Okano H

Tue Jan 03 00:00:00 UTC 2017

Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss.

Cell reports

Hosoya M,Fujioka M,Sone T,Okamoto S,Akamatsu W,Ukai H,Ueda HR,Ogawa K,Matsunaga T,Okano H

Tue Jan 03 00:00:00 UTC 2017

Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea.

Scientific reports

Hosoya M,Fujioka M,Ogawa K,Okano H

Fri Feb 26 00:00:00 UTC 2016

Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea.

Scientific reports

Hosoya M,Fujioka M,Ogawa K,Okano H

Fri Feb 26 00:00:00 UTC 2016

Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea.

Scientific reports

Hosoya M,Fujioka M,Ogawa K,Okano H

Fri Feb 26 00:00:00 UTC 2016

Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea.

Scientific reports

Hosoya M,Fujioka M,Ogawa K,Okano H

Fri Feb 26 00:00:00 UTC 2016

FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development.

Stem cells (Dayton, Ohio)

Nishiyama M,Nita A,Yumimoto K,Nakayama KI

Sun Nov 01 00:00:00 UTC 2015

FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development.

Stem cells (Dayton, Ohio)

Nishiyama M,Nita A,Yumimoto K,Nakayama KI

Sun Nov 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: connexin 31; Connexin-31; Cx31; Gap junction beta-3 protein; gap junction membrane channel protein beta 3; gap junction protein, beta 3, 31kDa

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Gene Aliases: Cnx31; CX31; Cxn-31; D4Wsu144e; DFNA2; DFNA2B; EKV; Gjb-3; GJB3

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UniProt ID: (Human) O75712, (Mouse) P28231, (Rat) P25305

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Entrez Gene ID: (Human) 2707, (Mouse) 14620, (Rat) 29585

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Function(s)

gap junction channel activity protein binding molecular_function

Process(es)

placenta development cell communication sensory perception of sound in utero embryonic development skin development transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GJB3 Polyclonal Antibody

GJB3 Antibody (12880-1-AP) in ICC/IF

Product Details

12880-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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